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Peptide record

TPDB10369

Antibacterial Antifungal Antiparasitic Antiviral Toxicity standard

24 amino acids

3D PDB MODEL

Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.

TPDB ID TPDB10369

Activity

Antibacterial Antifungal Antiparasitic Antiviral Toxicity

Activity_category_statistics

Anti-infective peptides Toxicity and safety peptides

Database_Source

AntiBP3 Peptipedia AFP-GFuse Antifungipept CAFPdb dbAMP dbAMP 3.0 i2APP

Sequence_Type

standard

Has_Modification No

Description A 24-aa standard natural multi-activity (Antibacterial, Antifungal, Antiparasitic, and other sources) peptide sequence curated from AntiBP3, Peptipedia, AFP-GFuse, and other sources, with an available 3D structural model.

Sequence

FLGMLLHGVGHAIHGLIHGKQNVE

FASTA

>TPDB10369|Antibacterial;Antifungal;Antiparasitic;Antiviral;Toxicity|length=24
FLGMLLHGVGHAIHGLIHGKQNVE

Formula C117H185N35O29S1

Absent Amino Acids RDCPSTWY

Common Amino Acids G

Mass 2578.03

PI 8.12

Basic Residues 5

Acidic Residues 1

Hydrophobic Residues 11

Net Charge +0

Boman Index 3.65

Hydrophobicity 0.413

Aliphatic Index 125.83

Half Life

Mammalian: 1.1 hour Yeast: 3 min E.coli: 2 min

Extinction Coefficient Cystines 0

Absorbance 280nm 0.00

Polar Residues 2

number

Amino Acid Distribution

A: 1 R: 0 N: 1 D: 0 C: 0 E: 1 Q: 1 G: 5 H: 4 I: 2 L: 4 K: 1 M: 1 F: 1 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 2

Length

Formula

C117H185N35O29S1

Mass

2578.03

8.12

Net Charge

Boman Index

3.65

Hydrophobicity

0.413

Evidence 1 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 45 µM

Target

Target Organism Escherichia coli

Source & Reference

Database Source dbAMP

Other

Source Activity Label	Source Definition
Antibacterial	dbAMP classified as Antibacterial under the Anti-bacterial function class.

Evidence Text

A 17-residue segment was used to test peptide activity. Active against Gram- E. coli (MIC 45 uM), E-tarda (MIC >90 uM), V. tapetis (MIC 22.5 uM), Gram+ S. iniae (MIC 45 uM), fungi C. alb

Evidence 2 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 22.5 µM

Target

Target Organism V. tapetis

Source & Reference

Database Source dbAMP

Other

Evidence Text

to test peptide activity. Active against Gram- E. coli (MIC 45 uM), E-tarda (MIC >90 uM), V. tapetis (MIC 22.5 uM), Gram+ S. iniae (MIC 45 uM), fungi C. albicans KCCM 11282 (MIC 22.5 uM), S. cerevisiae (M

Evidence 3 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 45 µM

Target

Target Organism S. iniae

Source & Reference

Database Source dbAMP

Other

Evidence Text

against Gram- E. coli (MIC 45 uM), E-tarda (MIC >90 uM), V. tapetis (MIC 22.5 uM), Gram+ S. iniae (MIC 45 uM), fungi C. albicans KCCM 11282 (MIC 22.5 uM), S. cerevisiae (MIC 11.25 uM), and parasite M

Evidence 4 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 22.5 µM

Target

Target Organism Candida albicans KCCM 11282

Source & Reference

Database Source dbAMP

Other

Evidence Text

45 uM), E-tarda (MIC >90 uM), V. tapetis (MIC 22.5 uM), Gram+ S. iniae (MIC 45 uM), fungi C. albicans KCCM 11282 (MIC 22.5 uM), S. cerevisiae (MIC 11.25 uM), and parasite M. avidus (MIC 0.4 uM).

Evidence 5 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 11.25 µM

Target

Target Organism S. cerevisiae

Source & Reference

Database Source dbAMP

Other

Evidence Text

is (MIC 22.5 uM), Gram+ S. iniae (MIC 45 uM), fungi C. albicans KCCM 11282 (MIC 22.5 uM), S. cerevisiae (MIC 11.25 uM), and parasite M. avidus (MIC 0.4 uM).

Evidence 6 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 0.4 µM

Target

Target Organism M. avidus

Source & Reference

Database Source dbAMP

Other

Evidence Text

), fungi C. albicans KCCM 11282 (MIC 22.5 uM), S. cerevisiae (MIC 11.25 uM), and parasite M. avidus (MIC 0.4 uM).

Evidence 7 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 45 µM

Target

Target Organism Escherichia coli

Source & Reference

Database Source dbAMP CAFPdb Antifungipept

Other

Source Activity Label	Source Definition
Antifungal	dbAMP classified under the Anti-fungal function class.

Evidence Text

A 17-residue segment was used to test peptide activity. Active against Gram- E. coli (MIC 45 uM), E-tarda (MIC >90 uM), V. tapetis (MIC 22.5 uM), Gram+ S. iniae (MIC 45 uM), fungi C. alb

Evidence 8 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 22.5 µM

Target

Target Organism V. tapetis

Source & Reference

Database Source dbAMP CAFPdb Antifungipept

Other

Evidence Text

Evidence 9 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 45 µM

Target

Target Organism S. iniae

Source & Reference

Database Source dbAMP CAFPdb Antifungipept

Other

Evidence Text

against Gram- E. coli (MIC 45 uM), E-tarda (MIC >90 uM), V. tapetis (MIC 22.5 uM), Gram+ S. iniae (MIC 45 uM), fungi C. albicans KCCM 11282 (MIC 22.5 uM), S. cerevisiae (MIC 11.25 uM), and parasite M

Evidence 10 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 22.5 µM

Target

Target Organism Candida albicans KCCM 11282

Source & Reference

Database Source dbAMP CAFPdb Antifungipept

Other

Evidence Text

45 uM), E-tarda (MIC >90 uM), V. tapetis (MIC 22.5 uM), Gram+ S. iniae (MIC 45 uM), fungi C. albicans KCCM 11282 (MIC 22.5 uM), S. cerevisiae (MIC 11.25 uM), and parasite M. avidus (MIC 0.4 uM).

Evidence 11 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 11.25 µM

Target

Target Organism S. cerevisiae

Source & Reference

Database Source dbAMP CAFPdb Antifungipept

Other

Evidence Text

is (MIC 22.5 uM), Gram+ S. iniae (MIC 45 uM), fungi C. albicans KCCM 11282 (MIC 22.5 uM), S. cerevisiae (MIC 11.25 uM), and parasite M. avidus (MIC 0.4 uM).

Evidence 12 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 0.4 µM

Target

Target Organism M. avidus

Source & Reference

Database Source dbAMP CAFPdb Antifungipept

Other

Evidence Text

), fungi C. albicans KCCM 11282 (MIC 22.5 uM), S. cerevisiae (MIC 11.25 uM), and parasite M. avidus (MIC 0.4 uM).

Evidence 13 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 45 µM

Target

Target Organism Escherichia coli

Source & Reference

Database Source dbAMP 3.0

Other

Source Activity Label	Source Definition
Antiparasitic	dbAMP 3.0 classified under the Anti-parasitic function class.

Evidence Text

A 17-residue segment was used to test peptide activity. Active against Gram- E. coli (MIC 45 uM), E-tarda (MIC >90 uM), V. tapetis (MIC 22.5 uM), Gram+ S. iniae (MIC 45 uM), fungi C. alb

Evidence 14 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 22.5 µM

Target

Target Organism V. tapetis

Source & Reference

Database Source dbAMP 3.0

Other

Evidence Text

Evidence 15 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 45 µM

Target

Target Organism S. iniae

Source & Reference

Database Source dbAMP 3.0

Other

Evidence Text

against Gram- E. coli (MIC 45 uM), E-tarda (MIC >90 uM), V. tapetis (MIC 22.5 uM), Gram+ S. iniae (MIC 45 uM), fungi C. albicans KCCM 11282 (MIC 22.5 uM), S. cerevisiae (MIC 11.25 uM), and parasite M

Evidence 16 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 22.5 µM

Target

Target Organism Candida albicans KCCM 11282

Source & Reference

Database Source dbAMP 3.0

Other

Evidence Text

45 uM), E-tarda (MIC >90 uM), V. tapetis (MIC 22.5 uM), Gram+ S. iniae (MIC 45 uM), fungi C. albicans KCCM 11282 (MIC 22.5 uM), S. cerevisiae (MIC 11.25 uM), and parasite M. avidus (MIC 0.4 uM).

Evidence 17 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 11.25 µM

Target

Target Organism S. cerevisiae

Source & Reference

Database Source dbAMP 3.0

Other

Evidence Text

is (MIC 22.5 uM), Gram+ S. iniae (MIC 45 uM), fungi C. albicans KCCM 11282 (MIC 22.5 uM), S. cerevisiae (MIC 11.25 uM), and parasite M. avidus (MIC 0.4 uM).

Evidence 18 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 0.4 µM

Target

Target Organism M. avidus

Source & Reference

Database Source dbAMP 3.0

Other

Evidence Text

), fungi C. albicans KCCM 11282 (MIC 22.5 uM), S. cerevisiae (MIC 11.25 uM), and parasite M. avidus (MIC 0.4 uM).

Evidence 19 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiviral

Activity Measurement 45 µM

Target

Target Organism Escherichia coli

Source & Reference

Database Source dbAMP 3.0

Other

Source Activity Label	Source Definition
Antiviral	dbAMP 3.0 classified under the Anti-viral function class.

Evidence Text

A 17-residue segment was used to test peptide activity. Active against Gram- E. coli (MIC 45 uM), E-tarda (MIC >90 uM), V. tapetis (MIC 22.5 uM), Gram+ S. iniae (MIC 45 uM), fungi C. alb

Evidence 20 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiviral

Activity Measurement 22.5 µM

Target

Target Organism V. tapetis

Source & Reference

Database Source dbAMP 3.0

Other

Evidence Text

Evidence 21 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiviral

Activity Measurement 45 µM

Target

Target Organism S. iniae

Source & Reference

Database Source dbAMP 3.0

Other

Evidence Text

against Gram- E. coli (MIC 45 uM), E-tarda (MIC >90 uM), V. tapetis (MIC 22.5 uM), Gram+ S. iniae (MIC 45 uM), fungi C. albicans KCCM 11282 (MIC 22.5 uM), S. cerevisiae (MIC 11.25 uM), and parasite M

Evidence 22 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiviral

Activity Measurement 22.5 µM

Target

Target Organism Candida albicans KCCM 11282

Source & Reference

Database Source dbAMP 3.0

Other

Evidence Text

45 uM), E-tarda (MIC >90 uM), V. tapetis (MIC 22.5 uM), Gram+ S. iniae (MIC 45 uM), fungi C. albicans KCCM 11282 (MIC 22.5 uM), S. cerevisiae (MIC 11.25 uM), and parasite M. avidus (MIC 0.4 uM).

Evidence 23 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiviral

Activity Measurement 11.25 µM

Target

Target Organism S. cerevisiae

Source & Reference

Database Source dbAMP 3.0

Other

Evidence Text

is (MIC 22.5 uM), Gram+ S. iniae (MIC 45 uM), fungi C. albicans KCCM 11282 (MIC 22.5 uM), S. cerevisiae (MIC 11.25 uM), and parasite M. avidus (MIC 0.4 uM).

Evidence 24 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiviral

Activity Measurement 0.4 µM

Target

Target Organism M. avidus

Source & Reference

Database Source dbAMP 3.0

Other

Evidence Text

), fungi C. albicans KCCM 11282 (MIC 22.5 uM), S. cerevisiae (MIC 11.25 uM), and parasite M. avidus (MIC 0.4 uM).

Evidence 25 Activity

Activity

Activity Endpoint 3% Hemolysis

Detail Source Activity Toxicity

Activity Measurement 56.02-28.01 µM

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

3% Hemolysis | 56.02-28.01 | µM | target cell: Human erythrocytes

Target

Target Cell Human erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Molecular, genomic, and expressional delineation of a piscidin from rock bream (Oplegnathus fasciatus) with evidence for the potent antimicrobial activities of Of-Pis1 peptide. | Fish Shellfish Immunol | 2016

Evidence 26 Activity

Activity

Activity Endpoint 2% Hemolysis

Detail Source Activity Toxicity

Activity Measurement 14.01-0.11 µM

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

2% Hemolysis | 14.01-0.11 | µM | target cell: Human erythrocytes

Target

Target Cell Human erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Reference