Back to search

Peptide record

TPDB10367

Antibacterial Antifungal Toxicity standard
24 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB10367
Antibacterial Antifungal Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 Peptipedia AFP-GFuse Antifungipept CAFPdb dbAMP ToxinPred 3.0
standard
No
A 24-aa standard-residue multi-activity (Antibacterial, Antifungal, and Toxicity) peptide sequence curated from AntiBP3, Peptipedia, AFP-GFuse, and other sources, with an available 3D structural model.
Sequence
RNGCIVDPRCPYQQCRRPLYCRRR
Physicochemical Analysis

Sequence-only estimates for a linear peptide with free termini, not experimentally measured molecular properties. Mass and formula exclude cyclization and disulfide formation. The optical estimates assume paired cysteines, 280 nm, 1 g/L and a 1 cm path. The N-end rule estimate is not a measured plasma half-life.

C124H206N48O32S4
AEHKMFSTW
R
3009.54
10.26
7
1
5
+6
4.63
-1.283
44.58
Mammalian: 1 hour Yeast: 2 min E.coli: 2 min
3230
1.07
9
Residue Composition
number
0
A
7
R
1
N
1
D
4
C
0
E
2
Q
1
G
0
H
1
I
1
L
0
K
0
M
0
F
3
P
0
S
0
T
0
W
2
Y
1
V
Amino Acid Distribution
A: 0 R: 7 N: 1 D: 1 C: 4 E: 0 Q: 2 G: 1 H: 0 I: 1 L: 1 K: 0 M: 0 F: 0 P: 3 S: 0 T: 0 W: 0 Y: 2 V: 1
Chemical Descriptors
24 reviewed residue count
C124H206N48O32S4 sequence-only estimate (linear, free termini)
3009.54 sequence-only estimate (linear, free termini)
10.26 sequence-only estimate (linear, free termini)
+6 sequence-only estimate (linear, free termini)
4.63 sequence-only estimate (linear, free termini)
-1.283 sequence-only estimate (linear, free termini)
Evidence Records 2 records
Evidence 1 Activity

Activity

0.88% Hemolysis
Toxicity
25 µM
Hemolytic Cytotoxic
0.88% Hemolysis | 25 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Potent Chimeric Antimicrobial Derivatives of the Medicago truncatula NCR247 Symbiotic Peptide. | Front Microbiol | 2020
Evidence 2 Activity

Activity

1.75% Hemolysis
Toxicity
100 µM
Hemolytic Cytotoxic
1.75% Hemolysis | 100 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Potent Chimeric Antimicrobial Derivatives of the Medicago truncatula NCR247 Symbiotic Peptide. | Front Microbiol | 2020