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Peptide record

TPDB10358

Antibacterial Antifungal Toxicity standard
24 amino acids
Basic Information
3D PDB MODEL
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TPDB10358
Antibacterial Antifungal Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 Peptipedia Antifungipept CAFPdb dbAMP
standard
No
A 24-aa standard-residue multi-activity (Antibacterial, Antifungal, and Toxicity) peptide sequence curated from AntiBP3, Peptipedia, Antifungipept, and other sources, with an available 3D structural model.
Sequence
ACPIFTKIQGTYRGKAKRIGRRIC
Physicochemical Analysis

Sequence-only estimates for a linear peptide with free termini, not experimentally measured molecular properties. Mass and formula exclude cyclization and disulfide formation. The optical estimates assume paired cysteines, 280 nm, 1 g/L and a 1 cm path. The N-end rule estimate is not a measured plasma half-life.

C120H206N40O29S2
NDEHLMSWV
RI
2737.33
11.42
7
0
8
+7
2.31
-0.388
73.33
Mammalian: 4.4 hour Yeast: >20 hour E.coli: >10 hour
1615
0.59
6
Residue Composition
number
2
A
4
R
0
N
0
D
2
C
0
E
1
Q
3
G
0
H
4
I
0
L
3
K
0
M
1
F
1
P
0
S
2
T
0
W
1
Y
0
V
Amino Acid Distribution
A: 2 R: 4 N: 0 D: 0 C: 2 E: 0 Q: 1 G: 3 H: 0 I: 4 L: 0 K: 3 M: 0 F: 1 P: 1 S: 0 T: 2 W: 0 Y: 1 V: 0
Chemical Descriptors
24 reviewed residue count
C120H206N40O29S2 sequence-only estimate (linear, free termini)
2737.33 sequence-only estimate (linear, free termini)
11.42 sequence-only estimate (linear, free termini)
+7 sequence-only estimate (linear, free termini)
2.31 sequence-only estimate (linear, free termini)
-0.388 sequence-only estimate (linear, free termini)
Evidence Records 2 records
Evidence 1 Activity

Activity

Toxicity
Hemolytic
NA | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
A hybrid cationic peptide composed of human ?-defensin-1 and humanized ?-defensin sequences exhibits salt-resistant antimicrobial activity. | Antimicrob Agents Chemother | 2015
Evidence 2 Activity

Activity

Toxicity
Cytotoxic
NA | target cell: Human embryonic kidney HEK293 cells

Target

Human embryonic kidney HEK293 cells

Source & Reference

NA
DBAASP
A hybrid cationic peptide composed of human ?-defensin-1 and humanized ?-defensin sequences exhibits salt-resistant antimicrobial activity. | Antimicrob Agents Chemother | 2015