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Peptide record

TPDB10351

Antibacterial Anticancer Toxicity standard
24 amino acids
Basic Information
3D PDB MODEL
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TPDB10351
Antibacterial Anticancer Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 Peptipedia CancerPPD 2.0
standard
No
A 24-aa standard natural multi-activity (Antibacterial, Anticancer, and Toxicity) peptide sequence curated from AntiBP3, Peptipedia, and CancerPPD 2.0, with an available 3D structural model.
Sequence
IWLTALKFLGKNLGKLAKQQLAKL
Physicochemical Analysis
C129H219N33O29
RDCEHMPSYV
L
2696.36
11.12
5
0
13
+5
-1.03
0.288
142.50
Mammalian: 20 hour Yeast: 30 min E.coli: >10 hour
5500
203.98
4
Residue Composition
number
3
A
0
R
1
N
0
D
0
C
0
E
2
Q
2
G
0
H
1
I
7
L
5
K
0
M
1
F
0
P
0
S
1
T
1
W
0
Y
0
V
Amino Acid Distribution
A: 3 R: 0 N: 1 D: 0 C: 0 E: 0 Q: 2 G: 2 H: 0 I: 1 L: 7 K: 5 M: 0 F: 1 P: 0 S: 0 T: 1 W: 1 Y: 0 V: 0
Chemical Descriptors
24
C129H219N33O29
2696.36
11.12
+5
-1.03
0.288
Evidence Records 6 records
Evidence 1 Activity

Activity

46.83% Hemolysis
Toxicity
46.8 µM
Hemolytic Cytotoxic
46.83% Hemolysis | 46.8 | µM | target cell: Sheep erythrocytes

Target

Sheep erythrocytes

Source & Reference

NA
DBAASP
LyeTxI-b, a Synthetic Peptide Derived From Lycosa erythrognatha Spider Venom, Shows Potent Antibiotic Activity in Vitro and in Vivo. | Front Microbiol | 2018
Evidence 2 Activity

Activity

IC50
Toxicity
4.16 ± 1.94 µM
Cytotoxic
IC50 | 4.16 ± 1.94 | µM | target cell: Human PBMC

Target

Human PBMC

Source & Reference

NA
DBAASP
The synthetic peptide LyeTxI-b derived from Lycosa erythrognatha spider venom is cytotoxic to U-87 MG glioblastoma cells | Amino Acids | 2018
Evidence 3 Activity

Activity

IC50
Toxicity
>100 µM
Cytotoxic
IC50 | >100 | µM | target cell: Vero cells

Target

Vero cells

Source & Reference

NA
DBAASP
The synthetic peptide LyeTxI-b derived from Lycosa erythrognatha spider venom is cytotoxic to U-87 MG glioblastoma cells | Amino Acids | 2018
Evidence 4 Activity

Activity

IC50
Toxicity
>100 µM
Cytotoxic
IC50 | >100 | µM | target cell: Human fibroblasts GM-637

Target

Human fibroblasts GM-637

Source & Reference

NA
DBAASP
The synthetic peptide LyeTxI-b derived from Lycosa erythrognatha spider venom is cytotoxic to U-87 MG glioblastoma cells | Amino Acids | 2018
Evidence 5 Activity

Activity

30-35% Hemolysis
Toxicity
100 µM
Hemolytic Cytotoxic
30-35% Hemolysis | 100 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
The synthetic peptide LyeTxI-b derived from Lycosa erythrognatha spider venom is cytotoxic to U-87 MG glioblastoma cells | Amino Acids | 2018
Evidence 6 Activity

Activity

IC50
Toxicity
155
Hemolytic Cytotoxic
Hemolytic_activity: hRBC(human blood red cells): IC50=155±13.04 µM (testing time is 48 h) | Cytotoxicity: Vero(African green monkey kidney): IC50≥100 µM (testing time is 48 h) PBMC(Peripheral Blood Mononuclear Cells): IC50=4.16±1.94 µM (testing time is 48 h) GM00637: IC50 ≥ 100 µM

Target

erythrocytes

Source & Reference

NA
DRAMP
Amino Acids. 2019 Mar 51(3):433-449.