TPDB

3D PDB MODEL

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TPDB ID TPDB10348

Activity

Antibacterial Hemolysis Toxicity

Activity_category_statistics

Anti-infective peptides Toxicity and safety peptides

Database_Source

AntiBP3 Peptipedia PD_Hemolysis

Sequence_Type

standard

Has_Modification No

Description A 24-aa standard natural multi-activity (Antibacterial, Hemolysis, and Toxicity) peptide sequence curated from AntiBP3, Peptipedia, and PD_Hemolysis, with an available 3D structural model.

Sequence

GVFRRLRKVTRKVLKKIGKVLKWI

FASTA

>TPDB10348|Antibacterial;Hemolysis;Toxicity|length=24
GVFRRLRKVTRKVLKKIGKVLKWI

Formula C138H245N43O26

Absent Amino Acids ANDCEQHMPSY

Common Amino Acids K

Mass 2922.74

PI 12.89

Basic Residues 10

Acidic Residues 0

Hydrophobic Residues 11

Net Charge +10

Boman Index 4.34

Hydrophobicity -0.158

Aliphatic Index 129.58

Half Life

Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour

Extinction Coefficient Cystines 5500

Absorbance 280nm 188.18

Polar Residues 1

number

0

A

4

R

0

N

0

D

0

C

0

E

0

Q

2

G

0

H

2

I

3

L

6

K

0

M

1

F

0

P

0

S

1

T

1

W

0

Y

4

V

Amino Acid Distribution

A: 0 R: 4 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 2 H: 0 I: 2 L: 3 K: 6 M: 0 F: 1 P: 0 S: 0 T: 1 W: 1 Y: 0 V: 4

Length

24

Formula

C138H245N43O26

Mass

2922.74

PI

12.89

Net Charge

+10

Boman Index

4.34

Hydrophobicity

-0.158

Evidence 1 Activity

Activity

Activity Endpoint 30% Hemolysis

Detail Source Activity Toxicity

Activity Measurement 32 µM

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

30% Hemolysis | 32 | µM | target cell: Human erythrocytes

Target

Target Cell Human erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Antimicrobial properties and membrane-active mechanism of a potential ?-helical antimicrobial derived from cathelicidin PMAP-36. | PLoS One | 2014

Evidence 2 Activity

Activity

Activity Endpoint 40% Hemolysis

Detail Source Activity Toxicity

Activity Measurement 64 µM

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

40% Hemolysis | 64 | µM | target cell: Human erythrocytes

Target

Target Cell Human erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Antimicrobial properties and membrane-active mechanism of a potential ?-helical antimicrobial derived from cathelicidin PMAP-36. | PLoS One | 2014

Evidence 3 Activity

Activity

Activity Endpoint 50% Hemolysis

Detail Source Activity Toxicity

Activity Measurement 128 µM

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

50% Hemolysis | 128 | µM | target cell: Human erythrocytes

Target

Target Cell Human erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Antimicrobial properties and membrane-active mechanism of a potential ?-helical antimicrobial derived from cathelicidin PMAP-36. | PLoS One | 2014

Evidence 4 Hemolysis

Source & Reference

source PD_Hemolysis

Database Source PD_Hemolysis