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Peptide record

TPDB10347

Antibacterial Anticancer Antifungal Toxicity standard
24 amino acids
Basic Information
3D PDB MODEL
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TPDB10347
Antibacterial Anticancer Antifungal Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 Peptipedia CancerPPD 2.0 Antifungipept CAFPdb dbAMP
standard
No
A 24-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, Peptipedia, CancerPPD 2.0, and other sources, with an available 3D structural model.
Sequence
GRKKRRQRRRGALWKSLLKNVGKA
Physicochemical Analysis
C124H224N50O28
DCEHIMFPTY
R
2863.46
13.11
11
0
7
+11
7.17
-1.550
69.17
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
5500
192.08
3
Residue Composition
number
2
A
6
R
1
N
0
D
0
C
0
E
1
Q
3
G
0
H
0
I
3
L
5
K
0
M
0
F
0
P
1
S
0
T
1
W
0
Y
1
V
Amino Acid Distribution
A: 2 R: 6 N: 1 D: 0 C: 0 E: 0 Q: 1 G: 3 H: 0 I: 0 L: 3 K: 5 M: 0 F: 0 P: 0 S: 1 T: 0 W: 1 Y: 0 V: 1
Chemical Descriptors
24
C124H224N50O28
2863.46
13.11
+11
7.17
-1.550
Evidence Records 3 records
Evidence 1 Activity

Activity

50% Hemolysis
Toxicity
>512 µM
Hemolytic Cytotoxic
50% Hemolysis | >512 | µM | target cell: Horse erythrocytes

Target

Horse erythrocytes

Source & Reference

NA
DBAASP
Discovery of two skin-derived dermaseptins and design of a TAT-fusion analogue with broad-spectrum antimicrobial activity and low cytotoxicity on healthy cells. | PeerJ | 2018
Evidence 2 Activity

Activity

IC50
Toxicity
>100 µM
Cytotoxic
IC50 | >100 | µM | target cell: Human microvascular endothelial cells HMEC-1

Target

Human microvascular endothelial cells HMEC-1

Source & Reference

NA
DBAASP
Discovery of two skin-derived dermaseptins and design of a TAT-fusion analogue with broad-spectrum antimicrobial activity and low cytotoxicity on healthy cells. | PeerJ | 2018
Evidence 3 Activity

Activity

Toxicity
Hemolytic Cytotoxic
Hemolytic_activity: Not available | Cytotoxicity: Not available

Target

erythrocytes

Source & Reference

NA
DRAMP
PeerJ. 2018 Sep 19 6:e5635.