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Peptide record

TPDB10330

Antibacterial Antifungal Hemolysis Toxicity standard
24 amino acids
Basic Information
3D PDB MODEL
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TPDB10330
Antibacterial Antifungal Hemolysis Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 Peptipedia AFP-GFuse Antifungipept CAFPdb dbAMP PD_Hemolysis ToxinPred 3.0
standard
No
A 24-aa standard natural multi-activity (Antibacterial, Antifungal, Hemolysis, and other sources) peptide sequence curated from AntiBP3, Peptipedia, AFP-GFuse, and other sources, with an available 3D structural model.
Sequence
FLGAVLKVAGKLVPAAICKISKKC
Physicochemical Analysis
C114H201N29O26S2
RNDEQHMTWY
K
2458.15
10.39
5
0
13
+5
1.17
1.054
134.17
Mammalian: 1.1 hour Yeast: 3 min E.coli: 2 min
125
5.09
3
Residue Composition
number
4
A
0
R
0
N
0
D
2
C
0
E
0
Q
2
G
0
H
2
I
3
L
5
K
0
M
1
F
1
P
1
S
0
T
0
W
0
Y
3
V
Amino Acid Distribution
A: 4 R: 0 N: 0 D: 0 C: 2 E: 0 Q: 0 G: 2 H: 0 I: 2 L: 3 K: 5 M: 0 F: 1 P: 1 S: 1 T: 0 W: 0 Y: 0 V: 3
Chemical Descriptors
24
C114H201N29O26S2
2458.15
10.39
+5
1.17
1.054
Evidence Records 14 records
Evidence 1 Activity

Activity

MIC
Antibacterial
2-4 µM

Target

Staphylococcus aureus or MRSA

Source & Reference

dbAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class.
Active against (G, F) Gram+ S. aureus or MRSA (MIC 2-4 uM), E. faecalis (MIC 8 uM) Gram- E. coli (MIC 4 uM), K. pneumoniae (MIC 8 uM), P. aeruginos
Evidence 2 Activity

Activity

MIC
Antibacterial
8 µM

Target

Enterococcus faecalis

Source & Reference

dbAMP

Other

Active against (G, F) Gram+ S. aureus or MRSA (MIC 2-4 uM), E. faecalis (MIC 8 uM) Gram- E. coli (MIC 4 uM), K. pneumoniae (MIC 8 uM), P. aeruginosa (MIC 32 uM), C. albica
Evidence 3 Activity

Activity

MIC
Antibacterial
4 µM

Target

Escherichia coli

Source & Reference

dbAMP

Other

Active against (G, F) Gram+ S. aureus or MRSA (MIC 2-4 uM), E. faecalis (MIC 8 uM) Gram- E. coli (MIC 4 uM), K. pneumoniae (MIC 8 uM), P. aeruginosa (MIC 32 uM), C. albicans (MIC 2 uM). Replaced 5/
Evidence 4 Activity

Activity

MIC
Antibacterial
8 µM

Target

Klebsiella pneumoniae

Source & Reference

dbAMP

Other

) Gram+ S. aureus or MRSA (MIC 2-4 uM), E. faecalis (MIC 8 uM) Gram- E. coli (MIC 4 uM), K. pneumoniae (MIC 8 uM), P. aeruginosa (MIC 32 uM), C. albicans (MIC 2 uM). Replaced 5/2020 with a more active pe
Evidence 5 Activity

Activity

MIC
Antibacterial
32 µM

Target

Pseudomonas aeruginosa

Source & Reference

dbAMP

Other

(MIC 2-4 uM), E. faecalis (MIC 8 uM) Gram- E. coli (MIC 4 uM), K. pneumoniae (MIC 8 uM), P. aeruginosa (MIC 32 uM), C. albicans (MIC 2 uM). Replaced 5/2020 with a more active peptide formatted 4/2024
Evidence 6 Activity

Activity

MIC
Antibacterial
2 µM

Target

Candida albicans

Source & Reference

dbAMP

Other

MIC 8 uM) Gram- E. coli (MIC 4 uM), K. pneumoniae (MIC 8 uM), P. aeruginosa (MIC 32 uM), C. albicans (MIC 2 uM). Replaced 5/2020 with a more active peptide formatted 4/2024
Evidence 7 Activity

Activity

MIC
Antifungal
2-4 µM

Target

Staphylococcus aureus or MRSA

Source & Reference

dbAMP CAFPdb Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class.
Active against (G, F) Gram+ S. aureus or MRSA (MIC 2-4 uM), E. faecalis (MIC 8 uM) Gram- E. coli (MIC 4 uM), K. pneumoniae (MIC 8 uM), P. aeruginos
Evidence 8 Activity

Activity

MIC
Antifungal
8 µM

Target

Enterococcus faecalis

Source & Reference

dbAMP CAFPdb Antifungipept

Other

Active against (G, F) Gram+ S. aureus or MRSA (MIC 2-4 uM), E. faecalis (MIC 8 uM) Gram- E. coli (MIC 4 uM), K. pneumoniae (MIC 8 uM), P. aeruginosa (MIC 32 uM), C. albica
Evidence 9 Activity

Activity

MIC
Antifungal
4 µM

Target

Escherichia coli

Source & Reference

dbAMP CAFPdb Antifungipept

Other

Active against (G, F) Gram+ S. aureus or MRSA (MIC 2-4 uM), E. faecalis (MIC 8 uM) Gram- E. coli (MIC 4 uM), K. pneumoniae (MIC 8 uM), P. aeruginosa (MIC 32 uM), C. albicans (MIC 2 uM). Replaced 5/
Evidence 10 Activity

Activity

MIC
Antifungal
8 µM

Target

Klebsiella pneumoniae

Source & Reference

dbAMP CAFPdb Antifungipept

Other

) Gram+ S. aureus or MRSA (MIC 2-4 uM), E. faecalis (MIC 8 uM) Gram- E. coli (MIC 4 uM), K. pneumoniae (MIC 8 uM), P. aeruginosa (MIC 32 uM), C. albicans (MIC 2 uM). Replaced 5/2020 with a more active pe
Evidence 11 Activity

Activity

MIC
Antifungal
32 µM

Target

Pseudomonas aeruginosa

Source & Reference

dbAMP CAFPdb Antifungipept

Other

(MIC 2-4 uM), E. faecalis (MIC 8 uM) Gram- E. coli (MIC 4 uM), K. pneumoniae (MIC 8 uM), P. aeruginosa (MIC 32 uM), C. albicans (MIC 2 uM). Replaced 5/2020 with a more active peptide formatted 4/2024
Evidence 12 Activity

Activity

MIC
Antifungal
2 µM

Target

Candida albicans

Source & Reference

dbAMP CAFPdb Antifungipept

Other

MIC 8 uM) Gram- E. coli (MIC 4 uM), K. pneumoniae (MIC 8 uM), P. aeruginosa (MIC 32 uM), C. albicans (MIC 2 uM). Replaced 5/2020 with a more active peptide formatted 4/2024
Evidence 13 Activity

Activity

20% Hemolysis
Toxicity
16 µM
Hemolytic Cytotoxic
20% Hemolysis | 16 | µM | target cell: Horse erythrocytes

Target

Horse erythrocytes

Source & Reference

NA
DBAASP
Evaluating the Bioactivity of a Novel Broad-Spectrum Antimicrobial Peptide Brevinin-1GHa from the Frog Skin Secretion of Hylarana guentheri and Its Analogues. | Toxins (Basel) | 2018
Evidence 14 Hemolysis

Source & Reference

PD_Hemolysis
PD_Hemolysis