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Peptide record

TPDB10329

Antibacterial Antifungal standard
24 amino acids
Basic Information
3D PDB MODEL
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TPDB10329
Antibacterial Antifungal
Anti-infective peptides
AntiBP3 Peptipedia Antifungipept
standard
No
A 24-aa standard natural multi-activity (Antibacterial and Antifungal) peptide sequence curated from AntiBP3, Peptipedia, and Antifungipept, with an available 3D structural model.
Sequence
LKRVWKRVFKLLKRYWRQLKKPVR
Physicochemical Analysis
C155H258N48O27
ANDCEGHIMST
K
3226.06
12.60
11
0
11
+11
3.22
-0.979
101.25
Mammalian: 5.5 hour Yeast: 3 min E.coli: 2 min
12490
387.16
2
Residue Composition
number
0
A
5
R
0
N
0
D
0
C
0
E
1
Q
0
G
0
H
0
I
4
L
6
K
0
M
1
F
1
P
0
S
0
T
2
W
1
Y
3
V
Amino Acid Distribution
A: 0 R: 5 N: 0 D: 0 C: 0 E: 0 Q: 1 G: 0 H: 0 I: 0 L: 4 K: 6 M: 0 F: 1 P: 1 S: 0 T: 0 W: 2 Y: 1 V: 3
Chemical Descriptors
24
C155H258N48O27
3226.06
12.60
+11
3.22
-0.979
Evidence Records 2 records
Evidence 1 Activity

Activity

Antibacterial

Source & Reference

NA

Other

SAAP-148 shows broad activity against the ESKAPE pathogens in 50% plasma, including E. faecium LUH15122 (LC99.9 6.4 uM), S. aureus LUH14616 (3.2-12.8), K. pneumoniae LUH15104 (12.8-25.6 uM), A. baumannii RUH875 (1.6-3.2 uM), P. aeruginosa LUH15103 (12.8-25.6 uM), E. cloacae LUH15114 (3.2-12.8 uM), and E. coli LUH15117 (6.4 uM). Fast killing.
Evidence 2 Activity

Activity

Antifungal

Source & Reference

Antifungipept

Other

SAAP-148 shows broad activity against the ESKAPE pathogens in 50% plasma, including E. faecium LUH15122 (LC99.9 6.4 uM), S. aureus LUH14616 (3.2-12.8), K. pneumoniae LUH15104 (12.8-25.6 uM), A. baumannii RUH875 (1.6-3.2 uM), P. aeruginosa LUH15103 (12.8-25.6 uM), E. cloacae LUH15114 (3.2-12.8 uM), and E. coli LUH15117 (6.4 uM). Fast killing.