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Peptide record

TPDB10317

Antibacterial Anticancer Hemolysis Toxicity standard
24 amino acids
Basic Information
3D PDB MODEL
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TPDB10317
Antibacterial Anticancer Hemolysis Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia PD_Hemolysis
standard
No
A 24-aa standard natural multi-activity (Antibacterial, Anticancer, Hemolysis, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
TRSRWRRFIRGAGRFARRYGWRIA
Physicochemical Analysis
C137H215N53O28
NDCEQHLKMPV
R
3052.55
12.94
9
0
10
+9
-0.44
-1.096
45.00
Mammalian: 7.2 hour Yeast: >20 hour E.coli: >10 hour
12490
409.17
3
Residue Composition
number
3
A
9
R
0
N
0
D
0
C
0
E
0
Q
3
G
0
H
2
I
0
L
0
K
0
M
2
F
0
P
1
S
1
T
2
W
1
Y
0
V
Amino Acid Distribution
A: 3 R: 9 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 3 H: 0 I: 2 L: 0 K: 0 M: 0 F: 2 P: 0 S: 1 T: 1 W: 2 Y: 1 V: 0
Chemical Descriptors
24
C137H215N53O28
3052.55
12.94
+9
-0.44
-1.096
Evidence Records 17 records
Evidence 1 Activity

Activity

MIC
Antibacterial
3-4.7 µg/mL

Target

Escherichia coli ATCC 25922 or clinical isolate

Source & Reference

dbAMP DRAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class. DRAMP antibacterial activity supported by MIC records against bacterial target organisms.
Active against Gram- E. coli ATCC 25922 or clinical isolate (MIC 3-4.7 ug/ml), P. aeruginosa ATCC 27853 (MIC 8 ug/ml), S. typhimurium ATCC 14028 (MIC 2 ug/ml), K. pneu
Evidence 2 Activity

Activity

MIC
Antibacterial
8 µg/mL

Target

Pseudomonas aeruginosa ATCC 27853

Source & Reference

dbAMP DRAMP

Other

Active against Gram- E. coli ATCC 25922 or clinical isolate (MIC 3-4.7 ug/ml), P. aeruginosa ATCC 27853 (MIC 8 ug/ml), S. typhimurium ATCC 14028 (MIC 2 ug/ml), K. pneumoniae (MIC 1.18 ug/ml), Gram+ S.aureus
Evidence 3 Activity

Activity

MIC
Antibacterial
2 µg/mL

Target

S. typhimurium ATCC 14028

Source & Reference

dbAMP DRAMP

Other

ATCC 25922 or clinical isolate (MIC 3-4.7 ug/ml), P. aeruginosa ATCC 27853 (MIC 8 ug/ml), S. typhimurium ATCC 14028 (MIC 2 ug/ml), K. pneumoniae (MIC 1.18 ug/ml), Gram+ S.aureus ATCC 29213 (MIC >128 ug/ml), B. cereus AT
Evidence 4 Activity

Activity

MIC
Antibacterial
1.18 µg/mL

Target

Klebsiella pneumoniae

Source & Reference

dbAMP DRAMP

Other

ug/ml), P. aeruginosa ATCC 27853 (MIC 8 ug/ml), S. typhimurium ATCC 14028 (MIC 2 ug/ml), K. pneumoniae (MIC 1.18 ug/ml), Gram+ S.aureus ATCC 29213 (MIC >128 ug/ml), B. cereus ATCC 10876 (MIC 32 ug/ml).
Evidence 5 Activity

Activity

MIC
Antibacterial
>128 µg/mL

Target

S.aureus ATCC 29213

Source & Reference

dbAMP DRAMP

Other

8 ug/ml), S. typhimurium ATCC 14028 (MIC 2 ug/ml), K. pneumoniae (MIC 1.18 ug/ml), Gram+ S.aureus ATCC 29213 (MIC >128 ug/ml), B. cereus ATCC 10876 (MIC 32 ug/ml).
Evidence 6 Activity

Activity

MIC
Antibacterial
32 µg/mL

Target

B. cereus ATCC 10876

Source & Reference

dbAMP DRAMP

Other

MIC 2 ug/ml), K. pneumoniae (MIC 1.18 ug/ml), Gram+ S.aureus ATCC 29213 (MIC >128 ug/ml), B. cereus ATCC 10876 (MIC 32 ug/ml).
Evidence 7 Activity

Activity

% Hemolysis
Hemolysis
0 0.3 0.4 0.4 0.2 %
[Ref.28630199]Hemolysis 0% at 4µg/ml against human red blood cell Hemolysis 1.2 ± 0.3% at 8µg/ml against human red blood cell Hemolysis 3.2 ± 0.4% at 16µg/ml against human red blood cell Hemolysis 6.5 ± 0.4% at 32µg/ml against human red blood cell Hemolysis 10.7 ± 0.2% at 64µg/ml against human red blood cell

Source & Reference

Hemolytik PD_Hemolysis
DRAMP4
Antimicrob Agents Chemother. 2017 Aug 24 61(9). pii: e00530-17.

Other

Source Activity Label Source Definition
Hemolysis
Hemolytik experimentally validated hemolytic peptide annotation.
Evidence 8 Activity

Activity

0% Hemolysis
Toxicity
4 µg/mL
Hemolytic Cytotoxic
0% Hemolysis | 4 | µg/mL | target cell: Chicken erythrocytes

Target

Chicken erythrocytes

Source & Reference

NA
DBAASP
Genomewide Analysis of the Antimicrobial Peptides in Python bivittatus and Characterization of Cathelicidins with Potent Antimicrobial Activity and Low Cytotoxicity. | Antimicrob Agents Chemother | 2017
Evidence 9 Activity

Activity

1.2±0.3% Hemolysis
Toxicity
8 µg/mL
Hemolytic Cytotoxic
1.2±0.3% Hemolysis | 8 | µg/mL | target cell: Chicken erythrocytes

Target

Chicken erythrocytes

Source & Reference

NA
DBAASP
Genomewide Analysis of the Antimicrobial Peptides in Python bivittatus and Characterization of Cathelicidins with Potent Antimicrobial Activity and Low Cytotoxicity. | Antimicrob Agents Chemother | 2017
Evidence 10 Activity

Activity

3.2±0.4% Hemolysis
Toxicity
16 µg/mL
Hemolytic Cytotoxic
3.2±0.4% Hemolysis | 16 | µg/mL | target cell: Chicken erythrocytes

Target

Chicken erythrocytes

Source & Reference

NA
DBAASP
Genomewide Analysis of the Antimicrobial Peptides in Python bivittatus and Characterization of Cathelicidins with Potent Antimicrobial Activity and Low Cytotoxicity. | Antimicrob Agents Chemother | 2017
Evidence 11 Activity

Activity

6.5±0.4% Hemolysis
Toxicity
32 µg/mL
Hemolytic Cytotoxic
6.5±0.4% Hemolysis | 32 | µg/mL | target cell: Chicken erythrocytes

Target

Chicken erythrocytes

Source & Reference

NA
DBAASP
Genomewide Analysis of the Antimicrobial Peptides in Python bivittatus and Characterization of Cathelicidins with Potent Antimicrobial Activity and Low Cytotoxicity. | Antimicrob Agents Chemother | 2017
Evidence 12 Activity

Activity

10.7±0.2% Hemolysis
Toxicity
64 µg/mL
Hemolytic Cytotoxic
10.7±0.2% Hemolysis | 64 | µg/mL | target cell: Chicken erythrocytes

Target

Chicken erythrocytes

Source & Reference

NA
DBAASP
Genomewide Analysis of the Antimicrobial Peptides in Python bivittatus and Characterization of Cathelicidins with Potent Antimicrobial Activity and Low Cytotoxicity. | Antimicrob Agents Chemother | 2017
Evidence 13 Activity

Activity

50% Cell death
Toxicity
>30 µg/mL
Cytotoxic
50% Cell death | >30 | µg/mL | target cell: Pig kidney epithelial cells PK15

Target

Pig kidney epithelial cells PK15

Source & Reference

NA
DBAASP
Genomewide Analysis of the Antimicrobial Peptides in Python bivittatus and Characterization of Cathelicidins with Potent Antimicrobial Activity and Low Cytotoxicity. | Antimicrob Agents Chemother | 2017
Evidence 14 Activity

Activity

50% Cell death
Toxicity
>30 µg/mL
Cytotoxic
50% Cell death | >30 | µg/mL | target cell: Human embryonic kidney HEK293T cells

Target

Human embryonic kidney HEK293T cells

Source & Reference

NA
DBAASP
Genomewide Analysis of the Antimicrobial Peptides in Python bivittatus and Characterization of Cathelicidins with Potent Antimicrobial Activity and Low Cytotoxicity. | Antimicrob Agents Chemother | 2017
Evidence 15 Activity

Activity

50% Cell death
Toxicity
>30 µg/mL
Cytotoxic
50% Cell death | >30 | µg/mL | target cell: Human keratinocytes HaCat

Target

Human keratinocytes HaCat

Source & Reference

NA
DBAASP
Genomewide Analysis of the Antimicrobial Peptides in Python bivittatus and Characterization of Cathelicidins with Potent Antimicrobial Activity and Low Cytotoxicity. | Antimicrob Agents Chemother | 2017
Evidence 16 Activity

Activity

Toxicity
Hemolytic
Hemolytic_activity: [Ref.28630199]Hemolysis 0% at 4µg/ml against human red blood cell Hemolysis 1.2 ± 0.3% at 8µg/ml against human red blood cell Hemolysis 3.2 ± 0.4% at 16µg/ml against human red blood cell Hemolysis 6.5 ± 0.4% at 32µg/ml against human red blood cell Hemolysis 10.7 ± 0.2% at 64µg/ml against human red blood cell

Target

erythrocytes

Source & Reference

NA
DRAMP
Antimicrob Agents Chemother. 2017 Aug 24 61(9). pii: e00530-17.
Evidence 17 Hemolysis

Activity

0 0.3 0.4 0.4 0.2 %
% Hemolysis
[Ref.28630199]Hemolysis 0% at 4µg/ml against human red blood cell Hemolysis 1.2 ± 0.3% at 8µg/ml against human red blood cell Hemolysis 3.2 ± 0.4% at 16µg/ml against human red blood cell Hemolysis 6.5 ± 0.4% at 32µg/ml against human red blood cell Hemolysis 10.7 ± 0.2% at 64µg/ml against human red blood cell
Hemolysis

Source & Reference

PD_Hemolysis
Antimicrob Agents Chemother. 2017 Aug 24 61(9). pii: e00530-17.
DRAMP4
PD_Hemolysis