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Peptide record

TPDB10293

Brevinin-1RL1 Antibacterial Anticancer Antifungal standard
24 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB10293
Brevinin-1RL1
Antibacterial Anticancer Antifungal
Anti-infective peptides Cancer-related peptides
AntiBP3 Peptipedia CancerPPD 2.0 dbACP AFP-GFuse Antifungipept CAFPdb dbAMP
standard
No
A 24-aa standard natural multi-activity (Antibacterial, Anticancer, and Antifungal) peptide sequence curated from AntiBP3, Peptipedia, CancerPPD 2.0, and other sources, with an available 3D structural model.
Sequence
FFPLIAGLAARFLPKIFCSITKRC
Physicochemical Analysis
C130H206N32O27S2
NDEQHMWYV
F
2713.38
10.58
4
0
13
+4
-3.34
1.025
110.00
Mammalian: 1.1 hour Yeast: 3 min E.coli: 2 min
125
4.61
4
Residue Composition
number
3
A
2
R
0
N
0
D
2
C
0
E
0
Q
1
G
0
H
3
I
3
L
2
K
0
M
4
F
2
P
1
S
1
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 3 R: 2 N: 0 D: 0 C: 2 E: 0 Q: 0 G: 1 H: 0 I: 3 L: 3 K: 2 M: 0 F: 4 P: 2 S: 1 T: 1 W: 0 Y: 0 V: 0
Chemical Descriptors
24
C130H206N32O27S2
2713.38
10.58
+4
-3.34
1.025
Free
L
Cyclic(C18-C24)
Free
Antimicrobial
Rana limnocharis
Evidence Records 20 records
Evidence 1 Activity

Activity

MIC
Antibacterial
5 µg/mL

Target

Enterococcus faecalis ATCC29212

Source & Reference

dbAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class.
Active against S. aureus ATCC25923 or IS10# or IS37# (MIC 5-10 ug/ml), E. faecalis ATCC29212 (MIC 5 ug/ml), E. coli ATCC25922 or IS37# or IS117# (MIC 1-10 ug/ml), E. cloacae ATCC13047 (MIC 2.5 and
Evidence 2 Activity

Activity

MIC
Antibacterial
2.5 µg/mL

Target

Klebsiella pneumoniae ATCC700603

Source & Reference

dbAMP

Other

coli ATCC25922 or IS37# or IS117# (MIC 1-10 ug/ml), E. cloacae ATCC13047 (MIC 2.5 and 5), K. pneumoniae ATCC700603 (MIC 2.5 ug/ml), B. dysenteriae (MIC 10 ug/ml), B. pyocyaneus CMCCB1010 (MIC 5 ug/ml), P. aeruginosa ATCC
Evidence 3 Activity

Activity

MIC
Antibacterial
10 µg/mL

Target

B. dysenteriae

Source & Reference

dbAMP

Other

0 ug/ml), E. cloacae ATCC13047 (MIC 2.5 and 5), K. pneumoniae ATCC700603 (MIC 2.5 ug/ml), B. dysenteriae (MIC 10 ug/ml), B. pyocyaneus CMCCB1010 (MIC 5 ug/ml), P. aeruginosa ATCC27853 (MIC 10 ug/ml), C. albica
Evidence 4 Activity

Activity

MIC
Antibacterial
5 µg/mL

Target

B. pyocyaneus CMCCB1010

Source & Reference

dbAMP

Other

(MIC 2.5 and 5), K. pneumoniae ATCC700603 (MIC 2.5 ug/ml), B. dysenteriae (MIC 10 ug/ml), B. pyocyaneus CMCCB1010 (MIC 5 ug/ml), P. aeruginosa ATCC27853 (MIC 10 ug/ml), C. albicans ATCC2002 or ATCC90028 (MIC 5-10 ug/m
Evidence 5 Activity

Activity

MIC
Antibacterial
10 µg/mL

Target

Pseudomonas aeruginosa ATCC27853

Source & Reference

dbAMP

Other

03 (MIC 2.5 ug/ml), B. dysenteriae (MIC 10 ug/ml), B. pyocyaneus CMCCB1010 (MIC 5 ug/ml), P. aeruginosa ATCC27853 (MIC 10 ug/ml), C. albicans ATCC2002 or ATCC90028 (MIC 5-10 ug/ml), C. parapsilosis ATCC22019 (MIC 20 ug
Evidence 6 Activity

Activity

MIC
Antibacterial
5-10 µg/mL

Target

Candida albicans ATCC2002 or ATCC90028

Source & Reference

dbAMP

Other

10 ug/ml), B. pyocyaneus CMCCB1010 (MIC 5 ug/ml), P. aeruginosa ATCC27853 (MIC 10 ug/ml), C. albicans ATCC2002 or ATCC90028 (MIC 5-10 ug/ml), C. parapsilosis ATCC22019 (MIC 20 ug/ml). UPdated 6/2023
Evidence 7 Activity

Activity

MIC
Antibacterial
20 µg/mL

Target

C. parapsilosis ATCC22019

Source & Reference

dbAMP

Other

aeruginosa ATCC27853 (MIC 10 ug/ml), C. albicans ATCC2002 or ATCC90028 (MIC 5-10 ug/ml), C. parapsilosis ATCC22019 (MIC 20 ug/ml). UPdated 6/2023
Evidence 8 Activity

Activity

IC50
IC50 = 5.87 ± 0.15 µM
Anticancer
5.87

Target

Colon Cancer
HCT-116
Colon

Assay & Model

MTS assay
48-h

Source & Reference

CancerPPD 2.0 dbACP
CancerPPD2
2021

Other

Source Activity Label Source Definition
Anticancer
CancerPPD 2.0 manually curated experimentally verified anticancer peptide/protein annotation.
Evidence 9 Activity

Activity

IC50
IC50 = 5.44 ± 0.33 µM
Anticancer
5.44

Target

Breast Cancer
MDA-MB-231
Breast

Assay & Model

MTS assay
48-h

Source & Reference

CancerPPD 2.0 dbACP
CancerPPD2
2021
Evidence 10 Activity

Activity

IC50
IC50 = 10.37 ± 0.40 µM
Anticancer
10.37

Target

Blood Cancer
SW-480
Blood

Assay & Model

MTS assay
48-h

Source & Reference

CancerPPD 2.0 dbACP
CancerPPD2
2021
Evidence 11 Activity

Activity

IC50
IC50 = 5.81 ± 0.23 µM
Anticancer
5.81

Target

Lung Cancer
A-549
Lung

Assay & Model

MTS assay
48-h

Source & Reference

CancerPPD 2.0 dbACP
CancerPPD2
2021
Evidence 12 Activity

Activity

IC50
IC50 = 6.87 ± 0.51 µM
Anticancer
6.87

Target

Liver Cancer
SMMC-7721
Liver

Assay & Model

MTS assay
48-h

Source & Reference

CancerPPD 2.0 dbACP
CancerPPD2
2021
Evidence 13 Activity

Activity

IC50
IC50 = 6.65 ± 0.33 µM
Anticancer
6.65

Target

Skin Cancer
B16-F10
Skin

Assay & Model

MTS assay
48-h

Source & Reference

CancerPPD 2.0 dbACP
CancerPPD2
2021
Evidence 14 Activity

Activity

MIC
Antifungal
5 µg/mL

Target

Enterococcus faecalis ATCC29212

Source & Reference

dbAMP CAFPdb Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class.
Active against S. aureus ATCC25923 or IS10# or IS37# (MIC 5-10 ug/ml), E. faecalis ATCC29212 (MIC 5 ug/ml), E. coli ATCC25922 or IS37# or IS117# (MIC 1-10 ug/ml), E. cloacae ATCC13047 (MIC 2.5 and
Evidence 15 Activity

Activity

MIC
Antifungal
2.5 µg/mL

Target

Klebsiella pneumoniae ATCC700603

Source & Reference

dbAMP CAFPdb Antifungipept

Other

coli ATCC25922 or IS37# or IS117# (MIC 1-10 ug/ml), E. cloacae ATCC13047 (MIC 2.5 and 5), K. pneumoniae ATCC700603 (MIC 2.5 ug/ml), B. dysenteriae (MIC 10 ug/ml), B. pyocyaneus CMCCB1010 (MIC 5 ug/ml), P. aeruginosa ATCC
Evidence 16 Activity

Activity

MIC
Antifungal
10 µg/mL

Target

B. dysenteriae

Source & Reference

dbAMP CAFPdb Antifungipept

Other

0 ug/ml), E. cloacae ATCC13047 (MIC 2.5 and 5), K. pneumoniae ATCC700603 (MIC 2.5 ug/ml), B. dysenteriae (MIC 10 ug/ml), B. pyocyaneus CMCCB1010 (MIC 5 ug/ml), P. aeruginosa ATCC27853 (MIC 10 ug/ml), C. albica
Evidence 17 Activity

Activity

MIC
Antifungal
5 µg/mL

Target

B. pyocyaneus CMCCB1010

Source & Reference

dbAMP CAFPdb Antifungipept

Other

(MIC 2.5 and 5), K. pneumoniae ATCC700603 (MIC 2.5 ug/ml), B. dysenteriae (MIC 10 ug/ml), B. pyocyaneus CMCCB1010 (MIC 5 ug/ml), P. aeruginosa ATCC27853 (MIC 10 ug/ml), C. albicans ATCC2002 or ATCC90028 (MIC 5-10 ug/m
Evidence 18 Activity

Activity

MIC
Antifungal
10 µg/mL

Target

Pseudomonas aeruginosa ATCC27853

Source & Reference

dbAMP CAFPdb Antifungipept

Other

03 (MIC 2.5 ug/ml), B. dysenteriae (MIC 10 ug/ml), B. pyocyaneus CMCCB1010 (MIC 5 ug/ml), P. aeruginosa ATCC27853 (MIC 10 ug/ml), C. albicans ATCC2002 or ATCC90028 (MIC 5-10 ug/ml), C. parapsilosis ATCC22019 (MIC 20 ug
Evidence 19 Activity

Activity

MIC
Antifungal
5-10 µg/mL

Target

Candida albicans ATCC2002 or ATCC90028

Source & Reference

dbAMP CAFPdb Antifungipept

Other

10 ug/ml), B. pyocyaneus CMCCB1010 (MIC 5 ug/ml), P. aeruginosa ATCC27853 (MIC 10 ug/ml), C. albicans ATCC2002 or ATCC90028 (MIC 5-10 ug/ml), C. parapsilosis ATCC22019 (MIC 20 ug/ml). UPdated 6/2023
Evidence 20 Activity

Activity

MIC
Antifungal
20 µg/mL

Target

C. parapsilosis ATCC22019

Source & Reference

dbAMP CAFPdb Antifungipept

Other

aeruginosa ATCC27853 (MIC 10 ug/ml), C. albicans ATCC2002 or ATCC90028 (MIC 5-10 ug/ml), C. parapsilosis ATCC22019 (MIC 20 ug/ml). UPdated 6/2023