TPDB

3D PDB MODEL

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TPDB ID TPDB10290

Activity

Antibacterial Antifungal Hemolysis Toxicity

Activity_category_statistics

Anti-infective peptides Toxicity and safety peptides

Database_Source

AntiBP3 dbAMP DRAMP Peptipedia Antifungipept CAFPdb PD_Hemolysis

Sequence_Type

standard

Has_Modification No

Description A 24-aa standard natural multi-activity (Antibacterial, Antifungal, Hemolysis, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.

Sequence

RIKRFWPVVIRTVVAGYNLYRAIK

FASTA

>TPDB10290|Antibacterial;Antifungal;Hemolysis;Toxicity|length=24
RIKRFWPVVIRTVVAGYNLYRAIK

Formula C139H224N40O29

Absent Amino Acids DCEQHMS

Common Amino Acids RV

Mass 2919.56

PI 11.98

Basic Residues 6

Acidic Residues 0

Hydrophobic Residues 14

Net Charge +6

Boman Index -0.17

Hydrophobicity 0.208

Aliphatic Index 121.67

Half Life

Mammalian: 1 hour Yeast: 2 min E.coli: 2 min

Extinction Coefficient Cystines 8480

Absorbance 280nm 290.45

Polar Residues 4

number

2

A

4

R

1

N

0

D

0

C

0

E

0

Q

1

G

0

H

3

I

1

L

2

K

0

M

1

F

1

P

0

S

1

T

1

W

2

Y

4

V

Amino Acid Distribution

A: 2 R: 4 N: 1 D: 0 C: 0 E: 0 Q: 0 G: 1 H: 0 I: 3 L: 1 K: 2 M: 0 F: 1 P: 1 S: 0 T: 1 W: 1 Y: 2 V: 4

Length

24

Formula

C139H224N40O29

Mass

2919.56

PI

11.98

Net Charge

+6

Boman Index

-0.17

Hydrophobicity

0.208

Evidence 1 Activity

Activity

Activity Endpoint 24% Hemolysis

Detail Source Activity Toxicity

Activity Measurement 200 µg/mL

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

24% Hemolysis | 200 | µg/mL | target cell: Human erythrocytes

Target

Target Cell Human erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Structure-function relationship of antimicrobial peptide cathelicidin Pc-CATH1 | Nat Prod Bioprospect | 2012

Evidence 2 Activity

Activity

Activity Endpoint 17% Hemolysis

Detail Source Activity Toxicity

Activity Measurement 100 µg/mL

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

17% Hemolysis | 100 | µg/mL | target cell: Human erythrocytes

Target

Target Cell Human erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Structure-function relationship of antimicrobial peptide cathelicidin Pc-CATH1 | Nat Prod Bioprospect | 2012

Evidence 3 Activity

Activity

Activity Endpoint 14% Hemolysis

Detail Source Activity Toxicity

Activity Measurement 50 µg/mL

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

14% Hemolysis | 50 | µg/mL | target cell: Human erythrocytes

Target

Target Cell Human erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Structure-function relationship of antimicrobial peptide cathelicidin Pc-CATH1 | Nat Prod Bioprospect | 2012

Evidence 4 Hemolysis

Source & Reference

source PD_Hemolysis

Database Source PD_Hemolysis