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Peptide record

TPDB10289

Antibacterial Antifungal Hemolysis Toxicity standard
24 amino acids
Basic Information
3D PDB MODEL
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TPDB10289
Antibacterial Antifungal Hemolysis Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 Peptipedia Antifungipept CAFPdb dbAMP APD_complete APD_hemolytic HemoPI Hemolytic2 PD_Hemolysis ToxinPred 3.0
standard
No
A 24-aa standard natural multi-activity (Antibacterial, Antifungal, Hemolysis, and other sources) peptide sequence curated from AntiBP3, Peptipedia, Antifungipept, and other sources, with an available 3D structural model.
Sequence
FLPIVASLAANFLPKIICKITKKC
Physicochemical Analysis
C125H211N29O28S2
RDEQGHMWY
IK
2632.35
10.17
4
0
13
+4
-0.55
1.075
138.33
Mammalian: 1.1 hour Yeast: 3 min E.coli: 2 min
125
4.75
5
Residue Composition
number
3
A
0
R
1
N
0
D
2
C
0
E
0
Q
0
G
0
H
4
I
3
L
4
K
0
M
2
F
2
P
1
S
1
T
0
W
0
Y
1
V
Amino Acid Distribution
A: 3 R: 0 N: 1 D: 0 C: 2 E: 0 Q: 0 G: 0 H: 0 I: 4 L: 3 K: 4 M: 0 F: 2 P: 2 S: 1 T: 1 W: 0 Y: 0 V: 1
Chemical Descriptors
24
C125H211N29O28S2
2632.35
10.17
+4
-0.55
1.075
Evidence Records 22 records
Evidence 1 Activity

Activity

MIC
Antibacterial
6.3 µM

Target

Staphylococcus aureus ATCC 25923

Source & Reference

dbAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class.
Active against Gram+ S. aureus ATCC 25923 (MIC 6.3 uM), E. faecium 091299 (MIC 25 uM), E. faecalis 981 (MIC 6.3 uM), N. asteroides 201118 (MIC 3
Evidence 2 Activity

Activity

MIC
Antibacterial
25 µM

Target

E. faecium 091299

Source & Reference

dbAMP

Other

Active against Gram+ S. aureus ATCC 25923 (MIC 6.3 uM), E. faecium 091299 (MIC 25 uM), E. faecalis 981 (MIC 6.3 uM), N. asteroides 201118 (MIC 3.1 uM), Gram- P.aeruginosa CGMC
Evidence 3 Activity

Activity

MIC
Antibacterial
6.3 µM

Target

Enterococcus faecalis 981

Source & Reference

dbAMP

Other

Active against Gram+ S. aureus ATCC 25923 (MIC 6.3 uM), E. faecium 091299 (MIC 25 uM), E. faecalis 981 (MIC 6.3 uM), N. asteroides 201118 (MIC 3.1 uM), Gram- P.aeruginosa CGMCC 1.50 (MIC >100 uM), K. pneum
Evidence 4 Activity

Activity

MIC
Antibacterial
3.1 µM

Target

N. asteroides 201118

Source & Reference

dbAMP

Other

eus ATCC 25923 (MIC 6.3 uM), E. faecium 091299 (MIC 25 uM), E. faecalis 981 (MIC 6.3 uM), N. asteroides 201118 (MIC 3.1 uM), Gram- P.aeruginosa CGMCC 1.50 (MIC >100 uM), K. pneumoniae 08040724 (MIC 100 uM), E. clo
Evidence 5 Activity

Activity

MIC
Antibacterial
100 µM

Target

Klebsiella pneumoniae 08040724

Source & Reference

dbAMP

Other

6.3 uM), N. asteroides 201118 (MIC 3.1 uM), Gram- P.aeruginosa CGMCC 1.50 (MIC >100 uM), K. pneumoniae 08040724 (MIC 100 uM), E. cloacae CGMCC 1.57 (MIC 25 uM), E. coli ATCC 25922 (MIC 100 uM), P. faecalis X29 (MIC
Evidence 6 Activity

Activity

MIC
Antibacterial
100 µM

Target

Escherichia coli ATCC 25922

Source & Reference

dbAMP

Other

50 (MIC >100 uM), K. pneumoniae 08040724 (MIC 100 uM), E. cloacae CGMCC 1.57 (MIC 25 uM), E. coli ATCC 25922 (MIC 100 uM), P. faecalis X29 (MIC 12.5 uM), and fungi C. glabrata 090902 (MIC 6.3 uM), and C. albican
Evidence 7 Activity

Activity

MIC
Antibacterial
12.5 µM

Target

P. faecalis X29

Source & Reference

dbAMP

Other

8040724 (MIC 100 uM), E. cloacae CGMCC 1.57 (MIC 25 uM), E. coli ATCC 25922 (MIC 100 uM), P. faecalis X29 (MIC 12.5 uM), and fungi C. glabrata 090902 (MIC 6.3 uM), and C. albicans(ATCC 10231 (MIC 100 uM).
Evidence 8 Activity

Activity

MIC
Antibacterial
6.3 µM

Target

C. glabrata 090902

Source & Reference

dbAMP

Other

57 (MIC 25 uM), E. coli ATCC 25922 (MIC 100 uM), P. faecalis X29 (MIC 12.5 uM), and fungi C. glabrata 090902 (MIC 6.3 uM), and C. albicans(ATCC 10231 (MIC 100 uM).
Evidence 9 Activity

Activity

MIC
Antifungal
6.3 µM

Target

Staphylococcus aureus ATCC 25923

Source & Reference

dbAMP CAFPdb Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class.
Active against Gram+ S. aureus ATCC 25923 (MIC 6.3 uM), E. faecium 091299 (MIC 25 uM), E. faecalis 981 (MIC 6.3 uM), N. asteroides 201118 (MIC 3
Evidence 10 Activity

Activity

MIC
Antifungal
25 µM

Target

E. faecium 091299

Source & Reference

dbAMP CAFPdb Antifungipept

Other

Active against Gram+ S. aureus ATCC 25923 (MIC 6.3 uM), E. faecium 091299 (MIC 25 uM), E. faecalis 981 (MIC 6.3 uM), N. asteroides 201118 (MIC 3.1 uM), Gram- P.aeruginosa CGMC
Evidence 11 Activity

Activity

MIC
Antifungal
6.3 µM

Target

Enterococcus faecalis 981

Source & Reference

dbAMP CAFPdb Antifungipept

Other

Active against Gram+ S. aureus ATCC 25923 (MIC 6.3 uM), E. faecium 091299 (MIC 25 uM), E. faecalis 981 (MIC 6.3 uM), N. asteroides 201118 (MIC 3.1 uM), Gram- P.aeruginosa CGMCC 1.50 (MIC >100 uM), K. pneum
Evidence 12 Activity

Activity

MIC
Antifungal
3.1 µM

Target

N. asteroides 201118

Source & Reference

dbAMP CAFPdb Antifungipept

Other

eus ATCC 25923 (MIC 6.3 uM), E. faecium 091299 (MIC 25 uM), E. faecalis 981 (MIC 6.3 uM), N. asteroides 201118 (MIC 3.1 uM), Gram- P.aeruginosa CGMCC 1.50 (MIC >100 uM), K. pneumoniae 08040724 (MIC 100 uM), E. clo
Evidence 13 Activity

Activity

MIC
Antifungal
100 µM

Target

Klebsiella pneumoniae 08040724

Source & Reference

dbAMP CAFPdb Antifungipept

Other

6.3 uM), N. asteroides 201118 (MIC 3.1 uM), Gram- P.aeruginosa CGMCC 1.50 (MIC >100 uM), K. pneumoniae 08040724 (MIC 100 uM), E. cloacae CGMCC 1.57 (MIC 25 uM), E. coli ATCC 25922 (MIC 100 uM), P. faecalis X29 (MIC
Evidence 14 Activity

Activity

MIC
Antifungal
100 µM

Target

Escherichia coli ATCC 25922

Source & Reference

dbAMP CAFPdb Antifungipept

Other

50 (MIC >100 uM), K. pneumoniae 08040724 (MIC 100 uM), E. cloacae CGMCC 1.57 (MIC 25 uM), E. coli ATCC 25922 (MIC 100 uM), P. faecalis X29 (MIC 12.5 uM), and fungi C. glabrata 090902 (MIC 6.3 uM), and C. albican
Evidence 15 Activity

Activity

MIC
Antifungal
12.5 µM

Target

P. faecalis X29

Source & Reference

dbAMP CAFPdb Antifungipept

Other

8040724 (MIC 100 uM), E. cloacae CGMCC 1.57 (MIC 25 uM), E. coli ATCC 25922 (MIC 100 uM), P. faecalis X29 (MIC 12.5 uM), and fungi C. glabrata 090902 (MIC 6.3 uM), and C. albicans(ATCC 10231 (MIC 100 uM).
Evidence 16 Activity

Activity

MIC
Antifungal
6.3 µM

Target

C. glabrata 090902

Source & Reference

dbAMP CAFPdb Antifungipept

Other

57 (MIC 25 uM), E. coli ATCC 25922 (MIC 100 uM), P. faecalis X29 (MIC 12.5 uM), and fungi C. glabrata 090902 (MIC 6.3 uM), and C. albicans(ATCC 10231 (MIC 100 uM).
Evidence 17 Activity

Activity

12% Hemolysis
Toxicity
6.3 µM
Hemolytic Cytotoxic
12% Hemolysis | 6.3 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Identification of multiple peptides with antioxidant and antimicrobial activities from skin and its secretions of Hylarana taipehensis, Amolops lifanensis, and Amolops granulosus. | Biochimie | 2014
Evidence 18 Activity

Activity

29% Hemolysis
Toxicity
12.5 µM
Hemolytic Cytotoxic
29% Hemolysis | 12.5 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Identification of multiple peptides with antioxidant and antimicrobial activities from skin and its secretions of Hylarana taipehensis, Amolops lifanensis, and Amolops granulosus. | Biochimie | 2014
Evidence 19 Activity

Activity

46% Hemolysis
Toxicity
25 µM
Hemolytic Cytotoxic
46% Hemolysis | 25 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Identification of multiple peptides with antioxidant and antimicrobial activities from skin and its secretions of Hylarana taipehensis, Amolops lifanensis, and Amolops granulosus. | Biochimie | 2014
Evidence 20 Activity

Activity

68% Hemolysis
Toxicity
50 µM
Hemolytic Cytotoxic
68% Hemolysis | 50 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Identification of multiple peptides with antioxidant and antimicrobial activities from skin and its secretions of Hylarana taipehensis, Amolops lifanensis, and Amolops granulosus. | Biochimie | 2014
Evidence 21 Activity

Activity

81% Hemolysis
Toxicity
100 µM
Hemolytic Cytotoxic
81% Hemolysis | 100 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Identification of multiple peptides with antioxidant and antimicrobial activities from skin and its secretions of Hylarana taipehensis, Amolops lifanensis, and Amolops granulosus. | Biochimie | 2014
Evidence 22 Hemolysis

Source & Reference

APD_complete APD_hemolytic HemoPI PD_Hemolysis
APD_complete APD_hemolytic PD_Hemolysis

Other

Source Activity Label Source Definition
Hemolysis
APD_complete APD-derived hemolytic peptide annotation. APD_hemolytic APD hemolytic peptide annotation.