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Peptide record

TPDB10285

Caerin 1.9 Antibacterial Anticancer Antifungal Antiparasitic Antiviral standard

24 amino acids

3D PDB MODEL

Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.

TPDB ID TPDB10285

Peptide_Name

Caerin 1.9

Activity

Antibacterial Anticancer Antifungal Antiparasitic Antiviral

Activity_category_statistics

Anti-infective peptides Cancer-related peptides

Database_Source

AntiBP3 Peptipedia AntiCP 2.0 CancerPPD 2.0 SATPdb dbACP iACP-DRLF Antifungipept CAFPdb dbAMP AI4AVP

Sequence_Type

standard

Has_Modification No

Description A 24-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, Peptipedia, AntiCP 2.0, and other sources, with an available 3D structural model.

Sequence

GLFGVLGSIAKHVLPHVVPVIAEK

FASTA

>TPDB10285|Antibacterial;Anticancer;Antifungal;Antiparasitic;Antiviral|length=24
GLFGVLGSIAKHVLPHVVPVIAEK

Formula C118H194N30O28

Absent Amino Acids RNDCQMTWY

Common Amino Acids V

Mass 2481.02

PI 9.88

Basic Residues 4

Acidic Residues 1

Hydrophobic Residues 13

Net Charge +1

Boman Index 3.56

Hydrophobicity 1.037

Aliphatic Index 150.00

Half Life

Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour

Extinction Coefficient Cystines 0

Absorbance 280nm 0.00

Polar Residues 1

number

Amino Acid Distribution

A: 2 R: 0 N: 0 D: 0 C: 0 E: 1 Q: 0 G: 3 H: 2 I: 2 L: 3 K: 2 M: 0 F: 1 P: 2 S: 1 T: 0 W: 0 Y: 0 V: 5

Length

Formula

C118H194N30O28

Mass

2481.02

9.88

Net Charge

Boman Index

3.56

Hydrophobicity

1.037

C_terminal_Modification

Free

Chirality

Linear_or_Cyclic

Not Available

N_terminal_Modification

Free

Nature

Anticancer

Origin

Litoria chloris, Australia

Evidence 1 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 12 µg/mL

Target

Target Organism M. luteus

Source & Reference

Database Source dbAMP

Other

Source Activity Label	Source Definition
Antibacterial	dbAMP classified as Antibacterial under the Anti-bacterial function class.

Evidence Text

Activity against M. luteus (MIC 12 ug/ml), S. aureus or MRSA (MIC 12 ug/ml), L. innocua (MIC 25 ug/ml), S. epidermidis (MIC 25 ug/m

Evidence 2 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 12 µg/mL

Target

Target Organism Staphylococcus aureus or MRSA

Source & Reference

Database Source dbAMP

Other

Evidence Text

Activity against M. luteus (MIC 12 ug/ml), S. aureus or MRSA (MIC 12 ug/ml), L. innocua (MIC 25 ug/ml), S. epidermidis (MIC 25 ug/ml), S. uberis (MIC 25 ug/ml) and B

Evidence 3 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 25 µg/mL

Target

Target Organism L. innocua

Source & Reference

Database Source dbAMP

Other

Evidence Text

Activity against M. luteus (MIC 12 ug/ml), S. aureus or MRSA (MIC 12 ug/ml), L. innocua (MIC 25 ug/ml), S. epidermidis (MIC 25 ug/ml), S. uberis (MIC 25 ug/ml) and B. cereus (MIC 50 ug/ml). An

Evidence 4 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 25 µg/mL

Target

Target Organism Staphylococcus epidermidis

Source & Reference

Database Source dbAMP

Other

Evidence Text

st M. luteus (MIC 12 ug/ml), S. aureus or MRSA (MIC 12 ug/ml), L. innocua (MIC 25 ug/ml), S. epidermidis (MIC 25 ug/ml), S. uberis (MIC 25 ug/ml) and B. cereus (MIC 50 ug/ml). Antibiofilm:bacteria: inhibited b

Evidence 5 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 25 µg/mL

Target

Target Organism S. uberis

Source & Reference

Database Source dbAMP

Other

Evidence Text

aureus or MRSA (MIC 12 ug/ml), L. innocua (MIC 25 ug/ml), S. epidermidis (MIC 25 ug/ml), S. uberis (MIC 25 ug/ml) and B. cereus (MIC 50 ug/ml). Antibiofilm:bacteria: inhibited bacterial biofilm:S. aureus

Evidence 6 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 50 µg/mL

Target

Target Organism B. cereus

Source & Reference

Database Source dbAMP

Other

Evidence Text

), L. innocua (MIC 25 ug/ml), S. epidermidis (MIC 25 ug/ml), S. uberis (MIC 25 ug/ml) and B. cereus (MIC 50 ug/ml). Antibiofilm:bacteria: inhibited bacterial biofilm:S. aureus and inhibited bacterial biof

Evidence 7 Activity

Activity

Activity Raw

Not Available

Detail Source Activity Anticancer

Target

Cancer Type Not Available

Cell Line Not Available

Tissue Affected Not Available

Assay & Model

Assay Not Available

Testing Time Not Available

Source & Reference

Database Source CancerPPD 2.0 dbACP SATPdb

Source CancerPPD2

Year 1998

Other

Source Activity Label	Source Definition
Anticancer	CancerPPD 2.0 manually curated experimentally verified anticancer peptide/protein annotation.

Evidence 8 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 12 µg/mL

Target

Target Organism M. luteus

Source & Reference

Database Source dbAMP CAFPdb Antifungipept

Other

Source Activity Label	Source Definition
Antifungal	dbAMP classified under the Anti-fungal function class.

Evidence Text

Activity against M. luteus (MIC 12 ug/ml), S. aureus or MRSA (MIC 12 ug/ml), L. innocua (MIC 25 ug/ml), S. epidermidis (MIC 25 ug/m

Evidence 9 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 12 µg/mL

Target

Target Organism Staphylococcus aureus or MRSA

Source & Reference

Database Source dbAMP CAFPdb Antifungipept

Other

Evidence Text

Activity against M. luteus (MIC 12 ug/ml), S. aureus or MRSA (MIC 12 ug/ml), L. innocua (MIC 25 ug/ml), S. epidermidis (MIC 25 ug/ml), S. uberis (MIC 25 ug/ml) and B

Evidence 10 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 25 µg/mL

Target

Target Organism L. innocua

Source & Reference

Database Source dbAMP CAFPdb Antifungipept

Other

Evidence Text

Activity against M. luteus (MIC 12 ug/ml), S. aureus or MRSA (MIC 12 ug/ml), L. innocua (MIC 25 ug/ml), S. epidermidis (MIC 25 ug/ml), S. uberis (MIC 25 ug/ml) and B. cereus (MIC 50 ug/ml). An

Evidence 11 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 25 µg/mL

Target

Target Organism Staphylococcus epidermidis

Source & Reference

Database Source dbAMP CAFPdb Antifungipept

Other

Evidence Text

Evidence 12 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 25 µg/mL

Target

Target Organism S. uberis

Source & Reference

Database Source dbAMP CAFPdb Antifungipept

Other

Evidence Text

Evidence 13 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 50 µg/mL

Target

Target Organism B. cereus

Source & Reference

Database Source dbAMP CAFPdb Antifungipept

Other

Evidence Text

Evidence 14 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 12 µg/mL

Target

Target Organism M. luteus

Source & Reference

Database Source NA

Other

Evidence Text

Activity against M. luteus (MIC 12 ug/ml), S. aureus or MRSA (MIC 12 ug/ml), L. innocua (MIC 25 ug/ml), S. epidermidis (MIC 25 ug/m

Evidence 15 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 12 µg/mL

Target

Target Organism Staphylococcus aureus or MRSA

Source & Reference

Database Source NA

Other

Evidence Text

Activity against M. luteus (MIC 12 ug/ml), S. aureus or MRSA (MIC 12 ug/ml), L. innocua (MIC 25 ug/ml), S. epidermidis (MIC 25 ug/ml), S. uberis (MIC 25 ug/ml) and B

Evidence 16 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 25 µg/mL

Target

Target Organism L. innocua

Source & Reference

Database Source NA

Other

Evidence Text

Activity against M. luteus (MIC 12 ug/ml), S. aureus or MRSA (MIC 12 ug/ml), L. innocua (MIC 25 ug/ml), S. epidermidis (MIC 25 ug/ml), S. uberis (MIC 25 ug/ml) and B. cereus (MIC 50 ug/ml). An

Evidence 17 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 25 µg/mL

Target

Target Organism Staphylococcus epidermidis

Source & Reference

Database Source NA

Other

Evidence Text

Evidence 18 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 25 µg/mL

Target

Target Organism S. uberis

Source & Reference

Database Source NA

Other

Evidence Text

Evidence 19 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 50 µg/mL

Target

Target Organism B. cereus

Source & Reference

Database Source NA

Other

Evidence Text

Evidence 20 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiviral

Activity Measurement 12 µg/mL

Target

Target Organism M. luteus

Source & Reference

Database Source NA

Other

Evidence Text

Activity against M. luteus (MIC 12 ug/ml), S. aureus or MRSA (MIC 12 ug/ml), L. innocua (MIC 25 ug/ml), S. epidermidis (MIC 25 ug/m

Evidence 21 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiviral

Activity Measurement 12 µg/mL

Target

Target Organism Staphylococcus aureus or MRSA

Source & Reference

Database Source NA

Other

Evidence Text

Activity against M. luteus (MIC 12 ug/ml), S. aureus or MRSA (MIC 12 ug/ml), L. innocua (MIC 25 ug/ml), S. epidermidis (MIC 25 ug/ml), S. uberis (MIC 25 ug/ml) and B

Evidence 22 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiviral

Activity Measurement 25 µg/mL

Target

Target Organism L. innocua

Source & Reference

Database Source NA

Other

Evidence Text

Activity against M. luteus (MIC 12 ug/ml), S. aureus or MRSA (MIC 12 ug/ml), L. innocua (MIC 25 ug/ml), S. epidermidis (MIC 25 ug/ml), S. uberis (MIC 25 ug/ml) and B. cereus (MIC 50 ug/ml). An

Evidence 23 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiviral

Activity Measurement 25 µg/mL

Target

Target Organism Staphylococcus epidermidis

Source & Reference

Database Source NA

Other

Evidence Text

Evidence 24 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiviral

Activity Measurement 25 µg/mL

Target

Target Organism S. uberis

Source & Reference

Database Source NA

Other

Evidence Text

Evidence 25 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiviral

Activity Measurement 50 µg/mL

Target

Target Organism B. cereus

Source & Reference

Database Source NA

Other

Evidence Text