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Peptide record

TPDB10281

Antibacterial Anticancer Antifungal Antiparasitic Hemolysis Toxicity standard
24 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB10281
Antibacterial Anticancer Antifungal Antiparasitic Hemolysis Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia Antifungipept CAFPdb APD_complete APD_hemolytic HemoPI Hemolytic2 PD_Hemolysis ToxinPred 3.0
standard
No
A 24-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
VIPFVASVAAEMMQHVYCAASKKC
Physicochemical Analysis
C114H183N29O31S4
RNDGLTW
A
2584.12
8.28
3
1
14
+1
2.36
0.808
85.42
Mammalian: 100 hour Yeast: >20 hour E.coli: >10 hour
1615
62.50
6
Residue Composition
number
5
A
0
R
0
N
0
D
2
C
1
E
1
Q
0
G
1
H
1
I
0
L
2
K
2
M
1
F
1
P
2
S
0
T
0
W
1
Y
4
V
Amino Acid Distribution
A: 5 R: 0 N: 0 D: 0 C: 2 E: 1 Q: 1 G: 0 H: 1 I: 1 L: 0 K: 2 M: 2 F: 1 P: 1 S: 2 T: 0 W: 0 Y: 1 V: 4
Chemical Descriptors
24
C114H183N29O31S4
2584.12
8.28
+1
2.36
0.808
Evidence Records 29 records
Evidence 1 Activity

Activity

MIC
Antibacterial
3.5 µg/mL

Target

Escherichia coli

Source & Reference

dbAMP DRAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class. DRAMP antibacterial activity supported by MIC records against bacterial target organisms.
active against E. coli (MIC 3.5 ug/ml), S. aureus (MIC 3.5 ug/ml), B. subtilis (MIC 1.8 ug/ml), and C. albicans (MIC 1.8 ug/ml).
Evidence 2 Activity

Activity

MIC
Antibacterial
3.5 µg/mL

Target

Staphylococcus aureus

Source & Reference

dbAMP DRAMP

Other

active against E. coli (MIC 3.5 ug/ml), S. aureus (MIC 3.5 ug/ml), B. subtilis (MIC 1.8 ug/ml), and C. albicans (MIC 1.8 ug/ml). Also active against B. pyo
Evidence 3 Activity

Activity

MIC
Antibacterial
1.8 µg/mL

Target

B. subtilis

Source & Reference

dbAMP DRAMP

Other

active against E. coli (MIC 3.5 ug/ml), S. aureus (MIC 3.5 ug/ml), B. subtilis (MIC 1.8 ug/ml), and C. albicans (MIC 1.8 ug/ml). Also active against B. pyocyaneus or P. aeruginosa (MIC
Evidence 4 Activity

Activity

MIC
Antibacterial
1.8 µg/mL

Target

Candida albicans

Source & Reference

dbAMP DRAMP

Other

inst E. coli (MIC 3.5 ug/ml), S. aureus (MIC 3.5 ug/ml), B. subtilis (MIC 1.8 ug/ml), and C. albicans (MIC 1.8 ug/ml). Also active against B. pyocyaneus or P. aeruginosa (MIC 5.2 ug/ml), E. coli (MIC 10.4 ug
Evidence 5 Activity

Activity

MIC
Antibacterial
5.2 µg/mL

Target

Pseudomonas aeruginosa

Source & Reference

dbAMP DRAMP

Other

is (MIC 1.8 ug/ml), and C. albicans (MIC 1.8 ug/ml). Also active against B. pyocyaneus or P. aeruginosa (MIC 5.2 ug/ml), E. coli (MIC 10.4 ug/ml), S. aureus (MIC 20.8 ug/ml), and C. albicans (MIC 10.4 uM). Fou
Evidence 6 Activity

Activity

MIC
Antibacterial
10.4 µg/mL

Target

Escherichia coli

Source & Reference

dbAMP DRAMP

Other

cans (MIC 1.8 ug/ml). Also active against B. pyocyaneus or P. aeruginosa (MIC 5.2 ug/ml), E. coli (MIC 10.4 ug/ml), S. aureus (MIC 20.8 ug/ml), and C. albicans (MIC 10.4 uM). Found in multiple species (th
Evidence 7 Activity

Activity

MIC
Antibacterial
20.8 µg/mL

Target

Staphylococcus aureus

Source & Reference

dbAMP DRAMP

Other

active against B. pyocyaneus or P. aeruginosa (MIC 5.2 ug/ml), E. coli (MIC 10.4 ug/ml), S. aureus (MIC 20.8 ug/ml), and C. albicans (MIC 10.4 uM). Found in multiple species (this ref Quan Z et al. 2008 P
Evidence 8 Activity

Activity

MIC
Antibacterial
10.4 µM

Target

Candida albicans

Source & Reference

dbAMP DRAMP

Other

P. aeruginosa (MIC 5.2 ug/ml), E. coli (MIC 10.4 ug/ml), S. aureus (MIC 20.8 ug/ml), and C. albicans (MIC 10.4 uM). Found in multiple species (this ref Quan Z et al. 2008 Peptides 29:1456-60 in H. schmac
Evidence 9 Activity

Activity

MIC
Antifungal
3.5 µg/mL

Target

Escherichia coli

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class. DRAMP antifungal activity supported by activity records against fungal target organisms.
active against E. coli (MIC 3.5 ug/ml), S. aureus (MIC 3.5 ug/ml), B. subtilis (MIC 1.8 ug/ml), and C. albicans (MIC 1.8 ug/ml).
Evidence 10 Activity

Activity

MIC
Antifungal
3.5 µg/mL

Target

Staphylococcus aureus

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

active against E. coli (MIC 3.5 ug/ml), S. aureus (MIC 3.5 ug/ml), B. subtilis (MIC 1.8 ug/ml), and C. albicans (MIC 1.8 ug/ml). Also active against B. pyo
Evidence 11 Activity

Activity

MIC
Antifungal
1.8 µg/mL

Target

B. subtilis

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

active against E. coli (MIC 3.5 ug/ml), S. aureus (MIC 3.5 ug/ml), B. subtilis (MIC 1.8 ug/ml), and C. albicans (MIC 1.8 ug/ml). Also active against B. pyocyaneus or P. aeruginosa (MIC
Evidence 12 Activity

Activity

MIC
Antifungal
1.8 µg/mL

Target

Candida albicans

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

inst E. coli (MIC 3.5 ug/ml), S. aureus (MIC 3.5 ug/ml), B. subtilis (MIC 1.8 ug/ml), and C. albicans (MIC 1.8 ug/ml). Also active against B. pyocyaneus or P. aeruginosa (MIC 5.2 ug/ml), E. coli (MIC 10.4 ug
Evidence 13 Activity

Activity

MIC
Antifungal
5.2 µg/mL

Target

Pseudomonas aeruginosa

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

is (MIC 1.8 ug/ml), and C. albicans (MIC 1.8 ug/ml). Also active against B. pyocyaneus or P. aeruginosa (MIC 5.2 ug/ml), E. coli (MIC 10.4 ug/ml), S. aureus (MIC 20.8 ug/ml), and C. albicans (MIC 10.4 uM). Fou
Evidence 14 Activity

Activity

MIC
Antifungal
10.4 µg/mL

Target

Escherichia coli

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

cans (MIC 1.8 ug/ml). Also active against B. pyocyaneus or P. aeruginosa (MIC 5.2 ug/ml), E. coli (MIC 10.4 ug/ml), S. aureus (MIC 20.8 ug/ml), and C. albicans (MIC 10.4 uM). Found in multiple species (th
Evidence 15 Activity

Activity

MIC
Antifungal
20.8 µg/mL

Target

Staphylococcus aureus

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

active against B. pyocyaneus or P. aeruginosa (MIC 5.2 ug/ml), E. coli (MIC 10.4 ug/ml), S. aureus (MIC 20.8 ug/ml), and C. albicans (MIC 10.4 uM). Found in multiple species (this ref Quan Z et al. 2008 P
Evidence 16 Activity

Activity

MIC
Antifungal
10.4 µM

Target

Candida albicans

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

P. aeruginosa (MIC 5.2 ug/ml), E. coli (MIC 10.4 ug/ml), S. aureus (MIC 20.8 ug/ml), and C. albicans (MIC 10.4 uM). Found in multiple species (this ref Quan Z et al. 2008 Peptides 29:1456-60 in H. schmac
Evidence 17 Activity

Activity

MIC
Antiparasitic
3.5 µg/mL

Target

Escherichia coli

Source & Reference

DRAMP

Other

Source Activity Label Source Definition
Antiparasitic
DRAMP antiparasitic activity supported by activity records against parasitic targets.
active against E. coli (MIC 3.5 ug/ml), S. aureus (MIC 3.5 ug/ml), B. subtilis (MIC 1.8 ug/ml), and C. albicans (MIC 1.8 ug/ml).
Evidence 18 Activity

Activity

MIC
Antiparasitic
3.5 µg/mL

Target

Staphylococcus aureus

Source & Reference

DRAMP

Other

active against E. coli (MIC 3.5 ug/ml), S. aureus (MIC 3.5 ug/ml), B. subtilis (MIC 1.8 ug/ml), and C. albicans (MIC 1.8 ug/ml). Also active against B. pyo
Evidence 19 Activity

Activity

MIC
Antiparasitic
1.8 µg/mL

Target

B. subtilis

Source & Reference

DRAMP

Other

active against E. coli (MIC 3.5 ug/ml), S. aureus (MIC 3.5 ug/ml), B. subtilis (MIC 1.8 ug/ml), and C. albicans (MIC 1.8 ug/ml). Also active against B. pyocyaneus or P. aeruginosa (MIC
Evidence 20 Activity

Activity

MIC
Antiparasitic
1.8 µg/mL

Target

Candida albicans

Source & Reference

DRAMP

Other

inst E. coli (MIC 3.5 ug/ml), S. aureus (MIC 3.5 ug/ml), B. subtilis (MIC 1.8 ug/ml), and C. albicans (MIC 1.8 ug/ml). Also active against B. pyocyaneus or P. aeruginosa (MIC 5.2 ug/ml), E. coli (MIC 10.4 ug
Evidence 21 Activity

Activity

MIC
Antiparasitic
5.2 µg/mL

Target

Pseudomonas aeruginosa

Source & Reference

DRAMP

Other

is (MIC 1.8 ug/ml), and C. albicans (MIC 1.8 ug/ml). Also active against B. pyocyaneus or P. aeruginosa (MIC 5.2 ug/ml), E. coli (MIC 10.4 ug/ml), S. aureus (MIC 20.8 ug/ml), and C. albicans (MIC 10.4 uM). Fou
Evidence 22 Activity

Activity

MIC
Antiparasitic
10.4 µg/mL

Target

Escherichia coli

Source & Reference

DRAMP

Other

cans (MIC 1.8 ug/ml). Also active against B. pyocyaneus or P. aeruginosa (MIC 5.2 ug/ml), E. coli (MIC 10.4 ug/ml), S. aureus (MIC 20.8 ug/ml), and C. albicans (MIC 10.4 uM). Found in multiple species (th
Evidence 23 Activity

Activity

MIC
Antiparasitic
20.8 µg/mL

Target

Staphylococcus aureus

Source & Reference

DRAMP

Other

active against B. pyocyaneus or P. aeruginosa (MIC 5.2 ug/ml), E. coli (MIC 10.4 ug/ml), S. aureus (MIC 20.8 ug/ml), and C. albicans (MIC 10.4 uM). Found in multiple species (this ref Quan Z et al. 2008 P
Evidence 24 Activity

Activity

MIC
Antiparasitic
10.4 µM

Target

Candida albicans

Source & Reference

DRAMP

Other

P. aeruginosa (MIC 5.2 ug/ml), E. coli (MIC 10.4 ug/ml), S. aureus (MIC 20.8 ug/ml), and C. albicans (MIC 10.4 uM). Found in multiple species (this ref Quan Z et al. 2008 Peptides 29:1456-60 in H. schmac
Evidence 25 Activity

Activity

% Hemolysis
Hemolysis
2.9 %
[Ref.17272268] RCH=11.2 ± 2.9% against rabbit red blood cells. RCH, red cell hemolysis.

Target

rabbit red blood cells

Source & Reference

Hemolytik APD_complete APD_hemolytic PD_Hemolysis
DRAMP4
Mol Cell Proteomics. 2007 May 6(5):882-894.

Other

Source Activity Label Source Definition
Hemolysis
APD_complete APD-derived hemolytic peptide annotation. APD_hemolytic APD hemolytic peptide annotation. Hemolytik experimentally validated hemolytic peptide annotation.
Evidence 26 Activity

Activity

11% Hemolysis
Toxicity
50 µg/mL
Hemolytic Cytotoxic
11% Hemolysis | 50 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Anti-infection peptidomics of amphibian skin. | Mol Cell Proteomics | 2007
Evidence 27 Activity

Activity

(6.9±3.4)% degranulation
Toxicity
50 µg/mL
Cytotoxic
(6.9±3.4)% degranulation | 50 | µg/mL | target cell: Human mast cells

Target

Human mast cells

Source & Reference

NA
DBAASP
Anti-infection peptidomics of amphibian skin. | Mol Cell Proteomics | 2007
Evidence 28 Activity

Activity

Toxicity
Hemolytic
Hemolytic_activity: [Ref.17272268] RCH=11.2 ± 2.9% against rabbit red blood cells. RCH, red cell hemolysis.

Target

erythrocytes

Source & Reference

NA
DRAMP
Mol Cell Proteomics. 2007 May 6(5):882-894.
Evidence 29 Hemolysis

Activity

2.9 %
% Hemolysis
[Ref.17272268] RCH=11.2 ± 2.9% against rabbit red blood cells. RCH, red cell hemolysis.
Hemolysis

Target

rabbit red blood cells

Source & Reference

APD_complete APD_hemolytic HemoPI PD_Hemolysis
Mol Cell Proteomics. 2007 May 6(5):882-894.
DRAMP4
APD_complete APD_hemolytic PD_Hemolysis

Other

Source Activity Label Source Definition
Hemolysis
APD_complete APD-derived hemolytic peptide annotation. APD_hemolytic APD hemolytic peptide annotation.