TPDB

3D PDB MODEL

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TPDB ID TPDB10272

Activity

Antibacterial Hemolysis Toxicity

Activity_category_statistics

Anti-infective peptides Toxicity and safety peptides

Database_Source

AntiBP3 Peptipedia PD_Hemolysis

Sequence_Type

standard

Has_Modification No

Description A 24-aa standard natural multi-activity (Antibacterial, Hemolysis, and Toxicity) peptide sequence curated from AntiBP3, Peptipedia, and PD_Hemolysis, with an available 3D structural model.

Sequence

KIAGKIASIAGKIAKIAGKIAKIA

FASTA

>TPDB10272|Antibacterial;Hemolysis;Toxicity|length=24
KIAGKIASIAGKIAKIAGKIAKIA

Formula C108H200N30O26

Absent Amino Acids RNDCEQHLMFPTWYV

Common Amino Acids AI

Mass 2334.96

PI 11.21

Basic Residues 6

Acidic Residues 0

Hydrophobic Residues 14

Net Charge +6

Boman Index 2.74

Hydrophobicity 0.779

Aliphatic Index 142.92

Half Life

Mammalian: 1.3 hour Yeast: 3 min E.coli: 2 min

Extinction Coefficient Cystines 0

Absorbance 280nm 0.00

Polar Residues 1

number

7

A

0

R

0

N

0

D

0

C

0

E

0

Q

3

G

0

H

7

I

0

L

6

K

0

M

0

F

0

P

1

S

0

T

0

W

0

Y

0

V

Amino Acid Distribution

A: 7 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 3 H: 0 I: 7 L: 0 K: 6 M: 0 F: 0 P: 0 S: 1 T: 0 W: 0 Y: 0 V: 0

Length

24

Formula

C108H200N30O26

Mass

2334.96

PI

11.21

Net Charge

+6

Boman Index

2.74

Hydrophobicity

0.779

Evidence 1 Activity

Activity

Activity Endpoint 24% Hemolysis

Detail Source Activity Toxicity

Activity Measurement 8 µg/mL

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

24% Hemolysis | 8 | µg/mL | target cell: Human erythrocytes

Target

Target Cell Human erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Influence of the Length and Charge on the Activity of ?-Helical Amphipathic Antimicrobial Peptides. | Biochemistry | 2017

Evidence 2 Activity

Activity

Activity Endpoint 44% Hemolysis

Detail Source Activity Toxicity

Activity Measurement 32 µg/mL

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

44% Hemolysis | 32 | µg/mL | target cell: Human erythrocytes

Target

Target Cell Human erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Influence of the Length and Charge on the Activity of ?-Helical Amphipathic Antimicrobial Peptides. | Biochemistry | 2017

Evidence 3 Activity

Activity

Activity Endpoint 89% Hemolysis

Detail Source Activity Toxicity

Activity Measurement 128 µg/mL

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

89% Hemolysis | 128 | µg/mL | target cell: Human erythrocytes

Target

Target Cell Human erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Influence of the Length and Charge on the Activity of ?-Helical Amphipathic Antimicrobial Peptides. | Biochemistry | 2017

Evidence 4 Activity

Activity

Activity Endpoint 100% Hemolysis

Detail Source Activity Toxicity

Activity Measurement 512 µg/mL

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

100% Hemolysis | 512 | µg/mL | target cell: Human erythrocytes

Target

Target Cell Human erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Influence of the Length and Charge on the Activity of ?-Helical Amphipathic Antimicrobial Peptides. | Biochemistry | 2017

Evidence 5 Hemolysis

Source & Reference

source PD_Hemolysis

Database Source PD_Hemolysis