TPDB

3D PDB MODEL

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TPDB ID TPDB10263

Activity

Antibacterial Anticancer Antifungal Hemolysis Toxicity

Activity_category_statistics

Anti-infective peptides Cancer-related peptides Toxicity and safety peptides

Database_Source

AntiBP3 Peptipedia Antifungipept CAFPdb dbAMP HemoPI Hemolytic2 PD_Hemolysis

Sequence_Type

standard

Has_Modification No

Description A 24-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, Peptipedia, Antifungipept, and other sources, with an available 3D structural model.

Sequence

FLPILASLAAKFGPKLFSLVTKKS

FASTA

>TPDB10263|Antibacterial;Anticancer;Antifungal;Hemolysis;Toxicity|length=24
FLPILASLAAKFGPKLFSLVTKKS

Formula C126H206N28O29

Absent Amino Acids RNDCEQHMWY

Common Amino Acids L

Mass 2577.19

PI 11.00

Basic Residues 4

Acidic Residues 0

Hydrophobic Residues 13

Net Charge +4

Boman Index -1.54

Hydrophobicity 0.800

Aliphatic Index 122.08

Half Life

Mammalian: 1.1 hour Yeast: 3 min E.coli: 2 min

Extinction Coefficient Cystines 0

Absorbance 280nm 0.00

Polar Residues 4

number

3

A

0

R

0

N

0

D

0

C

0

E

0

Q

1

G

0

H

1

I

5

L

4

K

0

M

3

F

2

P

3

S

1

T

0

W

0

Y

1

V

Amino Acid Distribution

A: 3 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 1 H: 0 I: 1 L: 5 K: 4 M: 0 F: 3 P: 2 S: 3 T: 1 W: 0 Y: 0 V: 1

Length

24

Formula

C126H206N28O29

Mass

2577.19

PI

11.00

Net Charge

+4

Boman Index

-1.54

Hydrophobicity

0.800

Evidence 1 Activity

Activity

Activity Endpoint LC50

Detail Source Activity Hemolysis

Activity Measurement 75 µM

Hemolysis Raw

Human erythrocytes: LC50=75 µM

Target

RBC Target Human erythrocytes

Source & Reference

Database Source Hemolytik PD_Hemolysis

Source DRAMP4

Reference

Eur Biophys J. 2011 Apr 40(4):555-64.

Other

Source Activity Label	Source Definition
Hemolysis	Hemolytik experimentally validated hemolytic peptide annotation.

Evidence 2 Activity

Activity

Activity Endpoint 50% Hemolysis

Detail Source Activity Toxicity

Activity Measurement 75 µM

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

50% Hemolysis | 75 | µM | target cell: Human erythrocytes

Target

Target Cell Human erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Synthesis, conformational analysis and biological properties of a dicarba derivative of the antimicrobial peptide, brevinin-1BYa. | Eur Biophys J | 2011

Evidence 3 Activity

Activity

Activity Endpoint LC50

Detail Source Activity Toxicity

Activity Measurement 75 µM

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

Hemolytic_activity: Human erythrocytes: LC50=75 µM | Cytotoxicity: Not available

Target

Target Cell erythrocytes

Source & Reference

Database Source NA

Source Database DRAMP

Reference

Eur Biophys J. 2011 Apr 40(4):555-64.

Evidence 4 Hemolysis

Activity

Activity Measurement 75 µM

Activity Endpoint LC50

Hemolysis Raw

Human erythrocytes: LC50=75 µM

Detail Source Activity Hemolysis

Target

RBC Target Human erythrocytes

Source & Reference

source HemoPI PD_Hemolysis

Reference

Eur Biophys J. 2011 Apr 40(4):555-64.

Source DRAMP4

Database Source PD_Hemolysis