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Peptide record

TPDB10258

Antibacterial Antifungal Hemolysis Toxicity standard
24 amino acids
Basic Information
3D PDB MODEL
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TPDB10258
Antibacterial Antifungal Hemolysis Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 Peptipedia Antifungipept CAFPdb dbAMP APD_complete APD_hemolytic HemoPI Hemolytic2 PD_Hemolysis ToxinPred 3.0
standard
No
A 24-aa standard natural multi-activity (Antibacterial, Antifungal, Hemolysis, and other sources) peptide sequence curated from AntiBP3, Peptipedia, Antifungipept, and other sources, with an available 3D structural model.
Sequence
FMGTALKIAANVLPAAFCKIFKKC
Physicochemical Analysis
C121H197N29O27S3
RDEQHSWY
A
2586.25
10.17
4
0
14
+4
-1.64
0.971
97.92
Mammalian: 1.1 hour Yeast: 3 min E.coli: 2 min
125
4.83
4
Residue Composition
number
5
A
0
R
1
N
0
D
2
C
0
E
0
Q
1
G
0
H
2
I
2
L
4
K
1
M
3
F
1
P
0
S
1
T
0
W
0
Y
1
V
Amino Acid Distribution
A: 5 R: 0 N: 1 D: 0 C: 2 E: 0 Q: 0 G: 1 H: 0 I: 2 L: 2 K: 4 M: 1 F: 3 P: 1 S: 0 T: 1 W: 0 Y: 0 V: 1
Chemical Descriptors
24
C121H197N29O27S3
2586.25
10.17
+4
-1.64
0.971
Evidence Records 10 records
Evidence 1 Activity

Activity

MIC
Antibacterial
3.1 µM

Target

Staphylococcus aureus ATCC 25923

Source & Reference

dbAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class.
Active against S. aureus ATCC 25923 (MIC 3.1 uM), E. faecium 091299 (IS) (MIC 100 uM), E. faecalis 981 (IS) (MIC 3.1 uM), N. asteroides 20
Evidence 2 Activity

Activity

MIC
Antibacterial
200 µM

Target

E.coli ATCC 25922

Source & Reference

dbAMP

Other

MIC 400 uM), K.Pneumoniae 08040724 (IS) (MIC 400 uM), E. cloacae CGMCC 1.57 (MIC 100 uM), E.coli ATCC 25922 (MIC 200 uM), P. faecalis X29 (IS) (MIC 12.5 uM), C. glabrata 090902 (IS) (MIC 12.5 uM), C. albicans A
Evidence 3 Activity

Activity

MIC
Antibacterial
100 µM

Target

Candida albicans ATCC10231

Source & Reference

dbAMP

Other

(MIC 200 uM), P. faecalis X29 (IS) (MIC 12.5 uM), C. glabrata 090902 (IS) (MIC 12.5 uM), C. albicans ATCC10231 (MIC100 uM). IS= Isolated strain.
Evidence 4 Activity

Activity

MIC
Antifungal
3.1 µM

Target

Staphylococcus aureus ATCC 25923

Source & Reference

dbAMP CAFPdb Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class.
Active against S. aureus ATCC 25923 (MIC 3.1 uM), E. faecium 091299 (IS) (MIC 100 uM), E. faecalis 981 (IS) (MIC 3.1 uM), N. asteroides 20
Evidence 5 Activity

Activity

MIC
Antifungal
200 µM

Target

E.coli ATCC 25922

Source & Reference

dbAMP CAFPdb Antifungipept

Other

MIC 400 uM), K.Pneumoniae 08040724 (IS) (MIC 400 uM), E. cloacae CGMCC 1.57 (MIC 100 uM), E.coli ATCC 25922 (MIC 200 uM), P. faecalis X29 (IS) (MIC 12.5 uM), C. glabrata 090902 (IS) (MIC 12.5 uM), C. albicans A
Evidence 6 Activity

Activity

MIC
Antifungal
100 µM

Target

Candida albicans ATCC10231

Source & Reference

dbAMP CAFPdb Antifungipept

Other

(MIC 200 uM), P. faecalis X29 (IS) (MIC 12.5 uM), C. glabrata 090902 (IS) (MIC 12.5 uM), C. albicans ATCC10231 (MIC100 uM). IS= Isolated strain.
Evidence 7 Activity

Activity

52% Hemolysis
Toxicity
50 µM
Hemolytic Cytotoxic
52% Hemolysis | 50 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Identification of multiple antimicrobial peptides from the skin of fine-spined frog, Hylarana spinulosa (Ranidae). | Biochimie | 2013
Evidence 8 Activity

Activity

91% Hemolysis
Toxicity
100 µM
Hemolytic Cytotoxic
91% Hemolysis | 100 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Identification of multiple antimicrobial peptides from the skin of fine-spined frog, Hylarana spinulosa (Ranidae). | Biochimie | 2013
Evidence 9 Activity

Activity

100% Hemolysis
Toxicity
200 µM
Hemolytic Cytotoxic
100% Hemolysis | 200 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Identification of multiple antimicrobial peptides from the skin of fine-spined frog, Hylarana spinulosa (Ranidae). | Biochimie | 2013
Evidence 10 Hemolysis

Source & Reference

APD_complete APD_hemolytic HemoPI PD_Hemolysis
APD_complete APD_hemolytic PD_Hemolysis

Other

Source Activity Label Source Definition
Hemolysis
APD_complete APD-derived hemolytic peptide annotation. APD_hemolytic APD hemolytic peptide annotation.