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Peptide record

TPDB10246

Antibacterial Toxicity standard

23 amino acids

3D PDB MODEL

Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.

TPDB ID TPDB10246

Activity

Antibacterial Toxicity

Activity_category_statistics

Anti-infective peptides Toxicity and safety peptides

Database_Source

AntiBP3 Peptipedia

Sequence_Type

standard

Has_Modification No

Description A 23-aa standard natural multi-activity (Antibacterial and Toxicity) peptide sequence curated from AntiBP3 and Peptipedia, with an available 3D structural model.

Sequence

RIIDRLWRVRRPQKPKFVIVWVR

FASTA

>TPDB10246|Antibacterial;Toxicity|length=23
RIIDRLWRVRRPQKPKFVIVWVR

Formula C142H234N46O27

Absent Amino Acids ANCEGHMSTY

Common Amino Acids R

Mass 3017.71

PI 12.71

Basic Residues 8

Acidic Residues 1

Hydrophobic Residues 11

Net Charge +7

Boman Index 3.51

Hydrophobicity -0.430

Aliphatic Index 118.26

Half Life

Mammalian: 1 hour Yeast: 2 min E.coli: 2 min

Extinction Coefficient Cystines 11000

Absorbance 280nm 364.51

Polar Residues 1

number

Amino Acid Distribution

A: 0 R: 6 N: 0 D: 1 C: 0 E: 0 Q: 1 G: 0 H: 0 I: 3 L: 1 K: 2 M: 0 F: 1 P: 2 S: 0 T: 0 W: 2 Y: 0 V: 4

Length

Formula

C142H234N46O27

Mass

3017.71

12.71

Net Charge

Boman Index

3.51

Hydrophobicity

-0.430

Evidence 1 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 0.0125 µg/mL

Target

Target Organism Staphylococcus aureus ATCC 25923

Source & Reference

Database Source NA

Other

Evidence Text

Active against S. aureus ATCC 25923 (MIC 0.0125 ug/ml), S. epidermidis LY8 (MIC 12.5 ug/ml), L. monocytogenes CICC 21533 (MIC 62.5 ug/ml), B. su

Evidence 2 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 12.5 µg/mL

Target

Target Organism Staphylococcus epidermidis LY8

Source & Reference

Database Source NA

Other

Evidence Text

Active against S. aureus ATCC 25923 (MIC 0.0125 ug/ml), S. epidermidis LY8 (MIC 12.5 ug/ml), L. monocytogenes CICC 21533 (MIC 62.5 ug/ml), B. subtilis CICC 24434 (MIC 0.78 ug/ml), S

Evidence 3 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 62.5 µg/mL

Target

Target Organism L. monocytogenes CICC 21533

Source & Reference

Database Source NA

Other

Evidence Text

ive against S. aureus ATCC 25923 (MIC 0.0125 ug/ml), S. epidermidis LY8 (MIC 12.5 ug/ml), L. monocytogenes CICC 21533 (MIC 62.5 ug/ml), B. subtilis CICC 24434 (MIC 0.78 ug/ml), S. enterica serovar Choleraesuis C78-1 or serov

Evidence 4 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 0.78 µg/mL

Target

Target Organism B. subtilis CICC 24434

Source & Reference

Database Source NA

Other

Evidence Text

g/ml), S. epidermidis LY8 (MIC 12.5 ug/ml), L. monocytogenes CICC 21533 (MIC 62.5 ug/ml), B. subtilis CICC 24434 (MIC 0.78 ug/ml), S. enterica serovar Choleraesuis C78-1 or serovar Typhimurium SL1344 (MIC 0.39-0.78 ug/m

Evidence 5 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 0.39-0.78 µg/mL

Target

Target Organism S. enterica serovar Choleraesuis C78-1 or serovar Typhimurium SL1344

Source & Reference

Database Source NA

Other

Evidence Text

), L. monocytogenes CICC 21533 (MIC 62.5 ug/ml), B. subtilis CICC 24434 (MIC 0.78 ug/ml), S. enterica serovar Choleraesuis C78-1 or serovar Typhimurium SL1344 (MIC 0.39-0.78 ug/ml), P. multocida C48-3 (MIC 0.78 ug/ml), enterotoxigenic E. coli E44813 (MIC 6.25 ug/ml), an

Evidence 6 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 0.78 µg/mL

Target

Target Organism P. multocida C48-3

Source & Reference

Database Source NA

Other

Evidence Text

enterica serovar Choleraesuis C78-1 or serovar Typhimurium SL1344 (MIC 0.39-0.78 ug/ml), P. multocida C48-3 (MIC 0.78 ug/ml), enterotoxigenic E. coli E44813 (MIC 6.25 ug/ml), and S. flexneri CICC 21534 (MIC 75 ug/m

Evidence 7 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 6.25 µg/mL

Target

Target Organism Escherichia coli E44813

Source & Reference

Database Source NA

Other

Evidence Text

murium SL1344 (MIC 0.39-0.78 ug/ml), P. multocida C48-3 (MIC 0.78 ug/ml), enterotoxigenic E. coli E44813 (MIC 6.25 ug/ml), and S. flexneri CICC 21534 (MIC 75 ug/ml).

Evidence 8 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 75 µg/mL

Target

Target Organism S. flexneri CICC 21534

Source & Reference

Database Source NA

Other

Evidence Text

P. multocida C48-3 (MIC 0.78 ug/ml), enterotoxigenic E. coli E44813 (MIC 6.25 ug/ml), and S. flexneri CICC 21534 (MIC 75 ug/ml).

Evidence 9 Activity

Activity

Activity Endpoint <4% Hemolysis

Detail Source Activity Toxicity

Activity Measurement 1000 µg/mL

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

<4% Hemolysis | 1000 | µg/mL | target cell: Mouse erythrocytes

Target

Target Cell Mouse erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Analogs of the Cathelicidin-Derived Antimicrobial Peptide PMAP-23 Exhibit Improved Stability and Antibacterial Activity. | Probiotics Antimicrob Proteins | 2020

Evidence 10 Activity

Activity

Activity Endpoint <10% Killing

Detail Source Activity Toxicity

Activity Measurement 500 µg/mL

Toxicity Type Cytotoxic

Toxicity Raw

<10% Killing | 500 | µg/mL | target cell: Mouse fibroblasts NIH 3T3

Target

Target Cell Mouse fibroblasts NIH 3T3

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Analogs of the Cathelicidin-Derived Antimicrobial Peptide PMAP-23 Exhibit Improved Stability and Antibacterial Activity. | Probiotics Antimicrob Proteins | 2020