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Peptide record

TPDB10236

Antibacterial Toxicity standard
23 amino acids
Basic Information
3D PDB MODEL
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TPDB10236
Antibacterial Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia
standard
No
A 23-aa standard natural multi-activity (Antibacterial and Toxicity) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
GIGKFLHSAKKWGKAFVGEIMNS
Physicochemical Analysis
C116H181N31O29S1
RDCQPTY
GK
2505.96
10.55
5
1
10
+3
1.87
-0.078
72.17
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
5500
219.48
3
Residue Composition
number
2
A
0
R
1
N
0
D
0
C
1
E
0
Q
4
G
1
H
2
I
1
L
4
K
1
M
2
F
0
P
2
S
0
T
1
W
0
Y
1
V
Amino Acid Distribution
A: 2 R: 0 N: 1 D: 0 C: 0 E: 1 Q: 0 G: 4 H: 1 I: 2 L: 1 K: 4 M: 1 F: 2 P: 0 S: 2 T: 0 W: 1 Y: 0 V: 1
Chemical Descriptors
23
C116H181N31O29S1
2505.96
10.55
+3
1.87
-0.078
Evidence Records 3 records
Evidence 1 Activity

Activity

<5% Hemolysis
Toxicity
128 µg/mL
Hemolytic Cytotoxic
<5% Hemolysis | 128 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Design and synthesis of cationic antimicrobial peptides with improved activity and selectivity against Vibrio spp. | Int J Antimicrob Agents | 2008
Evidence 2 Activity

Activity

Toxicity
Hemolytic
NA | target cell: Rabbit erythrocytes

Target

Rabbit erythrocytes

Source & Reference

NA
DBAASP
Parallel and antiparallel dimers of magainin 2: their interaction with phospholipid membrane and antibacterial activity. | J Pept Sci | 2002
Evidence 3 Activity

Activity

MHC
Toxicity
128 µM
Hemolytic
Hemolytic_activity: [Ref.18586467] MHC=128 µM against human red blood cells

Target

erythrocytes

Source & Reference

NA
DRAMP
Int J Antimicrob Agents. 2008 Aug 32(2):130-8. doi: 10.1016/j.ijantimicag.2008.04.003.