Back to search

Peptide record

TPDB10233

Antibacterial Anticancer Antifungal Antiparasitic Toxicity standard

23 amino acids

3D PDB MODEL

Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.

TPDB ID TPDB10233

Activity

Antibacterial Anticancer Antifungal Antiparasitic Toxicity

Activity_category_statistics

Anti-infective peptides Cancer-related peptides Toxicity and safety peptides

Database_Source

AntiBP3 dbAMP DRAMP Peptipedia AFP-GFuse Antifungipept CAFPdb ToxinPred 3.0

Sequence_Type

standard

Has_Modification No

Description A 23-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.

Sequence

GLHKVMREVLGYERNSYKKFFLR

FASTA

>TPDB10233|Antibacterial;Anticancer;Antifungal;Antiparasitic;Toxicity|length=23
GLHKVMREVLGYERNSYKKFFLR

Formula C132H208N38O32S1

Absent Amino Acids ADCQIPTW

Common Amino Acids RLK

Mass 2871.40

PI 10.55

Basic Residues 7

Acidic Residues 2

Hydrophobic Residues 10

Net Charge +4

Boman Index 5.06

Hydrophobicity -0.687

Aliphatic Index 76.09

Half Life

Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour

Extinction Coefficient Cystines 2980

Absorbance 280nm 103.78

Polar Residues 4

number

Amino Acid Distribution

A: 0 R: 3 N: 1 D: 0 C: 0 E: 2 Q: 0 G: 2 H: 1 I: 0 L: 3 K: 3 M: 1 F: 2 P: 0 S: 1 T: 0 W: 0 Y: 2 V: 2

Length

Formula

C132H208N38O32S1

Mass

2871.40

10.55

Net Charge

Boman Index

5.06

Hydrophobicity

-0.687

Evidence 1 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 30 µg/mL

Target

Target Organism Escherichia coli

Source & Reference

Database Source dbAMP DRAMP

Other

Source Activity Label	Source Definition
Antibacterial	dbAMP classified as Antibacterial under the Anti-bacterial function class. DRAMP antibacterial activity supported by MIC records against bacterial target organisms.

Evidence Text

active against E. coli (MIC 30 ug/ml), S. aureus (MIC 3.7 ug/ml), and C. albicans (MIC 7.5 ug/ml).

Evidence 2 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 3.7 µg/mL

Target

Target Organism Staphylococcus aureus

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

active against E. coli (MIC 30 ug/ml), S. aureus (MIC 3.7 ug/ml), and C. albicans (MIC 7.5 ug/ml).

Evidence 3 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 7.5 µg/mL

Target

Target Organism Candida albicans

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

active against E. coli (MIC 30 ug/ml), S. aureus (MIC 3.7 ug/ml), and C. albicans (MIC 7.5 ug/ml).

Evidence 4 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 30 µg/mL

Target

Target Organism Escherichia coli

Source & Reference

Database Source dbAMP DRAMP CAFPdb Antifungipept

Other

Source Activity Label	Source Definition
Antifungal	dbAMP classified under the Anti-fungal function class. DRAMP antifungal activity supported by activity records against fungal target organisms.

Evidence Text

active against E. coli (MIC 30 ug/ml), S. aureus (MIC 3.7 ug/ml), and C. albicans (MIC 7.5 ug/ml).

Evidence 5 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 3.7 µg/mL

Target

Target Organism Staphylococcus aureus

Source & Reference

Database Source dbAMP DRAMP CAFPdb Antifungipept

Other

Evidence Text

active against E. coli (MIC 30 ug/ml), S. aureus (MIC 3.7 ug/ml), and C. albicans (MIC 7.5 ug/ml).

Evidence 6 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 7.5 µg/mL

Target

Target Organism Candida albicans

Source & Reference

Database Source dbAMP DRAMP CAFPdb Antifungipept

Other

Evidence Text

active against E. coli (MIC 30 ug/ml), S. aureus (MIC 3.7 ug/ml), and C. albicans (MIC 7.5 ug/ml).

Evidence 7 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 30 µg/mL

Target

Target Organism Escherichia coli

Source & Reference

Database Source DRAMP

Other

Source Activity Label	Source Definition
Antiparasitic	DRAMP antiparasitic activity supported by activity records against parasitic targets.

Evidence Text

active against E. coli (MIC 30 ug/ml), S. aureus (MIC 3.7 ug/ml), and C. albicans (MIC 7.5 ug/ml).

Evidence 8 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 3.7 µg/mL

Target

Target Organism Staphylococcus aureus

Source & Reference

Database Source DRAMP

Other

Evidence Text

active against E. coli (MIC 30 ug/ml), S. aureus (MIC 3.7 ug/ml), and C. albicans (MIC 7.5 ug/ml).

Evidence 9 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 7.5 µg/mL

Target

Target Organism Candida albicans

Source & Reference

Database Source DRAMP

Other

Evidence Text

active against E. coli (MIC 30 ug/ml), S. aureus (MIC 3.7 ug/ml), and C. albicans (MIC 7.5 ug/ml).

Evidence 10 Activity

Activity

Detail Source Activity Toxicity

Toxicity Type Cytotoxic

Toxicity Raw

NA | target cell: Human embryonic kidney HEK293 cells

Target

Target Cell Human embryonic kidney HEK293 cells

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Central Role of the Copper-Binding Motif in the Complex Mechanism of Action of Ixosin: Enhancing Oxidative Damage and Promoting Synergy with Ixosin B. | ACS Infect Dis | 2016

Evidence 11 Activity

Activity

Detail Source Activity Toxicity

Toxicity Type Hemolytic

Toxicity Raw

Hemolytic_activity: [Ref.16087274]Little hemolytic activity on rabbit red blood cells up to 50 µg/mL

Target

Target Cell erythrocytes

Source & Reference

Database Source NA

Source Database DRAMP

Reference

Peptides. 2006 Jan 27(1):31-5.