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Peptide record

TPDB10232

Antibacterial Anticancer Antifungal Antiparasitic Toxicity standard
23 amino acids
Basic Information
3D PDB MODEL
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TPDB10232
Antibacterial Anticancer Antifungal Antiparasitic Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia ACP740 _ACP240 AntiCP 2.0 iACP-DRLF AFP-GFuse Antifungipept CAFPdb
standard
No
A 23-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
AFKLLGRIIHHVGNFVYGFSHVF
Physicochemical Analysis
C130H188N34O27
DCEQMPTW
F
2659.13
10.42
5
0
13
+2
-1.90
0.757
110.00
Mammalian: 4.4 hour Yeast: >20 hour E.coli: >10 hour
1490
56.03
3
Residue Composition
number
1
A
1
R
1
N
0
D
0
C
0
E
0
Q
3
G
3
H
2
I
2
L
1
K
0
M
4
F
0
P
1
S
0
T
0
W
1
Y
3
V
Amino Acid Distribution
A: 1 R: 1 N: 1 D: 0 C: 0 E: 0 Q: 0 G: 3 H: 3 I: 2 L: 2 K: 1 M: 0 F: 4 P: 0 S: 1 T: 0 W: 0 Y: 1 V: 3
Chemical Descriptors
23
C130H188N34O27
2659.13
10.42
+2
-1.90
0.757
Evidence Records 15 records
Evidence 1 Activity

Activity

MIC
Antibacterial
64 µg/mL

Target

Escherichia coli ATCC 25922

Source & Reference

dbAMP DRAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class. DRAMP antibacterial activity supported by MIC records against bacterial target organisms.
e ref). More active than Clavanin A or B (see ref). Recent tests reveled activity against E. coli ATCC 25922 (MIC 64 ug/ml), E.faecalis ATCC 29212 (MIC 128 ug/ml), S.aureus ATCC 43300 (MIC 128 ug/ml) [MRSA-inactiv
Evidence 2 Activity

Activity

MIC
Antibacterial
128 µg/mL

Target

Enterococcus faecalis ATCC 29212

Source & Reference

dbAMP DRAMP

Other

or B (see ref). Recent tests reveled activity against E. coli ATCC 25922 (MIC 64 ug/ml), E.faecalis ATCC 29212 (MIC 128 ug/ml), S.aureus ATCC 43300 (MIC 128 ug/ml) [MRSA-inactive], and C. albicans ATCC 10231 (MIC 16
Evidence 3 Activity

Activity

MIC
Antibacterial
128 µg/mL

Target

S.aureus ATCC 43300

Source & Reference

dbAMP DRAMP

Other

ctivity against E. coli ATCC 25922 (MIC 64 ug/ml), E.faecalis ATCC 29212 (MIC 128 ug/ml), S.aureus ATCC 43300 (MIC 128 ug/ml) [MRSA-inactive], and C. albicans ATCC 10231 (MIC 16 ug/ml). Antimicrobial activity was no
Evidence 4 Activity

Activity

MIC
Antibacterial
16 µg/mL

Target

Candida albicans ATCC 10231

Source & Reference

dbAMP DRAMP

Other

alis ATCC 29212 (MIC 128 ug/ml), S.aureus ATCC 43300 (MIC 128 ug/ml) [MRSA-inactive], and C. albicans ATCC 10231 (MIC 16 ug/ml). Antimicrobial activity was not enhanced by metals such as Zn2+ or Cu2+. In the case of E
Evidence 5 Activity

Activity

MIC
Antifungal
64 µg/mL

Target

Escherichia coli ATCC 25922

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class. DRAMP antifungal activity supported by activity records against fungal target organisms.
e ref). More active than Clavanin A or B (see ref). Recent tests reveled activity against E. coli ATCC 25922 (MIC 64 ug/ml), E.faecalis ATCC 29212 (MIC 128 ug/ml), S.aureus ATCC 43300 (MIC 128 ug/ml) [MRSA-inactiv
Evidence 6 Activity

Activity

MIC
Antifungal
128 µg/mL

Target

Enterococcus faecalis ATCC 29212

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

or B (see ref). Recent tests reveled activity against E. coli ATCC 25922 (MIC 64 ug/ml), E.faecalis ATCC 29212 (MIC 128 ug/ml), S.aureus ATCC 43300 (MIC 128 ug/ml) [MRSA-inactive], and C. albicans ATCC 10231 (MIC 16
Evidence 7 Activity

Activity

MIC
Antifungal
128 µg/mL

Target

S.aureus ATCC 43300

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

ctivity against E. coli ATCC 25922 (MIC 64 ug/ml), E.faecalis ATCC 29212 (MIC 128 ug/ml), S.aureus ATCC 43300 (MIC 128 ug/ml) [MRSA-inactive], and C. albicans ATCC 10231 (MIC 16 ug/ml). Antimicrobial activity was no
Evidence 8 Activity

Activity

MIC
Antifungal
16 µg/mL

Target

Candida albicans ATCC 10231

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

alis ATCC 29212 (MIC 128 ug/ml), S.aureus ATCC 43300 (MIC 128 ug/ml) [MRSA-inactive], and C. albicans ATCC 10231 (MIC 16 ug/ml). Antimicrobial activity was not enhanced by metals such as Zn2+ or Cu2+. In the case of E
Evidence 9 Activity

Activity

MIC
Antiparasitic
64 µg/mL

Target

Escherichia coli ATCC 25922

Source & Reference

DRAMP

Other

Source Activity Label Source Definition
Antiparasitic
DRAMP antiparasitic activity supported by activity records against parasitic targets.
e ref). More active than Clavanin A or B (see ref). Recent tests reveled activity against E. coli ATCC 25922 (MIC 64 ug/ml), E.faecalis ATCC 29212 (MIC 128 ug/ml), S.aureus ATCC 43300 (MIC 128 ug/ml) [MRSA-inactiv
Evidence 10 Activity

Activity

MIC
Antiparasitic
128 µg/mL

Target

Enterococcus faecalis ATCC 29212

Source & Reference

DRAMP

Other

or B (see ref). Recent tests reveled activity against E. coli ATCC 25922 (MIC 64 ug/ml), E.faecalis ATCC 29212 (MIC 128 ug/ml), S.aureus ATCC 43300 (MIC 128 ug/ml) [MRSA-inactive], and C. albicans ATCC 10231 (MIC 16
Evidence 11 Activity

Activity

MIC
Antiparasitic
128 µg/mL

Target

S.aureus ATCC 43300

Source & Reference

DRAMP

Other

ctivity against E. coli ATCC 25922 (MIC 64 ug/ml), E.faecalis ATCC 29212 (MIC 128 ug/ml), S.aureus ATCC 43300 (MIC 128 ug/ml) [MRSA-inactive], and C. albicans ATCC 10231 (MIC 16 ug/ml). Antimicrobial activity was no
Evidence 12 Activity

Activity

MIC
Antiparasitic
16 µg/mL

Target

Candida albicans ATCC 10231

Source & Reference

DRAMP

Other

alis ATCC 29212 (MIC 128 ug/ml), S.aureus ATCC 43300 (MIC 128 ug/ml) [MRSA-inactive], and C. albicans ATCC 10231 (MIC 16 ug/ml). Antimicrobial activity was not enhanced by metals such as Zn2+ or Cu2+. In the case of E
Evidence 13 Activity

Activity

0% Cell death
Toxicity
256 µg/mL
Cytotoxic
0% Cell death | 256 | µg/mL | target cell: Human renal proximal tubular epithelial cells (HRPTEC)

Target

Human renal proximal tubular epithelial cells (HRPTEC)

Source & Reference

NA
DBAASP
Chemical "Butterfly Effect" Explaining the Coordination Chemistry and Antimicrobial Properties of Clavanin Complexes. | Inorg Chem | 2021
Evidence 14 Activity

Activity

17% Cell death
Toxicity
256 µg/mL
Cytotoxic
17% Cell death | 256 | µg/mL | target cell: Human renal proximal tubular epithelial cells (HRPTEC)

Target

Human renal proximal tubular epithelial cells (HRPTEC)

Source & Reference

NA
DBAASP
Chemical "Butterfly Effect" Explaining the Coordination Chemistry and Antimicrobial Properties of Clavanin Complexes. | Inorg Chem | 2021
Evidence 15 Activity

Activity

22% Cell death
Toxicity
128 µg/mL
Cytotoxic
22% Cell death | 128 | µg/mL | target cell: Human renal proximal tubular epithelial cells (HRPTEC)

Target

Human renal proximal tubular epithelial cells (HRPTEC)

Source & Reference

NA
DBAASP
Chemical "Butterfly Effect" Explaining the Coordination Chemistry and Antimicrobial Properties of Clavanin Complexes. | Inorg Chem | 2021