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Peptide record

TPDB10231

RV-23 Antibacterial Anticancer Antifungal Antiparasitic Antiviral Hemolysis Toxicity standard
23 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB10231
RV-23
Antibacterial Anticancer Antifungal Antiparasitic Antiviral Hemolysis Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia AFP-GFuse Antifungipept CAFPdb APD_complete APD_hemolytic HemoPI Hemolytic2 PD_Hemolysis ToxinPred 3.0 DBAASP
standard
No
A 23-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
RIGVLLARLPKLFSLFKLMGKKV
Physicochemical Analysis
C126H219N33O25S1
NDCEQHTWY
L
2628.39
12.44
6
0
13
+6
-0.01
0.748
148.26
Mammalian: 1 hour Yeast: 2 min E.coli: 2 min
0
0.00
1
Residue Composition
number
1
A
2
R
0
N
0
D
0
C
0
E
0
Q
2
G
0
H
1
I
6
L
4
K
1
M
2
F
1
P
1
S
0
T
0
W
0
Y
2
V
Amino Acid Distribution
A: 1 R: 2 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 2 H: 0 I: 1 L: 6 K: 4 M: 1 F: 2 P: 1 S: 1 T: 0 W: 0 Y: 0 V: 2
Chemical Descriptors
23
C126H219N33O25S1
2628.39
12.44
+6
-0.01
0.748
Evidence Records 20 records
Evidence 1 Activity

Activity

MIC
Antibacterial
2.5 µM

Target

Escherichia coli

Source & Reference

dbAMP DRAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class. DRAMP antibacterial activity supported by MIC records against bacterial target organisms.
Active against E. coli (MIC 2.5 uM), K. pneumoniae ATCC 10031 (MIC 6.25 uM), S. aureus (MIC 40 uM) and C. albicans (MIC 80 uM
Evidence 2 Activity

Activity

MIC
Antibacterial
6.25 µM

Target

Klebsiella pneumoniae ATCC 10031

Source & Reference

dbAMP DRAMP

Other

Active against E. coli (MIC 2.5 uM), K. pneumoniae ATCC 10031 (MIC 6.25 uM), S. aureus (MIC 40 uM) and C. albicans (MIC 80 uM). Also inhibit bovine and caprine herpe
Evidence 3 Activity

Activity

MIC
Antibacterial
40 µM

Target

Staphylococcus aureus

Source & Reference

dbAMP DRAMP

Other

Active against E. coli (MIC 2.5 uM), K. pneumoniae ATCC 10031 (MIC 6.25 uM), S. aureus (MIC 40 uM) and C. albicans (MIC 80 uM). Also inhibit bovine and caprine herpesviruses, canine distem
Evidence 4 Activity

Activity

MIC
Antibacterial
80 µM

Target

Candida albicans

Source & Reference

dbAMP DRAMP

Other

t E. coli (MIC 2.5 uM), K. pneumoniae ATCC 10031 (MIC 6.25 uM), S. aureus (MIC 40 uM) and C. albicans (MIC 80 uM). Also inhibit bovine and caprine herpesviruses, canine distemper virus, bovine viral diar
Evidence 5 Activity

Activity

MIC
Antifungal
2.5 µM

Target

Escherichia coli

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class. DRAMP antifungal activity supported by activity records against fungal target organisms.
Active against E. coli (MIC 2.5 uM), K. pneumoniae ATCC 10031 (MIC 6.25 uM), S. aureus (MIC 40 uM) and C. albicans (MIC 80 uM
Evidence 6 Activity

Activity

MIC
Antifungal
6.25 µM

Target

Klebsiella pneumoniae ATCC 10031

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Active against E. coli (MIC 2.5 uM), K. pneumoniae ATCC 10031 (MIC 6.25 uM), S. aureus (MIC 40 uM) and C. albicans (MIC 80 uM). Also inhibit bovine and caprine herpe
Evidence 7 Activity

Activity

MIC
Antifungal
40 µM

Target

Staphylococcus aureus

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Active against E. coli (MIC 2.5 uM), K. pneumoniae ATCC 10031 (MIC 6.25 uM), S. aureus (MIC 40 uM) and C. albicans (MIC 80 uM). Also inhibit bovine and caprine herpesviruses, canine distem
Evidence 8 Activity

Activity

MIC
Antifungal
80 µM

Target

Candida albicans

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

t E. coli (MIC 2.5 uM), K. pneumoniae ATCC 10031 (MIC 6.25 uM), S. aureus (MIC 40 uM) and C. albicans (MIC 80 uM). Also inhibit bovine and caprine herpesviruses, canine distemper virus, bovine viral diar
Evidence 9 Activity

Activity

MIC
Antiparasitic
2.5 µM

Target

Escherichia coli

Source & Reference

DRAMP

Other

Source Activity Label Source Definition
Antiparasitic
DRAMP antiparasitic activity supported by activity records against parasitic targets.
Active against E. coli (MIC 2.5 uM), K. pneumoniae ATCC 10031 (MIC 6.25 uM), S. aureus (MIC 40 uM) and C. albicans (MIC 80 uM
Evidence 10 Activity

Activity

MIC
Antiparasitic
6.25 µM

Target

Klebsiella pneumoniae ATCC 10031

Source & Reference

DRAMP

Other

Active against E. coli (MIC 2.5 uM), K. pneumoniae ATCC 10031 (MIC 6.25 uM), S. aureus (MIC 40 uM) and C. albicans (MIC 80 uM). Also inhibit bovine and caprine herpe
Evidence 11 Activity

Activity

MIC
Antiparasitic
40 µM

Target

Staphylococcus aureus

Source & Reference

DRAMP

Other

Active against E. coli (MIC 2.5 uM), K. pneumoniae ATCC 10031 (MIC 6.25 uM), S. aureus (MIC 40 uM) and C. albicans (MIC 80 uM). Also inhibit bovine and caprine herpesviruses, canine distem
Evidence 12 Activity

Activity

MIC
Antiparasitic
80 µM

Target

Candida albicans

Source & Reference

DRAMP

Other

t E. coli (MIC 2.5 uM), K. pneumoniae ATCC 10031 (MIC 6.25 uM), S. aureus (MIC 40 uM) and C. albicans (MIC 80 uM). Also inhibit bovine and caprine herpesviruses, canine distemper virus, bovine viral diar
Evidence 13 Activity

Activity

MIC
Antiviral
2.5 µM

Target

Escherichia coli

Source & Reference

DRAMP

Other

Source Activity Label Source Definition
Antiviral
DRAMP antiviral activity supported by activity records against viral targets.
Active against E. coli (MIC 2.5 uM), K. pneumoniae ATCC 10031 (MIC 6.25 uM), S. aureus (MIC 40 uM) and C. albicans (MIC 80 uM
Evidence 14 Activity

Activity

MIC
Antiviral
6.25 µM

Target

Klebsiella pneumoniae ATCC 10031

Source & Reference

DRAMP

Other

Active against E. coli (MIC 2.5 uM), K. pneumoniae ATCC 10031 (MIC 6.25 uM), S. aureus (MIC 40 uM) and C. albicans (MIC 80 uM). Also inhibit bovine and caprine herpe
Evidence 15 Activity

Activity

MIC
Antiviral
40 µM

Target

Staphylococcus aureus

Source & Reference

DRAMP

Other

Active against E. coli (MIC 2.5 uM), K. pneumoniae ATCC 10031 (MIC 6.25 uM), S. aureus (MIC 40 uM) and C. albicans (MIC 80 uM). Also inhibit bovine and caprine herpesviruses, canine distem
Evidence 16 Activity

Activity

MIC
Antiviral
80 µM

Target

Candida albicans

Source & Reference

DRAMP

Other

t E. coli (MIC 2.5 uM), K. pneumoniae ATCC 10031 (MIC 6.25 uM), S. aureus (MIC 40 uM) and C. albicans (MIC 80 uM). Also inhibit bovine and caprine herpesviruses, canine distemper virus, bovine viral diar
Evidence 17 Activity

Activity

50% Hemolysis
Toxicity
35 µM
Hemolytic Cytotoxic
50% Hemolysis | 35 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Evidence 18 Activity

Activity

% Hemolysis
Toxicity
60 %
Hemolytic
Hemolytic_activity: [Ref.27271216] 60% hemolysis at 20 µM , 90% hemolysis at 40 µM , 100% hemolysis at 60 µM , 100% hemolysis at 100 µM against human red blood cells

Target

erythrocytes

Source & Reference

NA
DRAMP
Peptides. 2006 Jun 27(6):1305-1312.##Sci Rep. 2016 Jun 8 6:27394. doi: 10.1038/srep27394.
Evidence 19 Activity

Target

Cutibacterium acnes

Source & Reference

DBAASP
Evidence 20 Hemolysis

Source & Reference

APD_complete APD_hemolytic HemoPI PD_Hemolysis
APD_complete APD_hemolytic PD_Hemolysis

Other

Source Activity Label Source Definition
Hemolysis
APD_complete APD-derived hemolytic peptide annotation. APD_hemolytic APD hemolytic peptide annotation.