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Peptide record

TPDB10226

Antibacterial Anticancer Antifungal Antiparasitic Antiviral Toxicity standard
23 amino acids
Basic Information
3D PDB MODEL
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TPDB10226
Antibacterial Anticancer Antifungal Antiparasitic Antiviral Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia Antifungipept ToxinPred 3.0
standard
No
A 23-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
GLKDIFKAGLGSLVKGIAAHVAN
Physicochemical Analysis
C104H175N29O28
RCEQMPTWY
AG
2279.71
10.32
4
1
12
+2
1.78
0.630
127.39
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
0
0.00
2
Residue Composition
number
4
A
0
R
1
N
1
D
0
C
0
E
0
Q
4
G
1
H
2
I
3
L
3
K
0
M
1
F
0
P
1
S
0
T
0
W
0
Y
2
V
Amino Acid Distribution
A: 4 R: 0 N: 1 D: 1 C: 0 E: 0 Q: 0 G: 4 H: 1 I: 2 L: 3 K: 3 M: 0 F: 1 P: 0 S: 1 T: 0 W: 0 Y: 0 V: 2
Chemical Descriptors
23
C104H175N29O28
2279.71
10.32
+2
1.78
0.630
Evidence Records 7 records
Evidence 1 Activity

Activity

MIC
Antibacterial
25 µM

Target

Escherichia coli

Source & Reference

dbAMP DRAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class. DRAMP antibacterial activity supported by MIC records against bacterial target organisms.
Active against primarily G- bacteria such as E. coli (MIC 25 uM) and Salmonella strains.
Evidence 2 Activity

Activity

MIC
Antifungal
25 µM

Target

Escherichia coli

Source & Reference

dbAMP DRAMP Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class. DRAMP antifungal activity supported by activity records against fungal target organisms.
Active against primarily G- bacteria such as E. coli (MIC 25 uM) and Salmonella strains.
Evidence 3 Activity

Activity

MIC
Antiparasitic
25 µM

Target

Escherichia coli

Source & Reference

DRAMP

Other

Source Activity Label Source Definition
Antiparasitic
DRAMP antiparasitic activity supported by activity records against parasitic targets.
Active against primarily G- bacteria such as E. coli (MIC 25 uM) and Salmonella strains.
Evidence 4 Activity

Activity

MIC
Antiviral
25 µM

Target

Escherichia coli

Source & Reference

DRAMP

Other

Source Activity Label Source Definition
Antiviral
DRAMP antiviral activity supported by activity records against viral targets.
Active against primarily G- bacteria such as E. coli (MIC 25 uM) and Salmonella strains.
Evidence 5 Activity

Activity

50% Hemolysis
Toxicity
>100 µM
Hemolytic Cytotoxic
50% Hemolysis | >100 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
The alyteserins: two families of antimicrobial peptides from the skin secretions of the midwife toad Alytes obstetricans (Alytidae). | Peptides | 2009
Evidence 6 Activity

Activity

11% Hemolysis
Toxicity
100 µM
Hemolytic Cytotoxic
11% Hemolysis | 100 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
The alyteserins: two families of antimicrobial peptides from the skin secretions of the midwife toad Alytes obstetricans (Alytidae). | Peptides | 2009
Evidence 7 Activity

Activity

LC50
Toxicity
100 µM
Hemolytic
Hemolytic_activity: [Ref:19463738] LC50 > 100 µM against human erthrocytes. Alyteserin-1a induced a hemolysis of 11% at the concentration of 100 µM.

Target

erythrocytes

Source & Reference

NA
DRAMP
Peptides. 2009 Jun 30(6):1069-1073.