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Peptide record

TPDB10224

Antibacterial Anticancer Antifungal Antiparasitic Hemolysis Toxicity standard
23 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB10224
Antibacterial Anticancer Antifungal Antiparasitic Hemolysis Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 dbAMP Peptipedia ACP740 _ACP240 AntiCP 2.0 CancerPPD 2.0 SATPdb dbACP iACP-DRLF pep-lab AFP-GFuse Antifungipept CAFPdb i2APP HemoPI Hemolytic2 PD_Hemolysis
standard
No
A 23-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, Peptipedia, and other sources, with an available 3D structural model.
Sequence
GIGKFLHAAKKFAKAFVAEIMNS
Physicochemical Analysis
C116H184N30O28S1
RDCQPTWY
A
2478.98
10.55
5
1
13
+3
1.93
0.387
85.22
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
0
0.00
2
Residue Composition
number
5
A
0
R
1
N
0
D
0
C
1
E
0
Q
2
G
1
H
2
I
1
L
4
K
1
M
3
F
0
P
1
S
0
T
0
W
0
Y
1
V
Amino Acid Distribution
A: 5 R: 0 N: 1 D: 0 C: 0 E: 1 Q: 0 G: 2 H: 1 I: 2 L: 1 K: 4 M: 1 F: 3 P: 0 S: 1 T: 0 W: 0 Y: 0 V: 1
Chemical Descriptors
23
C116H184N30O28S1
2478.98
10.55
+3
1.93
0.387
Evidence Records 25 records
Evidence 1 Activity

Activity

MIC
Antibacterial
10 µM

Target

C. parasitica

Source & Reference

dbAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class.
Active against fungi C. parasitica (MIC 10 uM), F. oxysporum (MIC 15 uM), and S. musiva (MIC 5 uM), plant pathogenic bacteria A. tumefac
Evidence 2 Activity

Activity

MIC
Antibacterial
15 µM

Target

F. oxysporum

Source & Reference

dbAMP

Other

Active against fungi C. parasitica (MIC 10 uM), F. oxysporum (MIC 15 uM), and S. musiva (MIC 5 uM), plant pathogenic bacteria A. tumefaciens (MIC 100 uM), E.amylo
Evidence 3 Activity

Activity

MIC
Antibacterial
5 µM

Target

S. musiva

Source & Reference

dbAMP

Other

Active against fungi C. parasitica (MIC 10 uM), F. oxysporum (MIC 15 uM), and S. musiva (MIC 5 uM), plant pathogenic bacteria A. tumefaciens (MIC 100 uM), E.amylovora (MIC 250 uM), and P.s
Evidence 4 Activity

Activity

MIC
Antibacterial
100 µM

Target

A. tumefaciens

Source & Reference

dbAMP

Other

MIC 10 uM), F. oxysporum (MIC 15 uM), and S. musiva (MIC 5 uM), plant pathogenic bacteria A. tumefaciens (MIC 100 uM), E.amylovora (MIC 250 uM), and P.syringae (MIC 250 uM).
Evidence 5 Activity

Activity

MIC
Antibacterial
250 µM

Target

E.amylovora

Source & Reference

dbAMP

Other

15 uM), and S. musiva (MIC 5 uM), plant pathogenic bacteria A. tumefaciens (MIC 100 uM), E.amylovora (MIC 250 uM), and P.syringae (MIC 250 uM).
Evidence 6 Activity

Activity

MIC
Antibacterial
250 µM

Target

P.syringae

Source & Reference

dbAMP

Other

uM), plant pathogenic bacteria A. tumefaciens (MIC 100 uM), E.amylovora (MIC 250 uM), and P.syringae (MIC 250 uM).
Evidence 7 Activity

Activity

MIC
Antifungal
10 µM

Target

C. parasitica

Source & Reference

dbAMP CAFPdb Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class.
Active against fungi C. parasitica (MIC 10 uM), F. oxysporum (MIC 15 uM), and S. musiva (MIC 5 uM), plant pathogenic bacteria A. tumefac
Evidence 8 Activity

Activity

MIC
Antifungal
15 µM

Target

F. oxysporum

Source & Reference

dbAMP CAFPdb Antifungipept

Other

Active against fungi C. parasitica (MIC 10 uM), F. oxysporum (MIC 15 uM), and S. musiva (MIC 5 uM), plant pathogenic bacteria A. tumefaciens (MIC 100 uM), E.amylo
Evidence 9 Activity

Activity

MIC
Antifungal
5 µM

Target

S. musiva

Source & Reference

dbAMP CAFPdb Antifungipept

Other

Active against fungi C. parasitica (MIC 10 uM), F. oxysporum (MIC 15 uM), and S. musiva (MIC 5 uM), plant pathogenic bacteria A. tumefaciens (MIC 100 uM), E.amylovora (MIC 250 uM), and P.s
Evidence 10 Activity

Activity

MIC
Antifungal
100 µM

Target

A. tumefaciens

Source & Reference

dbAMP CAFPdb Antifungipept

Other

MIC 10 uM), F. oxysporum (MIC 15 uM), and S. musiva (MIC 5 uM), plant pathogenic bacteria A. tumefaciens (MIC 100 uM), E.amylovora (MIC 250 uM), and P.syringae (MIC 250 uM).
Evidence 11 Activity

Activity

MIC
Antifungal
250 µM

Target

E.amylovora

Source & Reference

dbAMP CAFPdb Antifungipept

Other

15 uM), and S. musiva (MIC 5 uM), plant pathogenic bacteria A. tumefaciens (MIC 100 uM), E.amylovora (MIC 250 uM), and P.syringae (MIC 250 uM).
Evidence 12 Activity

Activity

MIC
Antifungal
250 µM

Target

P.syringae

Source & Reference

dbAMP CAFPdb Antifungipept

Other

uM), plant pathogenic bacteria A. tumefaciens (MIC 100 uM), E.amylovora (MIC 250 uM), and P.syringae (MIC 250 uM).
Evidence 13 Activity

Activity

MIC
Antiparasitic
10 µM

Target

C. parasitica

Source & Reference

NA

Other

Active against fungi C. parasitica (MIC 10 uM), F. oxysporum (MIC 15 uM), and S. musiva (MIC 5 uM), plant pathogenic bacteria A. tumefac
Evidence 14 Activity

Activity

MIC
Antiparasitic
15 µM

Target

F. oxysporum

Source & Reference

NA

Other

Active against fungi C. parasitica (MIC 10 uM), F. oxysporum (MIC 15 uM), and S. musiva (MIC 5 uM), plant pathogenic bacteria A. tumefaciens (MIC 100 uM), E.amylo
Evidence 15 Activity

Activity

MIC
Antiparasitic
5 µM

Target

S. musiva

Source & Reference

NA

Other

Active against fungi C. parasitica (MIC 10 uM), F. oxysporum (MIC 15 uM), and S. musiva (MIC 5 uM), plant pathogenic bacteria A. tumefaciens (MIC 100 uM), E.amylovora (MIC 250 uM), and P.s
Evidence 16 Activity

Activity

MIC
Antiparasitic
100 µM

Target

A. tumefaciens

Source & Reference

NA

Other

MIC 10 uM), F. oxysporum (MIC 15 uM), and S. musiva (MIC 5 uM), plant pathogenic bacteria A. tumefaciens (MIC 100 uM), E.amylovora (MIC 250 uM), and P.syringae (MIC 250 uM).
Evidence 17 Activity

Activity

MIC
Antiparasitic
250 µM

Target

E.amylovora

Source & Reference

NA

Other

15 uM), and S. musiva (MIC 5 uM), plant pathogenic bacteria A. tumefaciens (MIC 100 uM), E.amylovora (MIC 250 uM), and P.syringae (MIC 250 uM).
Evidence 18 Activity

Activity

MIC
Antiparasitic
250 µM

Target

P.syringae

Source & Reference

NA

Other

uM), plant pathogenic bacteria A. tumefaciens (MIC 100 uM), E.amylovora (MIC 250 uM), and P.syringae (MIC 250 uM).
Evidence 19 Activity

Activity

35% Hemolysis
Toxicity
200 µM
Hemolytic Cytotoxic
35% Hemolysis | 200 | µM | target cell: Rabbit erythrocytes

Target

Rabbit erythrocytes

Source & Reference

NA
DBAASP
Lycotoxins, antimicrobial peptides from venom of the wolf spider Lycosa carolinensis. | J Biol Chem | 1998
Evidence 20 Activity

Activity

0% Hemolysis
Toxicity
50 µg/mL
Hemolytic Cytotoxic
0% Hemolysis | 50 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Evidence for phenylalanine zipper-mediated dimerization in the X-ray crystal structure of a magainin 2 analogue. | J Am Chem Soc | 2013
Evidence 21 Activity

Activity

10% Hemolysis
Toxicity
100 µg/mL
Hemolytic Cytotoxic
10% Hemolysis | 100 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Evidence for phenylalanine zipper-mediated dimerization in the X-ray crystal structure of a magainin 2 analogue. | J Am Chem Soc | 2013
Evidence 22 Activity

Activity

50% Hemolysis
Toxicity
9.6±0.9 µM
Hemolytic Cytotoxic
50% Hemolysis | 9.6±0.9 | µM | target cell: Sheep erythrocytes

Target

Sheep erythrocytes

Source & Reference

NA
DBAASP
A Rapid and Quantitative Flow Cytometry Method for the Analysis of Membrane Disruptive Antimicrobial Activity. | PLoS One | 2016
Evidence 23 Activity

Activity

50% Hemolysis
Toxicity
175 µg/mL
Hemolytic Cytotoxic
50% Hemolysis | 175 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Antimicrobial activity and protease stability of peptides containing fluorinated amino acids | J Am Chem Soc | 2007
Evidence 24 Activity

Activity

68% Hemolysis
Toxicity
100 µM
Hemolytic Cytotoxic
68% Hemolysis | 100 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Potent antimicrobial peptides with selectivity for Bacillus anthracis over human erythrocytes. | Int J Antimicrob Agents | 2011
Evidence 25 Hemolysis

Source & Reference

HemoPI PD_Hemolysis
PD_Hemolysis