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Peptide record

TPDB10223

Antibacterial Anticancer Antifungal Antiparasitic Antiviral standard
23 amino acids
Basic Information
3D PDB MODEL
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TPDB10223
Antibacterial Anticancer Antifungal Antiparasitic Antiviral
Anti-infective peptides Cancer-related peptides
AntiBP3 dbAMP DRAMP Peptipedia Antifungipept CAFPdb
standard
No
A 23-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
LLGDFFRKSKEKIGKEFKRIVQR
Physicochemical Analysis
C130H216N38O32
ANCHMPTWY
K
2823.38
11.06
8
3
8
+5
8.32
-0.843
80.43
Mammalian: 5.5 hour Yeast: 3 min E.coli: 2 min
0
0.00
2
Residue Composition
number
0
A
3
R
0
N
1
D
0
C
2
E
1
Q
2
G
0
H
2
I
2
L
5
K
0
M
3
F
0
P
1
S
0
T
0
W
0
Y
1
V
Amino Acid Distribution
A: 0 R: 3 N: 0 D: 1 C: 0 E: 2 Q: 1 G: 2 H: 0 I: 2 L: 2 K: 5 M: 0 F: 3 P: 0 S: 1 T: 0 W: 0 Y: 0 V: 1
Chemical Descriptors
23
C130H216N38O32
2823.38
11.06
+5
8.32
-0.843
Evidence Records 8 records
Evidence 1 Activity

Activity

MIC
Antibacterial
9 µM

Target

Escherichia coli DC2 with altered outer membrane

Source & Reference

dbAMP DRAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class. DRAMP antibacterial activity supported by MIC records against bacterial target organisms.
Active against only susceptible bacterial S. aureus mprF (KO) (diffusion assay), E. coli DC2 with altered outer membrane (MIC 9 uM) but weakly against E.coli K12 (MIC 160 uM). Based on the 3D structure, however, a mutatio
Evidence 2 Activity

Activity

MIC
Antibacterial
160 µM

Target

E.coli K12

Source & Reference

dbAMP DRAMP

Other

(diffusion assay), E. coli DC2 with altered outer membrane (MIC 9 uM) but weakly against E.coli K12 (MIC 160 uM). Based on the 3D structure, however, a mutation of Ser9 with either Ala or Val modulates
Evidence 3 Activity

Activity

MIC
Antifungal
9 µM

Target

Escherichia coli DC2 with altered outer membrane

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class. DRAMP antifungal activity supported by activity records against fungal target organisms.
Active against only susceptible bacterial S. aureus mprF (KO) (diffusion assay), E. coli DC2 with altered outer membrane (MIC 9 uM) but weakly against E.coli K12 (MIC 160 uM). Based on the 3D structure, however, a mutatio
Evidence 4 Activity

Activity

MIC
Antifungal
160 µM

Target

E.coli K12

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

(diffusion assay), E. coli DC2 with altered outer membrane (MIC 9 uM) but weakly against E.coli K12 (MIC 160 uM). Based on the 3D structure, however, a mutation of Ser9 with either Ala or Val modulates
Evidence 5 Activity

Activity

MIC
Antiparasitic
9 µM

Target

Escherichia coli DC2 with altered outer membrane

Source & Reference

DRAMP

Other

Source Activity Label Source Definition
Antiparasitic
DRAMP antiparasitic activity supported by activity records against parasitic targets.
Active against only susceptible bacterial S. aureus mprF (KO) (diffusion assay), E. coli DC2 with altered outer membrane (MIC 9 uM) but weakly against E.coli K12 (MIC 160 uM). Based on the 3D structure, however, a mutatio
Evidence 6 Activity

Activity

MIC
Antiparasitic
160 µM

Target

E.coli K12

Source & Reference

DRAMP

Other

(diffusion assay), E. coli DC2 with altered outer membrane (MIC 9 uM) but weakly against E.coli K12 (MIC 160 uM). Based on the 3D structure, however, a mutation of Ser9 with either Ala or Val modulates
Evidence 7 Activity

Activity

MIC
Antiviral
9 µM

Target

Escherichia coli DC2 with altered outer membrane

Source & Reference

DRAMP

Other

Source Activity Label Source Definition
Antiviral
DRAMP antiviral activity supported by activity records against viral targets.
Active against only susceptible bacterial S. aureus mprF (KO) (diffusion assay), E. coli DC2 with altered outer membrane (MIC 9 uM) but weakly against E.coli K12 (MIC 160 uM). Based on the 3D structure, however, a mutatio
Evidence 8 Activity

Activity

MIC
Antiviral
160 µM

Target

E.coli K12

Source & Reference

DRAMP

Other

(diffusion assay), E. coli DC2 with altered outer membrane (MIC 9 uM) but weakly against E.coli K12 (MIC 160 uM). Based on the 3D structure, however, a mutation of Ser9 with either Ala or Val modulates