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Peptide record

TPDB10221

Antibacterial Anticancer Antifungal Antiparasitic Antiviral Hemolysis Toxicity standard
23 amino acids
Basic Information
3D PDB MODEL
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TPDB10221
Antibacterial Anticancer Antifungal Antiparasitic Antiviral Hemolysis Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia Antifungipept CAFPdb APD_complete APD_hemolytic Hemolytic2 PD_Hemolysis
standard
No
A 23-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
GVVTDLLKTAGKLLGNLVGSLSG
Physicochemical Analysis
C98H174N26O31
RCEQHIMFPWY
L
2212.61
9.88
2
1
10
+1
0.90
0.757
143.91
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
0
0.00
5
Residue Composition
number
1
A
0
R
1
N
1
D
0
C
0
E
0
Q
5
G
0
H
0
I
6
L
2
K
0
M
0
F
0
P
2
S
2
T
0
W
0
Y
3
V
Amino Acid Distribution
A: 1 R: 0 N: 1 D: 1 C: 0 E: 0 Q: 0 G: 5 H: 0 I: 0 L: 6 K: 2 M: 0 F: 0 P: 0 S: 2 T: 2 W: 0 Y: 0 V: 3
Chemical Descriptors
23
C98H174N26O31
2212.61
9.88
+1
0.90
0.757
Evidence Records 5 records
Evidence 1 Activity

Activity

% Hemolysis
Hemolysis
35 71 %
[Ref.17128968]35% hemolytic at 50 µM, 71% hemolytic activity at 100 µM against rat red blood cells

Target

rat red blood cells

Source & Reference

Hemolytik APD_complete APD_hemolytic PD_Hemolysis
DRAMP4
Biochemistry 2006 45: 14285-14297.

Other

Source Activity Label Source Definition
Hemolysis
APD_complete APD-derived hemolytic peptide annotation. APD_hemolytic APD hemolytic peptide annotation. Hemolytik experimentally validated hemolytic peptide annotation.
Evidence 2 Activity

Activity

35% Hemolysis
Toxicity
50 µM
Hemolytic Cytotoxic
35% Hemolysis | 50 | µM | target cell: Rat erythrocytes

Target

Rat erythrocytes

Source & Reference

NA
DBAASP
The plasticins: membrane adsorption, lipid disorders, and biological activity. | Biochemistry | 2006
Evidence 3 Activity

Activity

71% Hemolysis
Toxicity
100 µM
Hemolytic Cytotoxic
71% Hemolysis | 100 | µM | target cell: Rat erythrocytes

Target

Rat erythrocytes

Source & Reference

NA
DBAASP
The plasticins: membrane adsorption, lipid disorders, and biological activity. | Biochemistry | 2006
Evidence 4 Activity

Activity

Toxicity
Hemolytic
Hemolytic_activity: [Ref.17128968]35% hemolytic at 50 µM, 71% hemolytic activity at 100 µM against rat red blood cells

Target

erythrocytes

Source & Reference

NA
DRAMP
Biochemistry 2006 45: 14285-14297.
Evidence 5 Hemolysis

Activity

35 71 %
% Hemolysis
[Ref.17128968]35% hemolytic at 50 µM, 71% hemolytic activity at 100 µM against rat red blood cells
Hemolysis

Target

rat red blood cells

Source & Reference

APD_complete APD_hemolytic PD_Hemolysis
Biochemistry 2006 45: 14285-14297.
DRAMP4
APD_complete APD_hemolytic PD_Hemolysis

Other

Source Activity Label Source Definition
Hemolysis
APD_complete APD-derived hemolytic peptide annotation. APD_hemolytic APD hemolytic peptide annotation.