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Peptide record

TPDB10220

Antibacterial Anticancer Antifungal Antiparasitic Toxicity standard

23 amino acids

3D PDB MODEL

Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.

TPDB ID TPDB10220

Activity

Antibacterial Anticancer Antifungal Antiparasitic Toxicity

Activity_category_statistics

Anti-infective peptides Cancer-related peptides Toxicity and safety peptides

Database_Source

AntiBP3 dbAMP DRAMP Peptipedia ACP740 _ACP240 Antifungipept CAFPdb ToxinPred 3.0

Sequence_Type

standard

Has_Modification No

Description A 23-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.

Sequence

GLLRASSVWGRKYYVDLAGCAKA

FASTA

>TPDB10220|Antibacterial;Anticancer;Antifungal;Antiparasitic;Toxicity|length=23
GLLRASSVWGRKYYVDLAGCAKA

Formula C112H178N32O30S1

Absent Amino Acids NEQHIMFPT

Common Amino Acids A

Mass 2484.90

PI 9.98

Basic Residues 4

Acidic Residues 1

Hydrophobic Residues 12

Net Charge +3

Boman Index -1.07

Hydrophobicity 0.126

Aliphatic Index 93.48

Half Life

Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour

Extinction Coefficient Cystines 8480

Absorbance 280nm 341.26

Polar Residues 5

number

Amino Acid Distribution

A: 4 R: 2 N: 0 D: 1 C: 1 E: 0 Q: 0 G: 3 H: 0 I: 0 L: 3 K: 2 M: 0 F: 0 P: 0 S: 2 T: 0 W: 1 Y: 2 V: 2

Length

Formula

C112H178N32O30S1

Mass

2484.90

9.98

Net Charge

Boman Index

-1.07

Hydrophobicity

0.126

Evidence 1 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 20 µg/mL

Target

Target Organism H. pylori NCTC11637

Source & Reference

Database Source dbAMP DRAMP

Other

Source Activity Label	Source Definition
Antibacterial	dbAMP classified as Antibacterial under the Anti-bacterial function class. DRAMP antibacterial activity supported by MIC records against bacterial target organisms.

Evidence Text

Active against H. pylori NCTC11637 (MIC 20 ug/ml), S. aureus ATCC2592 (MIC 5 ug/ml), E. coli ATCC25922 (MIC 30 ug/ml), B. dysenteriae (MIC

Evidence 2 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 5 µg/mL

Target

Target Organism Staphylococcus aureus ATCC2592

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

Active against H. pylori NCTC11637 (MIC 20 ug/ml), S. aureus ATCC2592 (MIC 5 ug/ml), E. coli ATCC25922 (MIC 30 ug/ml), B. dysenteriae (MIC 30 ug/ml), and C. albicans ATCC200

Evidence 3 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 30 µg/mL

Target

Target Organism Escherichia coli ATCC25922

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

Active against H. pylori NCTC11637 (MIC 20 ug/ml), S. aureus ATCC2592 (MIC 5 ug/ml), E. coli ATCC25922 (MIC 30 ug/ml), B. dysenteriae (MIC 30 ug/ml), and C. albicans ATCC2002 (25 ug/ml). Updated 4/2014.

Evidence 4 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 30 µg/mL

Target

Target Organism B. dysenteriae

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

11637 (MIC 20 ug/ml), S. aureus ATCC2592 (MIC 5 ug/ml), E. coli ATCC25922 (MIC 30 ug/ml), B. dysenteriae (MIC 30 ug/ml), and C. albicans ATCC2002 (25 ug/ml). Updated 4/2014.

Evidence 5 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 20 µg/mL

Target

Target Organism H. pylori NCTC11637

Source & Reference

Database Source dbAMP DRAMP CAFPdb Antifungipept

Other

Source Activity Label	Source Definition
Antifungal	dbAMP classified under the Anti-fungal function class. DRAMP antifungal activity supported by activity records against fungal target organisms.

Evidence Text

Active against H. pylori NCTC11637 (MIC 20 ug/ml), S. aureus ATCC2592 (MIC 5 ug/ml), E. coli ATCC25922 (MIC 30 ug/ml), B. dysenteriae (MIC

Evidence 6 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 5 µg/mL

Target

Target Organism Staphylococcus aureus ATCC2592

Source & Reference

Database Source dbAMP DRAMP CAFPdb Antifungipept

Other

Evidence Text

Active against H. pylori NCTC11637 (MIC 20 ug/ml), S. aureus ATCC2592 (MIC 5 ug/ml), E. coli ATCC25922 (MIC 30 ug/ml), B. dysenteriae (MIC 30 ug/ml), and C. albicans ATCC200

Evidence 7 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 30 µg/mL

Target

Target Organism Escherichia coli ATCC25922

Source & Reference

Database Source dbAMP DRAMP CAFPdb Antifungipept

Other

Evidence Text

Evidence 8 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 30 µg/mL

Target

Target Organism B. dysenteriae

Source & Reference

Database Source dbAMP DRAMP CAFPdb Antifungipept

Other

Evidence Text

11637 (MIC 20 ug/ml), S. aureus ATCC2592 (MIC 5 ug/ml), E. coli ATCC25922 (MIC 30 ug/ml), B. dysenteriae (MIC 30 ug/ml), and C. albicans ATCC2002 (25 ug/ml). Updated 4/2014.

Evidence 9 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 20 µg/mL

Target

Target Organism H. pylori NCTC11637

Source & Reference

Database Source DRAMP

Other

Source Activity Label	Source Definition
Antiparasitic	DRAMP antiparasitic activity supported by activity records against parasitic targets.

Evidence Text

Active against H. pylori NCTC11637 (MIC 20 ug/ml), S. aureus ATCC2592 (MIC 5 ug/ml), E. coli ATCC25922 (MIC 30 ug/ml), B. dysenteriae (MIC

Evidence 10 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 5 µg/mL

Target

Target Organism Staphylococcus aureus ATCC2592

Source & Reference

Database Source DRAMP

Other

Evidence Text

Active against H. pylori NCTC11637 (MIC 20 ug/ml), S. aureus ATCC2592 (MIC 5 ug/ml), E. coli ATCC25922 (MIC 30 ug/ml), B. dysenteriae (MIC 30 ug/ml), and C. albicans ATCC200

Evidence 11 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 30 µg/mL

Target

Target Organism Escherichia coli ATCC25922

Source & Reference

Database Source DRAMP

Other

Evidence Text

Evidence 12 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 30 µg/mL

Target

Target Organism B. dysenteriae

Source & Reference

Database Source DRAMP

Other

Evidence Text

11637 (MIC 20 ug/ml), S. aureus ATCC2592 (MIC 5 ug/ml), E. coli ATCC25922 (MIC 30 ug/ml), B. dysenteriae (MIC 30 ug/ml), and C. albicans ATCC2002 (25 ug/ml). Updated 4/2014.

Evidence 13 Activity

Activity

Activity Endpoint <5% Hemolysis

Detail Source Activity Toxicity

Activity Measurement 100 µg/mL

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

<5% Hemolysis | 100 | µg/mL | target cell: Rabbit erythrocytes

Target

Target Cell Rabbit erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Reference

An antimicrobial peptide with antimicrobial activity against Helicobacter pylori. | Peptides | 2007

Evidence 14 Activity

Activity

Activity Endpoint 50% Hemolysis

Detail Source Activity Toxicity

Activity Measurement 500 µM

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

50% Hemolysis | 500 | µM | target cell: Human erythrocytes

Target

Target Cell Human erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Selection and redesign for high selectivity of membrane-active antimicrobial peptides from a dedicated sequence/function database. | Biochim Biophys Acta | 2019