Back to search

Peptide record

TPDB10219

Antibacterial Anticancer Antifungal Antiparasitic Hemolysis Toxicity standard
23 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB10219
Antibacterial Anticancer Antifungal Antiparasitic Hemolysis Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia ACP740 _ACP240 AntiCP 2.0 iACP-DRLF Antifungipept CAFPdb APD_complete APD_hemolytic HemoPI Hemolytic2 PD_Hemolysis ToxinPred 3.0
standard
No
A 23-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
FLRFIGSVIHGIGHLVHHIGVAL
Physicochemical Analysis
C119H186N34O25
NDCEQKMPTWY
GHI
2493.00
11.05
5
0
13
+1
-0.32
1.291
160.87
Mammalian: 1.1 hour Yeast: 3 min E.coli: 2 min
0
0.00
1
Residue Composition
number
1
A
1
R
0
N
0
D
0
C
0
E
0
Q
4
G
4
H
4
I
3
L
0
K
0
M
2
F
0
P
1
S
0
T
0
W
0
Y
3
V
Amino Acid Distribution
A: 1 R: 1 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 4 H: 4 I: 4 L: 3 K: 0 M: 0 F: 2 P: 0 S: 1 T: 0 W: 0 Y: 0 V: 3
Chemical Descriptors
23
C119H186N34O25
2493.00
11.05
+1
-0.32
1.291
Evidence Records 8 records
Evidence 1 Activity

Activity

Hemolysis
[Ref.12005415]has potent hemolytic activity

Source & Reference

Hemolytik APD_complete APD_hemolytic PD_Hemolysis
DRAMP4
J Pept Res. 2001 Dec 58(6):445-456.

Other

Source Activity Label Source Definition
Hemolysis
APD_complete APD-derived hemolytic peptide annotation. APD_hemolytic APD hemolytic peptide annotation. Hemolytik experimentally validated hemolytic peptide annotation.
Evidence 2 Activity

Activity

75% Hemolysis
Toxicity
40 µg/mL
Hemolytic Cytotoxic
75% Hemolysis | 40 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Clavaspirin, an antibacterial and haemolytic peptide from Styela clava. | J Pept Res | 2001
Evidence 3 Activity

Activity

60% Hemolysis
Toxicity
40 µg/mL
Hemolytic Cytotoxic
60% Hemolysis | 40 | µg/mL | target cell: Bovine erythrocytes

Target

Bovine erythrocytes

Source & Reference

NA
DBAASP
Clavaspirin, an antibacterial and haemolytic peptide from Styela clava. | J Pept Res | 2001
Evidence 4 Activity

Activity

10% Hemolysis
Toxicity
37 µM
Hemolytic Cytotoxic
10% Hemolysis | 37 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
New antimicrobial peptide kills drug-resistant pathogens without detectable resistance | Oncotarget | 2018
Evidence 5 Activity

Activity

50% Hemolysis
Toxicity
64 µM
Hemolytic Cytotoxic
50% Hemolysis | 64 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
New antimicrobial peptide kills drug-resistant pathogens without detectable resistance | Oncotarget | 2018
Evidence 6 Activity

Activity

EC50
Toxicity
247 µM
Cytotoxic
EC50 | 247 | µM | target cell: Human keratinocytes HaCat

Target

Human keratinocytes HaCat

Source & Reference

NA
DBAASP
New antimicrobial peptide kills drug-resistant pathogens without detectable resistance | Oncotarget | 2018
Evidence 7 Activity

Activity

Toxicity
Hemolytic
Hemolytic_activity: [Ref.12005415]has potent hemolytic activity

Target

erythrocytes

Source & Reference

NA
DRAMP
J Pept Res. 2001 Dec 58(6):445-456.
Evidence 8 Hemolysis

Activity

[Ref.12005415]has potent hemolytic activity
Hemolysis

Source & Reference

APD_complete APD_hemolytic HemoPI PD_Hemolysis
J Pept Res. 2001 Dec 58(6):445-456.
DRAMP4
APD_complete APD_hemolytic PD_Hemolysis

Other

Source Activity Label Source Definition
Hemolysis
APD_complete APD-derived hemolytic peptide annotation. APD_hemolytic APD hemolytic peptide annotation.