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Peptide record

TPDB10218

Prepromelittin-related peptide Antibacterial Anticancer Antifungal Antiparasitic Antiviral Hemolysis Toxicity standard
23 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB10218
Prepromelittin-related peptide
Antibacterial Anticancer Antifungal Antiparasitic Antiviral Hemolysis Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia ACP740 _ACP240 AntiCP 2.0 CancerPPD 2.0 SATPdb dbACP iACP-DRLF pep-lab Antifungipept CAFPdb DRAVP 2.0 APD_complete APD_hemolytic Hemolytic2 PD_Hemolysis ToxinPred 3.0
standard
No
A 23-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
AIGSILGALAKGLPTLISWIKNR
Physicochemical Analysis
C111H190N30O28
DCEQHMFYV
IL
2392.91
11.64
3
0
12
+3
-1.75
0.730
148.70
Mammalian: 4.4 hour Yeast: >20 hour E.coli: >10 hour
5500
229.85
4
Residue Composition
number
3
A
1
R
1
N
0
D
0
C
0
E
0
Q
3
G
0
H
4
I
4
L
2
K
0
M
0
F
1
P
2
S
1
T
1
W
0
Y
0
V
Amino Acid Distribution
A: 3 R: 1 N: 1 D: 0 C: 0 E: 0 Q: 0 G: 3 H: 0 I: 4 L: 4 K: 2 M: 0 F: 0 P: 1 S: 2 T: 1 W: 1 Y: 0 V: 0
Chemical Descriptors
23
C111H190N30O28
2392.91
11.64
+3
-1.75
0.730
Free
L
Not Available
Free
Antibacterial
Rana tagoi [Tago frog]
Evidence Records 22 records
Evidence 1 Activity

Activity

MIC
Antibacterial
3.5 µM

Target

Staphylococcus aureus

Source & Reference

dbAMP DRAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class. DRAMP antibacterial activity supported by MIC records against bacterial target organisms.
Active against S. aureus (MIC 3.5 uM), E. coli (MIC 20-25 uM), K. pneumoniae ATCC 10031 (MIC 6.25 uM), and C. albicans (MIC 19
Evidence 2 Activity

Activity

MIC
Antibacterial
20-25 µM

Target

Escherichia coli

Source & Reference

dbAMP DRAMP

Other

Active against S. aureus (MIC 3.5 uM), E. coli (MIC 20-25 uM), K. pneumoniae ATCC 10031 (MIC 6.25 uM), and C. albicans (MIC 19 uM). Virus: AR-23 exhibi
Evidence 3 Activity

Activity

MIC
Antibacterial
6.25 µM

Target

Klebsiella pneumoniae ATCC 10031

Source & Reference

dbAMP DRAMP

Other

Active against S. aureus (MIC 3.5 uM), E. coli (MIC 20-25 uM), K. pneumoniae ATCC 10031 (MIC 6.25 uM), and C. albicans (MIC 19 uM). Virus: AR-23 exhibited a greater inhibitory activity in the
Evidence 4 Activity

Activity

MIC
Antibacterial
19 µM

Target

Candida albicans

Source & Reference

dbAMP DRAMP

Other

aureus (MIC 3.5 uM), E. coli (MIC 20-25 uM), K. pneumoniae ATCC 10031 (MIC 6.25 uM), and C. albicans (MIC 19 uM). Virus: AR-23 exhibited a greater inhibitory activity in the early stages of infection ag
Evidence 5 Activity

Activity

Not Available
Anticancer

Target

Fibrosarcoma
Not Available
Fibrous connective tissue

Assay & Model

Not Available
Not Available

Source & Reference

CancerPPD 2.0 dbACP SATPdb
CancerPPD2
2003

Other

Source Activity Label Source Definition
Anticancer
CancerPPD 2.0 manually curated experimentally verified anticancer peptide/protein annotation.
Evidence 6 Activity

Activity

MIC
Antifungal
3.5 µM

Target

Staphylococcus aureus

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class. DRAMP antifungal activity supported by activity records against fungal target organisms.
Active against S. aureus (MIC 3.5 uM), E. coli (MIC 20-25 uM), K. pneumoniae ATCC 10031 (MIC 6.25 uM), and C. albicans (MIC 19
Evidence 7 Activity

Activity

MIC
Antifungal
20-25 µM

Target

Escherichia coli

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Active against S. aureus (MIC 3.5 uM), E. coli (MIC 20-25 uM), K. pneumoniae ATCC 10031 (MIC 6.25 uM), and C. albicans (MIC 19 uM). Virus: AR-23 exhibi
Evidence 8 Activity

Activity

MIC
Antifungal
6.25 µM

Target

Klebsiella pneumoniae ATCC 10031

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Active against S. aureus (MIC 3.5 uM), E. coli (MIC 20-25 uM), K. pneumoniae ATCC 10031 (MIC 6.25 uM), and C. albicans (MIC 19 uM). Virus: AR-23 exhibited a greater inhibitory activity in the
Evidence 9 Activity

Activity

MIC
Antifungal
19 µM

Target

Candida albicans

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

aureus (MIC 3.5 uM), E. coli (MIC 20-25 uM), K. pneumoniae ATCC 10031 (MIC 6.25 uM), and C. albicans (MIC 19 uM). Virus: AR-23 exhibited a greater inhibitory activity in the early stages of infection ag
Evidence 10 Activity

Activity

MIC
Antiparasitic
3.5 µM

Target

Staphylococcus aureus

Source & Reference

DRAMP

Other

Source Activity Label Source Definition
Antiparasitic
DRAMP antiparasitic activity supported by activity records against parasitic targets.
Active against S. aureus (MIC 3.5 uM), E. coli (MIC 20-25 uM), K. pneumoniae ATCC 10031 (MIC 6.25 uM), and C. albicans (MIC 19
Evidence 11 Activity

Activity

MIC
Antiparasitic
20-25 µM

Target

Escherichia coli

Source & Reference

DRAMP

Other

Active against S. aureus (MIC 3.5 uM), E. coli (MIC 20-25 uM), K. pneumoniae ATCC 10031 (MIC 6.25 uM), and C. albicans (MIC 19 uM). Virus: AR-23 exhibi
Evidence 12 Activity

Activity

MIC
Antiparasitic
6.25 µM

Target

Klebsiella pneumoniae ATCC 10031

Source & Reference

DRAMP

Other

Active against S. aureus (MIC 3.5 uM), E. coli (MIC 20-25 uM), K. pneumoniae ATCC 10031 (MIC 6.25 uM), and C. albicans (MIC 19 uM). Virus: AR-23 exhibited a greater inhibitory activity in the
Evidence 13 Activity

Activity

MIC
Antiparasitic
19 µM

Target

Candida albicans

Source & Reference

DRAMP

Other

aureus (MIC 3.5 uM), E. coli (MIC 20-25 uM), K. pneumoniae ATCC 10031 (MIC 6.25 uM), and C. albicans (MIC 19 uM). Virus: AR-23 exhibited a greater inhibitory activity in the early stages of infection ag
Evidence 14 Activity

Activity

MIC
Antiviral
3.5 µM

Target

Staphylococcus aureus

Source & Reference

DRAMP DRAVP 2.0

Other

Source Activity Label Source Definition
Antiviral
DRAMP antiviral activity supported by activity records against viral targets.
Active against S. aureus (MIC 3.5 uM), E. coli (MIC 20-25 uM), K. pneumoniae ATCC 10031 (MIC 6.25 uM), and C. albicans (MIC 19
Evidence 15 Activity

Activity

MIC
Antiviral
20-25 µM

Target

Escherichia coli

Source & Reference

DRAMP DRAVP 2.0

Other

Active against S. aureus (MIC 3.5 uM), E. coli (MIC 20-25 uM), K. pneumoniae ATCC 10031 (MIC 6.25 uM), and C. albicans (MIC 19 uM). Virus: AR-23 exhibi
Evidence 16 Activity

Activity

MIC
Antiviral
6.25 µM

Target

Klebsiella pneumoniae ATCC 10031

Source & Reference

DRAMP DRAVP 2.0

Other

Active against S. aureus (MIC 3.5 uM), E. coli (MIC 20-25 uM), K. pneumoniae ATCC 10031 (MIC 6.25 uM), and C. albicans (MIC 19 uM). Virus: AR-23 exhibited a greater inhibitory activity in the
Evidence 17 Activity

Activity

MIC
Antiviral
19 µM

Target

Candida albicans

Source & Reference

DRAMP DRAVP 2.0

Other

aureus (MIC 3.5 uM), E. coli (MIC 20-25 uM), K. pneumoniae ATCC 10031 (MIC 6.25 uM), and C. albicans (MIC 19 uM). Virus: AR-23 exhibited a greater inhibitory activity in the early stages of infection ag
Evidence 18 Activity

Activity

50% Hemolysis
Toxicity
8 µM
Hemolytic Cytotoxic
50% Hemolysis | 8 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Evidence 19 Activity

Activity

50% Cell death
Toxicity
20 µM
Cytotoxic
50% Cell death | 20 | µM | target cell: Mouse fibroblasts L929

Target

Mouse fibroblasts L929

Source & Reference

NA
DBAASP
A melittin-related peptide from the skin of the Japanese frog, Rana tagoi, with antimicrobial and cytolytic properties | Biochem Biophys Res Commun | 2003
Evidence 20 Activity

Activity

10% Hemolysis
Toxicity
3.13 µM
Hemolytic Cytotoxic
10% Hemolysis | 3.13 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Design of an ?-helical antimicrobial peptide with improved cell-selective and potent anti-biofilm activity. | Sci Rep | 2016
Evidence 21 Activity

Activity

LC50
Toxicity
20 µM
Hemolytic Cytotoxic
Hemolytic_activity: [Ref.27271216] 100% hemolysis at 20 µM against human red blood cells | Cytotoxicity: [Ref.12804591]Display cytotoxic against L929 fibroblasts(LC50=20 µM) EL4 T-lymphoma cells(LC50=14 µM).##[Ref.27271216]L929 cells:Cell viability is approximately 10% at the concentration of 6.25 µM.

Target

erythrocytes

Source & Reference

NA
DRAMP
Biochem Biophys Res Commun. 2003 Jun 27 306(2):496-500.##Peptides. 2007 28(3):505-514.##Sci Rep. 2016 Jun 8 6:27394.
Evidence 22 Hemolysis

Source & Reference

APD_complete APD_hemolytic PD_Hemolysis
APD_complete APD_hemolytic PD_Hemolysis

Other

Source Activity Label Source Definition
Hemolysis
APD_complete APD-derived hemolytic peptide annotation. APD_hemolytic APD hemolytic peptide annotation.