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Peptide record

TPDB10217

Antibacterial Anticancer Antifungal Antiparasitic Antiviral Hemolysis Toxicity standard
23 amino acids
Basic Information
3D PDB MODEL
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TPDB10217
Antibacterial Anticancer Antifungal Antiparasitic Antiviral Hemolysis Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia Antifungipept CAFPdb APD_complete HemoPI Hemolytic2 PD_Hemolysis ToxinPred 3.0
standard
No
A 23-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
GLKEIFKAGLGSLVKGIAAHVAS
Physicochemical Analysis
C104H176N28O28
RNDCQMPTWY
AG
2266.71
10.32
4
1
12
+2
2.28
0.748
127.39
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
0
0.00
2
Residue Composition
number
4
A
0
R
0
N
0
D
0
C
1
E
0
Q
4
G
1
H
2
I
3
L
3
K
0
M
1
F
0
P
2
S
0
T
0
W
0
Y
2
V
Amino Acid Distribution
A: 4 R: 0 N: 0 D: 0 C: 0 E: 1 Q: 0 G: 4 H: 1 I: 2 L: 3 K: 3 M: 0 F: 1 P: 0 S: 2 T: 0 W: 0 Y: 0 V: 2
Chemical Descriptors
23
C104H176N28O28
2266.71
10.32
+2
2.28
0.748
Evidence Records 10 records
Evidence 1 Activity

Activity

MIC
Antibacterial
25 µM

Target

Escherichia coli

Source & Reference

dbAMP DRAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class. DRAMP antibacterial activity supported by MIC records against bacterial target organisms.
Active against primarily G- bacteria such as E. coli (MIC 25 uM).
Evidence 2 Activity

Activity

MIC
Antifungal
25 µM

Target

Escherichia coli

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class. DRAMP antifungal activity supported by activity records against fungal target organisms.
Active against primarily G- bacteria such as E. coli (MIC 25 uM).
Evidence 3 Activity

Activity

MIC
Antiparasitic
25 µM

Target

Escherichia coli

Source & Reference

DRAMP

Other

Source Activity Label Source Definition
Antiparasitic
DRAMP antiparasitic activity supported by activity records against parasitic targets.
Active against primarily G- bacteria such as E. coli (MIC 25 uM).
Evidence 4 Activity

Activity

MIC
Antiviral
25 µM

Target

Escherichia coli

Source & Reference

DRAMP

Other

Source Activity Label Source Definition
Antiviral
DRAMP antiviral activity supported by activity records against viral targets.
Active against primarily G- bacteria such as E. coli (MIC 25 uM).
Evidence 5 Activity

Activity

LC50
Hemolysis
145 µM
[Ref:19463738] LC50 = 145 µM against human erthrocytes.

Source & Reference

Hemolytik APD_complete PD_Hemolysis
DRAMP4
Biochim Biophys Acta. 2011 Aug 1808(8):1975-1984.##Peptides. 2009 Jun 30(6):1069-1073.

Other

Source Activity Label Source Definition
Hemolysis
APD_complete APD-derived hemolytic peptide annotation. Hemolytik experimentally validated hemolytic peptide annotation.
Evidence 6 Activity

Activity

0% Hemolysis
Toxicity
62.5 µM
Hemolytic Cytotoxic
0% Hemolysis | 62.5 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Increases in Hydrophilicity and Charge on the Polar Face of Alyteserin 1c Helix Change its Selectivity towards Gram-Positive Bacteria. | Antibiotics (Basel) | 2019
Evidence 7 Activity

Activity

2% Hemolysis
Toxicity
125 µM
Hemolytic Cytotoxic
2% Hemolysis | 125 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Increases in Hydrophilicity and Charge on the Polar Face of Alyteserin 1c Helix Change its Selectivity towards Gram-Positive Bacteria. | Antibiotics (Basel) | 2019
Evidence 8 Activity

Activity

50% Hemolysis
Toxicity
145 µM
Hemolytic Cytotoxic
50% Hemolysis | 145 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
The alyteserins: two families of antimicrobial peptides from the skin secretions of the midwife toad Alytes obstetricans (Alytidae). | Peptides | 2009
Evidence 9 Activity

Activity

LC50
Toxicity
145 µM
Hemolytic
Hemolytic_activity: [Ref:19463738] LC50 = 145 µM against human erthrocytes.

Target

erythrocytes

Source & Reference

NA
DRAMP
Biochim Biophys Acta. 2011 Aug 1808(8):1975-1984.##Peptides. 2009 Jun 30(6):1069-1073.
Evidence 10 Hemolysis

Activity

145 µM
LC50
[Ref:19463738] LC50 = 145 µM against human erthrocytes.
Hemolysis

Source & Reference

APD_complete HemoPI PD_Hemolysis
Biochim Biophys Acta. 2011 Aug 1808(8):1975-1984.##Peptides. 2009 Jun 30(6):1069-1073.
DRAMP4
APD_complete PD_Hemolysis

Other

Source Activity Label Source Definition
Hemolysis
APD_complete APD-derived hemolytic peptide annotation.