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Peptide record

TPDB10216

Antibacterial Anticancer Antifungal Antiparasitic Toxicity standard
23 amino acids
Basic Information
3D PDB MODEL
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TPDB10216
Antibacterial Anticancer Antifungal Antiparasitic Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia AntiCP 2.0 iACP-DRLF AFP-GFuse Antifungipept CAFPdb ToxinPred 3.0
standard
No
A 23-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
RIIDLLWRVRRPQKPKFVTVWVR
Physicochemical Analysis
C140H229N43O28
ANCEGHMSY
R
2962.63
12.58
7
1
11
+6
2.59
-0.296
118.26
Mammalian: 1 hour Yeast: 2 min E.coli: 2 min
11000
371.29
2
Residue Composition
number
0
A
5
R
0
N
1
D
0
C
0
E
1
Q
0
G
0
H
2
I
2
L
2
K
0
M
1
F
2
P
0
S
1
T
2
W
0
Y
4
V
Amino Acid Distribution
A: 0 R: 5 N: 0 D: 1 C: 0 E: 0 Q: 1 G: 0 H: 0 I: 2 L: 2 K: 2 M: 0 F: 1 P: 2 S: 0 T: 1 W: 2 Y: 0 V: 4
Chemical Descriptors
23
C140H229N43O28
2962.63
12.58
+6
2.59
-0.296
Evidence Records 32 records
Evidence 1 Activity

Activity

MIC
Antibacterial
2-4 µM

Target

Escherichia coli ML35 or ATCC 25922

Source & Reference

dbAMP DRAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class. DRAMP antibacterial activity supported by MIC records against bacterial target organisms.
Active against E. coli ML35 or ATCC 25922 (MIC 2-4 uM), S. typhimurium ATCC 14028 (MIC 8 uM), P. aeruginosa ATCC 27853 (MIC 16 uM), B. megateriu
Evidence 2 Activity

Activity

MIC
Antibacterial
8 µM

Target

S. typhimurium ATCC 14028

Source & Reference

dbAMP DRAMP

Other

Active against E. coli ML35 or ATCC 25922 (MIC 2-4 uM), S. typhimurium ATCC 14028 (MIC 8 uM), P. aeruginosa ATCC 27853 (MIC 16 uM), B. megaterium local isolate (MIC 2 uM), and S. aur
Evidence 3 Activity

Activity

MIC
Antibacterial
16 µM

Target

Pseudomonas aeruginosa ATCC 27853

Source & Reference

dbAMP DRAMP

Other

ve against E. coli ML35 or ATCC 25922 (MIC 2-4 uM), S. typhimurium ATCC 14028 (MIC 8 uM), P. aeruginosa ATCC 27853 (MIC 16 uM), B. megaterium local isolate (MIC 2 uM), and S. aureus ATCC 25923 (MIC 4 uM) (see ref). A
Evidence 4 Activity

Activity

MIC
Antibacterial
2 µM

Target

B. megaterium local isolate

Source & Reference

dbAMP DRAMP

Other

(MIC 2-4 uM), S. typhimurium ATCC 14028 (MIC 8 uM), P. aeruginosa ATCC 27853 (MIC 16 uM), B. megaterium local isolate (MIC 2 uM), and S. aureus ATCC 25923 (MIC 4 uM) (see ref). Also C-termindated PMAP-23 antifungal aga
Evidence 5 Activity

Activity

MIC
Antibacterial
4 µM

Target

Staphylococcus aureus ATCC 25923

Source & Reference

dbAMP DRAMP

Other

8 uM), P. aeruginosa ATCC 27853 (MIC 16 uM), B. megaterium local isolate (MIC 2 uM), and S. aureus ATCC 25923 (MIC 4 uM) (see ref). Also C-termindated PMAP-23 antifungal against C. albicans (MIC 2.5-5 uM), S. c
Evidence 6 Activity

Activity

MIC
Antibacterial
2.5-5 µM

Target

Candida albicans

Source & Reference

dbAMP DRAMP

Other

S. aureus ATCC 25923 (MIC 4 uM) (see ref). Also C-termindated PMAP-23 antifungal against C. albicans (MIC 2.5-5 uM), S. cerevisiae (MIC 5 uM) and T. beigelii (MIC 2-5 uM) ( Lee DG et al., 2001 ). Also exer
Evidence 7 Activity

Activity

MIC
Antibacterial
5 µM

Target

S. cerevisiae

Source & Reference

dbAMP DRAMP

Other

uM) (see ref). Also C-termindated PMAP-23 antifungal against C. albicans (MIC 2.5-5 uM), S. cerevisiae (MIC 5 uM) and T. beigelii (MIC 2-5 uM) ( Lee DG et al., 2001 ). Also exerted strong nematocidal act
Evidence 8 Activity

Activity

MIC
Antibacterial
2-5 µM

Target

T. beigelii

Source & Reference

dbAMP DRAMP

Other

dated PMAP-23 antifungal against C. albicans (MIC 2.5-5 uM), S. cerevisiae (MIC 5 uM) and T. beigelii (MIC 2-5 uM) ( Lee DG et al., 2001 ). Also exerted strong nematocidal activity against C. elegans.
Evidence 9 Activity

Activity

MIC
Antifungal
2-4 µM

Target

Escherichia coli ML35 or ATCC 25922

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class. DRAMP antifungal activity supported by activity records against fungal target organisms.
Active against E. coli ML35 or ATCC 25922 (MIC 2-4 uM), S. typhimurium ATCC 14028 (MIC 8 uM), P. aeruginosa ATCC 27853 (MIC 16 uM), B. megateriu
Evidence 10 Activity

Activity

MIC
Antifungal
8 µM

Target

S. typhimurium ATCC 14028

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Active against E. coli ML35 or ATCC 25922 (MIC 2-4 uM), S. typhimurium ATCC 14028 (MIC 8 uM), P. aeruginosa ATCC 27853 (MIC 16 uM), B. megaterium local isolate (MIC 2 uM), and S. aur
Evidence 11 Activity

Activity

MIC
Antifungal
16 µM

Target

Pseudomonas aeruginosa ATCC 27853

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

ve against E. coli ML35 or ATCC 25922 (MIC 2-4 uM), S. typhimurium ATCC 14028 (MIC 8 uM), P. aeruginosa ATCC 27853 (MIC 16 uM), B. megaterium local isolate (MIC 2 uM), and S. aureus ATCC 25923 (MIC 4 uM) (see ref). A
Evidence 12 Activity

Activity

MIC
Antifungal
2 µM

Target

B. megaterium local isolate

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

(MIC 2-4 uM), S. typhimurium ATCC 14028 (MIC 8 uM), P. aeruginosa ATCC 27853 (MIC 16 uM), B. megaterium local isolate (MIC 2 uM), and S. aureus ATCC 25923 (MIC 4 uM) (see ref). Also C-termindated PMAP-23 antifungal aga
Evidence 13 Activity

Activity

MIC
Antifungal
4 µM

Target

Staphylococcus aureus ATCC 25923

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

8 uM), P. aeruginosa ATCC 27853 (MIC 16 uM), B. megaterium local isolate (MIC 2 uM), and S. aureus ATCC 25923 (MIC 4 uM) (see ref). Also C-termindated PMAP-23 antifungal against C. albicans (MIC 2.5-5 uM), S. c
Evidence 14 Activity

Activity

MIC
Antifungal
2.5-5 µM

Target

Candida albicans

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

S. aureus ATCC 25923 (MIC 4 uM) (see ref). Also C-termindated PMAP-23 antifungal against C. albicans (MIC 2.5-5 uM), S. cerevisiae (MIC 5 uM) and T. beigelii (MIC 2-5 uM) ( Lee DG et al., 2001 ). Also exer
Evidence 15 Activity

Activity

MIC
Antifungal
5 µM

Target

S. cerevisiae

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

uM) (see ref). Also C-termindated PMAP-23 antifungal against C. albicans (MIC 2.5-5 uM), S. cerevisiae (MIC 5 uM) and T. beigelii (MIC 2-5 uM) ( Lee DG et al., 2001 ). Also exerted strong nematocidal act
Evidence 16 Activity

Activity

MIC
Antifungal
2-5 µM

Target

T. beigelii

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

dated PMAP-23 antifungal against C. albicans (MIC 2.5-5 uM), S. cerevisiae (MIC 5 uM) and T. beigelii (MIC 2-5 uM) ( Lee DG et al., 2001 ). Also exerted strong nematocidal activity against C. elegans.
Evidence 17 Activity

Activity

MIC
Antiparasitic
2-4 µM

Target

Escherichia coli ML35 or ATCC 25922

Source & Reference

DRAMP

Other

Source Activity Label Source Definition
Antiparasitic
DRAMP antiparasitic activity supported by activity records against parasitic targets.
Active against E. coli ML35 or ATCC 25922 (MIC 2-4 uM), S. typhimurium ATCC 14028 (MIC 8 uM), P. aeruginosa ATCC 27853 (MIC 16 uM), B. megateriu
Evidence 18 Activity

Activity

MIC
Antiparasitic
8 µM

Target

S. typhimurium ATCC 14028

Source & Reference

DRAMP

Other

Active against E. coli ML35 or ATCC 25922 (MIC 2-4 uM), S. typhimurium ATCC 14028 (MIC 8 uM), P. aeruginosa ATCC 27853 (MIC 16 uM), B. megaterium local isolate (MIC 2 uM), and S. aur
Evidence 19 Activity

Activity

MIC
Antiparasitic
16 µM

Target

Pseudomonas aeruginosa ATCC 27853

Source & Reference

DRAMP

Other

ve against E. coli ML35 or ATCC 25922 (MIC 2-4 uM), S. typhimurium ATCC 14028 (MIC 8 uM), P. aeruginosa ATCC 27853 (MIC 16 uM), B. megaterium local isolate (MIC 2 uM), and S. aureus ATCC 25923 (MIC 4 uM) (see ref). A
Evidence 20 Activity

Activity

MIC
Antiparasitic
2 µM

Target

B. megaterium local isolate

Source & Reference

DRAMP

Other

(MIC 2-4 uM), S. typhimurium ATCC 14028 (MIC 8 uM), P. aeruginosa ATCC 27853 (MIC 16 uM), B. megaterium local isolate (MIC 2 uM), and S. aureus ATCC 25923 (MIC 4 uM) (see ref). Also C-termindated PMAP-23 antifungal aga
Evidence 21 Activity

Activity

MIC
Antiparasitic
4 µM

Target

Staphylococcus aureus ATCC 25923

Source & Reference

DRAMP

Other

8 uM), P. aeruginosa ATCC 27853 (MIC 16 uM), B. megaterium local isolate (MIC 2 uM), and S. aureus ATCC 25923 (MIC 4 uM) (see ref). Also C-termindated PMAP-23 antifungal against C. albicans (MIC 2.5-5 uM), S. c
Evidence 22 Activity

Activity

MIC
Antiparasitic
2.5-5 µM

Target

Candida albicans

Source & Reference

DRAMP

Other

S. aureus ATCC 25923 (MIC 4 uM) (see ref). Also C-termindated PMAP-23 antifungal against C. albicans (MIC 2.5-5 uM), S. cerevisiae (MIC 5 uM) and T. beigelii (MIC 2-5 uM) ( Lee DG et al., 2001 ). Also exer
Evidence 23 Activity

Activity

MIC
Antiparasitic
5 µM

Target

S. cerevisiae

Source & Reference

DRAMP

Other

uM) (see ref). Also C-termindated PMAP-23 antifungal against C. albicans (MIC 2.5-5 uM), S. cerevisiae (MIC 5 uM) and T. beigelii (MIC 2-5 uM) ( Lee DG et al., 2001 ). Also exerted strong nematocidal act
Evidence 24 Activity

Activity

MIC
Antiparasitic
2-5 µM

Target

T. beigelii

Source & Reference

DRAMP

Other

dated PMAP-23 antifungal against C. albicans (MIC 2.5-5 uM), S. cerevisiae (MIC 5 uM) and T. beigelii (MIC 2-5 uM) ( Lee DG et al., 2001 ). Also exerted strong nematocidal activity against C. elegans.
Evidence 25 Activity

Activity

4.8% Hemolysis
Toxicity
100 µM
Hemolytic Cytotoxic
4.8% Hemolysis | 100 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
C-terminal amidation of PMAP-23: translocation to the inner membrane of Gram-negative bacteria. | Amino Acids | 2011
Evidence 26 Activity

Activity

25% Killing
Toxicity
100 µM
Cytotoxic
25% Killing | 100 | µM | target cell: Human keratinocytes HaCat

Target

Human keratinocytes HaCat

Source & Reference

NA
DBAASP
C-terminal amidation of PMAP-23: translocation to the inner membrane of Gram-negative bacteria. | Amino Acids | 2011
Evidence 27 Activity

Activity

5% Hemolysis
Toxicity
128 µM
Hemolytic Cytotoxic
5% Hemolysis | 128 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Broad-spectrum hybrid antimicrobial peptides derived from PMAP-23 with potential LPS binding ability. | Biochem Pharmacol | 2023
Evidence 28 Activity

Activity

0% Hemolysis
Toxicity
100 µM
Hemolytic Cytotoxic
0% Hemolysis | 100 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Effects of tryptophan residues of porcine myeloid antibacterial peptide PMAP-23 on antibiotic activity. | Biochem Biophys Res Commun | 1999
Evidence 29 Activity

Activity

15.4% Hemolysis
Toxicity
100 µM
Hemolytic Cytotoxic
15.4% Hemolysis | 100 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
C-terminal amidation of PMAP-23: translocation to the inner membrane of Gram-negative bacteria. | Amino Acids | 2011
Evidence 30 Activity

Activity

29% Cell death
Toxicity
100 µM
Cytotoxic
29% Cell death | 100 | µM | target cell: Human keratinocytes HaCat

Target

Human keratinocytes HaCat

Source & Reference

NA
DBAASP
C-terminal amidation of PMAP-23: translocation to the inner membrane of Gram-negative bacteria. | Amino Acids | 2011
Evidence 31 Activity

Activity

<4% Hemolysis
Toxicity
1000 µg/mL
Hemolytic Cytotoxic
<4% Hemolysis | 1000 | µg/mL | target cell: Mouse erythrocytes

Target

Mouse erythrocytes

Source & Reference

NA
DBAASP
Analogs of the Cathelicidin-Derived Antimicrobial Peptide PMAP-23 Exhibit Improved Stability and Antibacterial Activity. | Probiotics Antimicrob Proteins | 2020
Evidence 32 Activity

Activity

Toxicity
Cytotoxic
NA | target cell: Mouse fibroblasts NIH 3T3

Target

Mouse fibroblasts NIH 3T3

Source & Reference

NA
DBAASP
Analogs of the Cathelicidin-Derived Antimicrobial Peptide PMAP-23 Exhibit Improved Stability and Antibacterial Activity. | Probiotics Antimicrob Proteins | 2020