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Peptide record

TPDB10215

Antibacterial Anticancer Antifungal Antiparasitic Antiviral Toxicity standard
23 amino acids
Basic Information
3D PDB MODEL
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TPDB10215
Antibacterial Anticancer Antifungal Antiparasitic Antiviral Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia Antifungipept CAFPdb AI4AVP dbAMP 3.0 DRAVP 2.0 ToxinPred 3.0
standard
No
A 23-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
GIGKFLHSAGKFGKAFVGEIMKS
Physicochemical Analysis
C112H177N29O28S1
RNDCQPTWY
G
2409.88
10.55
5
1
10
+3
2.18
0.217
72.17
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
0
0.00
2
Residue Composition
number
2
A
0
R
0
N
0
D
0
C
1
E
0
Q
5
G
1
H
2
I
1
L
4
K
1
M
3
F
0
P
2
S
0
T
0
W
0
Y
1
V
Amino Acid Distribution
A: 2 R: 0 N: 0 D: 0 C: 0 E: 1 Q: 0 G: 5 H: 1 I: 2 L: 1 K: 4 M: 1 F: 3 P: 0 S: 2 T: 0 W: 0 Y: 0 V: 1
Chemical Descriptors
23
C112H177N29O28S1
2409.88
10.55
+3
2.18
0.217
Evidence Records 14 records
Evidence 1 Activity

Activity

MIC
Antibacterial
22.2 µg/mL

Target

Staphylococcus aureus 930918-3

Source & Reference

dbAMP DRAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class. DRAMP antibacterial activity supported by MIC records against bacterial target organisms.
Active against Gram+ S. aureus 930918-3 (MIC 22.2 ug/ml), E. faecalis CDC 21, L. monocytogenes EGD (MIC 3-7 ug/ml), Gram- E. coli ML-35p, E. coli
Evidence 2 Activity

Activity

MIC
Antibacterial
3-7 µg/mL

Target

L. monocytogenes EGD

Source & Reference

dbAMP DRAMP

Other

Active against Gram+ S. aureus 930918-3 (MIC 22.2 ug/ml), E. faecalis CDC 21, L. monocytogenes EGD (MIC 3-7 ug/ml), Gram- E. coli ML-35p, E. coli mcr 106, E. coli BAS 849, S. typhimurium 14028S, S. typhim
Evidence 3 Activity

Activity

MIC
Antibacterial
0.4-1.8 µg/mL

Target

Pseudomonas aeruginosa MR3007

Source & Reference

dbAMP DRAMP

Other

S. typhimurium 7953S, K. pneumoniae 2270, P. aeruginosa SBI-N, P. aeruginosa MR2123, and P. aeruginosa MR3007 (MIC 0.4-1.8 ug/ml) ( Lee IH et al., 1997 ). It also inhibits Herpes Simplex Virus type 1 (HSV-1) and HSV-2 (
Evidence 4 Activity

Activity

MIC
Antifungal
22.2 µg/mL

Target

Staphylococcus aureus 930918-3

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class. DRAMP antifungal activity supported by activity records against fungal target organisms.
Active against Gram+ S. aureus 930918-3 (MIC 22.2 ug/ml), E. faecalis CDC 21, L. monocytogenes EGD (MIC 3-7 ug/ml), Gram- E. coli ML-35p, E. coli
Evidence 5 Activity

Activity

MIC
Antifungal
3-7 µg/mL

Target

L. monocytogenes EGD

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Active against Gram+ S. aureus 930918-3 (MIC 22.2 ug/ml), E. faecalis CDC 21, L. monocytogenes EGD (MIC 3-7 ug/ml), Gram- E. coli ML-35p, E. coli mcr 106, E. coli BAS 849, S. typhimurium 14028S, S. typhim
Evidence 6 Activity

Activity

MIC
Antifungal
0.4-1.8 µg/mL

Target

Pseudomonas aeruginosa MR3007

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

S. typhimurium 7953S, K. pneumoniae 2270, P. aeruginosa SBI-N, P. aeruginosa MR2123, and P. aeruginosa MR3007 (MIC 0.4-1.8 ug/ml) ( Lee IH et al., 1997 ). It also inhibits Herpes Simplex Virus type 1 (HSV-1) and HSV-2 (
Evidence 7 Activity

Activity

MIC
Antiparasitic
22.2 µg/mL

Target

Staphylococcus aureus 930918-3

Source & Reference

dbAMP 3.0 DRAMP

Other

Source Activity Label Source Definition
Antiparasitic
DRAMP antiparasitic activity supported by activity records against parasitic targets. dbAMP 3.0 classified under the Anti-parasitic function class.
Active against Gram+ S. aureus 930918-3 (MIC 22.2 ug/ml), E. faecalis CDC 21, L. monocytogenes EGD (MIC 3-7 ug/ml), Gram- E. coli ML-35p, E. coli
Evidence 8 Activity

Activity

MIC
Antiparasitic
3-7 µg/mL

Target

L. monocytogenes EGD

Source & Reference

dbAMP 3.0 DRAMP

Other

Active against Gram+ S. aureus 930918-3 (MIC 22.2 ug/ml), E. faecalis CDC 21, L. monocytogenes EGD (MIC 3-7 ug/ml), Gram- E. coli ML-35p, E. coli mcr 106, E. coli BAS 849, S. typhimurium 14028S, S. typhim
Evidence 9 Activity

Activity

MIC
Antiparasitic
0.4-1.8 µg/mL

Target

Pseudomonas aeruginosa MR3007

Source & Reference

dbAMP 3.0 DRAMP

Other

S. typhimurium 7953S, K. pneumoniae 2270, P. aeruginosa SBI-N, P. aeruginosa MR2123, and P. aeruginosa MR3007 (MIC 0.4-1.8 ug/ml) ( Lee IH et al., 1997 ). It also inhibits Herpes Simplex Virus type 1 (HSV-1) and HSV-2 (
Evidence 10 Activity

Activity

MIC
Antiviral
22.2 µg/mL

Target

Staphylococcus aureus 930918-3

Source & Reference

dbAMP 3.0 DRAMP DRAVP 2.0

Other

Source Activity Label Source Definition
Antiviral
DRAMP antiviral activity supported by activity records against viral targets. dbAMP 3.0 classified under the Anti-viral function class.
Active against Gram+ S. aureus 930918-3 (MIC 22.2 ug/ml), E. faecalis CDC 21, L. monocytogenes EGD (MIC 3-7 ug/ml), Gram- E. coli ML-35p, E. coli
Evidence 11 Activity

Activity

MIC
Antiviral
3-7 µg/mL

Target

L. monocytogenes EGD

Source & Reference

dbAMP 3.0 DRAMP DRAVP 2.0

Other

Active against Gram+ S. aureus 930918-3 (MIC 22.2 ug/ml), E. faecalis CDC 21, L. monocytogenes EGD (MIC 3-7 ug/ml), Gram- E. coli ML-35p, E. coli mcr 106, E. coli BAS 849, S. typhimurium 14028S, S. typhim
Evidence 12 Activity

Activity

MIC
Antiviral
0.4-1.8 µg/mL

Target

Pseudomonas aeruginosa MR3007

Source & Reference

dbAMP 3.0 DRAMP DRAVP 2.0

Other

S. typhimurium 7953S, K. pneumoniae 2270, P. aeruginosa SBI-N, P. aeruginosa MR2123, and P. aeruginosa MR3007 (MIC 0.4-1.8 ug/ml) ( Lee IH et al., 1997 ). It also inhibits Herpes Simplex Virus type 1 (HSV-1) and HSV-2 (
Evidence 13 Activity

Activity

3% Hemolysis
Toxicity
500 µg/mL
Hemolytic Cytotoxic
3% Hemolysis | 500 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Synthetic magainin analogues with improved antimicrobial activity | FEBS Lett | 1988
Evidence 14 Activity

Activity

0% Hemolysis
Toxicity
80 µg/mL
Hemolytic Cytotoxic
0% Hemolysis | 80 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Evaluation of the inactivation of infectious Herpes simplex virus by host-defense peptides. | Eur J Clin Microbiol Infect Dis | 2000