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Peptide record

TPDB10214

Antibacterial Anticancer Antifungal Antiparasitic Hemolysis Toxicity standard
23 amino acids
Basic Information
3D PDB MODEL
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TPDB10214
Antibacterial Anticancer Antifungal Antiparasitic Hemolysis Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia AFP-GFuse Antifungipept CAFPdb dbAMP 3.0 i2APP APD_complete HemoPI Hemolytic2 PD_Hemolysis ToxinPred 3.0
standard
No
A 23-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
VFQFLGKIIHHVGNFVHGFSHVF
Physicochemical Analysis
C131H184N34O27
ARDCEMPTWY
F
2667.11
10.10
5
0
12
+1
-0.56
0.778
101.30
Mammalian: 100 hour Yeast: >20 hour E.coli: >10 hour
0
0.00
3
Residue Composition
number
0
A
0
R
1
N
0
D
0
C
0
E
1
Q
3
G
4
H
2
I
1
L
1
K
0
M
5
F
0
P
1
S
0
T
0
W
0
Y
4
V
Amino Acid Distribution
A: 0 R: 0 N: 1 D: 0 C: 0 E: 0 Q: 1 G: 3 H: 4 I: 2 L: 1 K: 1 M: 0 F: 5 P: 0 S: 1 T: 0 W: 0 Y: 0 V: 4
Chemical Descriptors
23
C131H184N34O27
2667.11
10.10
+1
-0.56
0.778
Evidence Records 16 records
Evidence 1 Activity

Activity

MIC
Antibacterial
0.2-3.8 µg/mL

Target

L. monocytogenes EGD

Source & Reference

dbAMP DRAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class. DRAMP antibacterial activity supported by MIC records against bacterial target organisms.
tive against Gram+ S. aureus 930918-3 or ATCC 30371 or 28841 or MRSA, E. faecalis CDC 21, L. monocytogenes EGD (MIC 0.2-3.8 ug/ml), Gram- E. coli mcr 106, E. coli BAS 849, S. typhimurium 14028S, S. typhimurium 7953S, K.
Evidence 2 Activity

Activity

MIC
Antibacterial
0.4-2.1 µg/mL

Target

Pseudomonas aeruginosa MR3007

Source & Reference

dbAMP DRAMP

Other

S. typhimurium 7953S, K. pneumoniae 2270, P. aeruginosa SBI-N, P. aeruginosa MR2123, and P. aeruginosa MR3007 (MIC 0.4-2.1 ug/ml) ( Lee IH et al., 1997 ).
Evidence 3 Activity

Activity

MIC
Antifungal
0.2-3.8 µg/mL

Target

L. monocytogenes EGD

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class. DRAMP antifungal activity supported by activity records against fungal target organisms.
tive against Gram+ S. aureus 930918-3 or ATCC 30371 or 28841 or MRSA, E. faecalis CDC 21, L. monocytogenes EGD (MIC 0.2-3.8 ug/ml), Gram- E. coli mcr 106, E. coli BAS 849, S. typhimurium 14028S, S. typhimurium 7953S, K.
Evidence 4 Activity

Activity

MIC
Antifungal
0.4-2.1 µg/mL

Target

Pseudomonas aeruginosa MR3007

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

S. typhimurium 7953S, K. pneumoniae 2270, P. aeruginosa SBI-N, P. aeruginosa MR2123, and P. aeruginosa MR3007 (MIC 0.4-2.1 ug/ml) ( Lee IH et al., 1997 ).
Evidence 5 Activity

Activity

MIC
Antiparasitic
0.2-3.8 µg/mL

Target

L. monocytogenes EGD

Source & Reference

dbAMP 3.0 DRAMP

Other

Source Activity Label Source Definition
Antiparasitic
DRAMP antiparasitic activity supported by activity records against parasitic targets. dbAMP 3.0 classified under the Anti-parasitic function class.
tive against Gram+ S. aureus 930918-3 or ATCC 30371 or 28841 or MRSA, E. faecalis CDC 21, L. monocytogenes EGD (MIC 0.2-3.8 ug/ml), Gram- E. coli mcr 106, E. coli BAS 849, S. typhimurium 14028S, S. typhimurium 7953S, K.
Evidence 6 Activity

Activity

MIC
Antiparasitic
0.4-2.1 µg/mL

Target

Pseudomonas aeruginosa MR3007

Source & Reference

dbAMP 3.0 DRAMP

Other

S. typhimurium 7953S, K. pneumoniae 2270, P. aeruginosa SBI-N, P. aeruginosa MR2123, and P. aeruginosa MR3007 (MIC 0.4-2.1 ug/ml) ( Lee IH et al., 1997 ).
Evidence 7 Activity

Activity

10% Hemolysis
Toxicity
50 µM
Hemolytic Cytotoxic
10% Hemolysis | 50 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Trypanocidal and leishmanicidal activities of different antimicrobial peptides (AMPs) isolated from aquatic animals | Exp Parasitol | 2008
Evidence 8 Activity

Activity

4% Hemolysis
Toxicity
80 µg/mL
Hemolytic Cytotoxic
4% Hemolysis | 80 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Evaluation of the inactivation of infectious Herpes simplex virus by host-defense peptides. | Eur J Clin Microbiol Infect Dis | 2000
Evidence 9 Activity

Activity

<10% Hemolysis
Toxicity
200 µM
Hemolytic Cytotoxic
<10% Hemolysis | 200 | µM | target cell: Mouse erythrocytes

Target

Mouse erythrocytes

Source & Reference

NA
DBAASP
An anti-infective synthetic peptide with dual antimicrobial and immunomodulatory activities. | Sci Rep | 2016
Evidence 10 Activity

Activity

LC50
Toxicity
>600 µM
Cytotoxic
LC50 | >600 | µM | target cell: Mouse fibroblasts L929

Target

Mouse fibroblasts L929

Source & Reference

NA
DBAASP
An anti-infective synthetic peptide with dual antimicrobial and immunomodulatory activities. | Sci Rep | 2016
Evidence 11 Activity

Activity

LC50
Toxicity
>600 µM
Cytotoxic
LC50 | >600 | µM | target cell: Human embryonic kidney HEK293 cells

Target

Human embryonic kidney HEK293 cells

Source & Reference

NA
DBAASP
An anti-infective synthetic peptide with dual antimicrobial and immunomodulatory activities. | Sci Rep | 2016
Evidence 12 Activity

Activity

0% Hemolysis
Toxicity
80 µg/mL
Hemolytic Cytotoxic
0% Hemolysis | 80 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Evaluation of the inactivation of infectious Herpes simplex virus by host-defense peptides. | Eur J Clin Microbiol Infect Dis | 2000
Evidence 13 Activity

Activity

4% Cell death
Toxicity
256 µg/mL
Cytotoxic
4% Cell death | 256 | µg/mL | target cell: Human renal proximal tubular epithelial cells (HRPTEC)

Target

Human renal proximal tubular epithelial cells (HRPTEC)

Source & Reference

NA
DBAASP
Chemical "Butterfly Effect" Explaining the Coordination Chemistry and Antimicrobial Properties of Clavanin Complexes. | Inorg Chem | 2021
Evidence 14 Activity

Activity

0% Cell death
Toxicity
256 µg/mL
Cytotoxic
0% Cell death | 256 | µg/mL | target cell: Human renal proximal tubular epithelial cells (HRPTEC)

Target

Human renal proximal tubular epithelial cells (HRPTEC)

Source & Reference

NA
DBAASP
Chemical "Butterfly Effect" Explaining the Coordination Chemistry and Antimicrobial Properties of Clavanin Complexes. | Inorg Chem | 2021
Evidence 15 Activity

Activity

2% Cell death
Toxicity
128 µg/mL
Cytotoxic
2% Cell death | 128 | µg/mL | target cell: Human renal proximal tubular epithelial cells (HRPTEC)

Target

Human renal proximal tubular epithelial cells (HRPTEC)

Source & Reference

NA
DBAASP
Chemical "Butterfly Effect" Explaining the Coordination Chemistry and Antimicrobial Properties of Clavanin Complexes. | Inorg Chem | 2021
Evidence 16 Hemolysis

Source & Reference

APD_complete HemoPI PD_Hemolysis
APD_complete PD_Hemolysis

Other

Source Activity Label Source Definition
Hemolysis
APD_complete APD-derived hemolytic peptide annotation.