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Peptide record

TPDB10213

Antibacterial Toxicity standard
23 amino acids
Basic Information
3D PDB MODEL
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TPDB10213
Antibacterial Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia
standard
No
A 23-aa standard natural multi-activity (Antibacterial and Toxicity) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
GIGKHVGKALKGLKGLLKGLGEC
Physicochemical Analysis
C102H182N30O26S1
RNDQMFPSTWY
G
2276.81
10.39
6
1
8
+4
4.55
0.130
118.70
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
0
0.00
1
Residue Composition
number
1
A
0
R
0
N
0
D
1
C
1
E
0
Q
7
G
1
H
1
I
5
L
5
K
0
M
0
F
0
P
0
S
0
T
0
W
0
Y
1
V
Amino Acid Distribution
A: 1 R: 0 N: 0 D: 0 C: 1 E: 1 Q: 0 G: 7 H: 1 I: 1 L: 5 K: 5 M: 0 F: 0 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 1
Chemical Descriptors
23
C102H182N30O26S1
2276.81
10.39
+4
4.55
0.130
Evidence Records 2 records
Evidence 1 Activity

Activity

50% Hemolysis
Toxicity
400±100 µM
Hemolytic Cytotoxic
50% Hemolysis | 400±100 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Selective antimicrobial activity and mode of action of adepantins, glycine-rich peptide antibiotics based on anuran antimicrobial peptide sequences. | Biochim Biophys Acta | 2013
Evidence 2 Activity

Activity

50% Hemolysis
Toxicity
16±4 µM
Hemolytic Cytotoxic
50% Hemolysis | 16±4 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Selective antimicrobial activity and mode of action of adepantins, glycine-rich peptide antibiotics based on anuran antimicrobial peptide sequences. | Biochim Biophys Acta | 2013