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Peptide record

TPDB10211

Antibacterial Antifungal Antiparasitic Hemolysis Toxicity standard
23 amino acids
Basic Information
3D PDB MODEL
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TPDB10211
Antibacterial Antifungal Antiparasitic Hemolysis Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia AFP-GFuse Antifungipept CAFPdb dbAMP 3.0 APD_complete PD_Hemolysis ToxinPred 3.0
standard
No
A 23-aa standard natural multi-activity (Antibacterial, Antifungal, Antiparasitic, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
GFLDVVKHIGKAALGAVTHLINQ
Physicochemical Analysis
C110H181N31O29
RCEMPSWY
AGLV
2401.84
9.88
4
1
12
+1
2.57
0.635
135.65
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
0
0.00
3
Residue Composition
number
3
A
0
R
1
N
1
D
0
C
0
E
1
Q
3
G
2
H
2
I
3
L
2
K
0
M
1
F
0
P
0
S
1
T
0
W
0
Y
3
V
Amino Acid Distribution
A: 3 R: 0 N: 1 D: 1 C: 0 E: 0 Q: 1 G: 3 H: 2 I: 2 L: 3 K: 2 M: 0 F: 1 P: 0 S: 0 T: 1 W: 0 Y: 0 V: 3
Chemical Descriptors
23
C110H181N31O29
2401.84
9.88
+1
2.57
0.635
Evidence Records 12 records
Evidence 1 Activity

Activity

Antibacterial

Source & Reference

dbAMP DRAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class.
Active against E. coli (13.3 uM), S. aureus (13.3 uM), and C. albicans (13.3 uM). Updated 7/2021
Evidence 2 Activity

Activity

Antifungal

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class.
Active against E. coli (13.3 uM), S. aureus (13.3 uM), and C. albicans (13.3 uM). Updated 7/2021
Evidence 3 Activity

Activity

Antiparasitic

Source & Reference

dbAMP 3.0 DRAMP

Other

Source Activity Label Source Definition
Antiparasitic
dbAMP 3.0 classified under the Anti-parasitic function class.
Active against E. coli (13.3 uM), S. aureus (13.3 uM), and C. albicans (13.3 uM). Updated 7/2021
Evidence 4 Activity

Activity

1% Hemolysis
Toxicity
4-8 µg/mL
Hemolytic Cytotoxic
1% Hemolysis | 4-8 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Peptidomic approach identifies cruzioseptins, a new family of potent antimicrobial peptides in the splendid leaf frog, Cruziohyla calcarifer. | J Proteomics | 2016
Evidence 5 Activity

Activity

2% Hemolysis
Toxicity
16 µg/mL
Hemolytic Cytotoxic
2% Hemolysis | 16 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Peptidomic approach identifies cruzioseptins, a new family of potent antimicrobial peptides in the splendid leaf frog, Cruziohyla calcarifer. | J Proteomics | 2016
Evidence 6 Activity

Activity

6% Hemolysis
Toxicity
32 µg/mL
Hemolytic Cytotoxic
6% Hemolysis | 32 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Peptidomic approach identifies cruzioseptins, a new family of potent antimicrobial peptides in the splendid leaf frog, Cruziohyla calcarifer. | J Proteomics | 2016
Evidence 7 Activity

Activity

24% Hemolysis
Toxicity
64 µg/mL
Hemolytic Cytotoxic
24% Hemolysis | 64 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Peptidomic approach identifies cruzioseptins, a new family of potent antimicrobial peptides in the splendid leaf frog, Cruziohyla calcarifer. | J Proteomics | 2016
Evidence 8 Activity

Activity

59% Hemolysis
Toxicity
128 µg/mL
Hemolytic Cytotoxic
59% Hemolysis | 128 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Peptidomic approach identifies cruzioseptins, a new family of potent antimicrobial peptides in the splendid leaf frog, Cruziohyla calcarifer. | J Proteomics | 2016
Evidence 9 Activity

Activity

83% Hemolysis
Toxicity
256 µg/mL
Hemolytic Cytotoxic
83% Hemolysis | 256 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Peptidomic approach identifies cruzioseptins, a new family of potent antimicrobial peptides in the splendid leaf frog, Cruziohyla calcarifer. | J Proteomics | 2016
Evidence 10 Activity

Activity

96% Hemolysis
Toxicity
512 µg/mL
Hemolytic Cytotoxic
96% Hemolysis | 512 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Peptidomic approach identifies cruzioseptins, a new family of potent antimicrobial peptides in the splendid leaf frog, Cruziohyla calcarifer. | J Proteomics | 2016
Evidence 11 Activity

Activity

50% Cytotoxicity
Toxicity
127.19±0.3 µM
Cytotoxic
50% Cytotoxicity | 127.19±0.3 | µM | target cell: Bone marrow-derived macrophages (BMDMs)

Target

Bone marrow-derived macrophages (BMDMs)

Source & Reference

NA
DBAASP
Cruzioseptins, antibacterial peptides from Cruziohyla calcarifer skin, as promising leishmanicidal agents. | Pathog Dis | 2020
Evidence 12 Hemolysis

Source & Reference

APD_complete PD_Hemolysis
APD_complete PD_Hemolysis

Other

Source Activity Label Source Definition
Hemolysis
APD_complete APD-derived hemolytic peptide annotation.