Back to search

Peptide record

TPDB10210

Antibacterial Antifungal Antiparasitic Hemolysis Toxicity standard
23 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB10210
Antibacterial Antifungal Antiparasitic Hemolysis Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia Antifungipept CAFPdb dbAMP 3.0 APD_complete PD_Hemolysis ToxinPred 3.0
standard
No
A 23-aa standard natural multi-activity (Antibacterial, Antifungal, Antiparasitic, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
GFLDVIKHVGKAALGVVTHLINQ
Physicochemical Analysis
C112H185N31O29
RCEMPSWY
V
2429.89
9.88
4
1
12
+1
2.81
0.739
143.91
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
0
0.00
3
Residue Composition
number
2
A
0
R
1
N
1
D
0
C
0
E
1
Q
3
G
2
H
2
I
3
L
2
K
0
M
1
F
0
P
0
S
1
T
0
W
0
Y
4
V
Amino Acid Distribution
A: 2 R: 0 N: 1 D: 1 C: 0 E: 0 Q: 1 G: 3 H: 2 I: 2 L: 3 K: 2 M: 0 F: 1 P: 0 S: 0 T: 1 W: 0 Y: 0 V: 4
Chemical Descriptors
23
C112H185N31O29
2429.89
9.88
+1
2.81
0.739
Evidence Records 12 records
Evidence 1 Activity

Activity

Antibacterial

Source & Reference

dbAMP DRAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class.
Active against E. coli (26.3 uM), S. aureus (6.6 uM), and C. albicans (13.2 uM). Updated 7/2021
Evidence 2 Activity

Activity

Antifungal

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class.
Active against E. coli (26.3 uM), S. aureus (6.6 uM), and C. albicans (13.2 uM). Updated 7/2021
Evidence 3 Activity

Activity

Antiparasitic

Source & Reference

dbAMP 3.0 DRAMP

Other

Source Activity Label Source Definition
Antiparasitic
dbAMP 3.0 classified under the Anti-parasitic function class.
Active against E. coli (26.3 uM), S. aureus (6.6 uM), and C. albicans (13.2 uM). Updated 7/2021
Evidence 4 Activity

Activity

1% Hemolysis
Toxicity
4-8 µg/mL
Hemolytic Cytotoxic
1% Hemolysis | 4-8 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Peptidomic approach identifies cruzioseptins, a new family of potent antimicrobial peptides in the splendid leaf frog, Cruziohyla calcarifer. | J Proteomics | 2016
Evidence 5 Activity

Activity

6% Hemolysis
Toxicity
16 µg/mL
Hemolytic Cytotoxic
6% Hemolysis | 16 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Peptidomic approach identifies cruzioseptins, a new family of potent antimicrobial peptides in the splendid leaf frog, Cruziohyla calcarifer. | J Proteomics | 2016
Evidence 6 Activity

Activity

26% Hemolysis
Toxicity
32 µg/mL
Hemolytic Cytotoxic
26% Hemolysis | 32 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Peptidomic approach identifies cruzioseptins, a new family of potent antimicrobial peptides in the splendid leaf frog, Cruziohyla calcarifer. | J Proteomics | 2016
Evidence 7 Activity

Activity

54% Hemolysis
Toxicity
64 µg/mL
Hemolytic Cytotoxic
54% Hemolysis | 64 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Peptidomic approach identifies cruzioseptins, a new family of potent antimicrobial peptides in the splendid leaf frog, Cruziohyla calcarifer. | J Proteomics | 2016
Evidence 8 Activity

Activity

75% Hemolysis
Toxicity
128 µg/mL
Hemolytic Cytotoxic
75% Hemolysis | 128 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Peptidomic approach identifies cruzioseptins, a new family of potent antimicrobial peptides in the splendid leaf frog, Cruziohyla calcarifer. | J Proteomics | 2016
Evidence 9 Activity

Activity

93% Hemolysis
Toxicity
256 µg/mL
Hemolytic Cytotoxic
93% Hemolysis | 256 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Peptidomic approach identifies cruzioseptins, a new family of potent antimicrobial peptides in the splendid leaf frog, Cruziohyla calcarifer. | J Proteomics | 2016
Evidence 10 Activity

Activity

100% Hemolysis
Toxicity
512 µg/mL
Hemolytic Cytotoxic
100% Hemolysis | 512 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Peptidomic approach identifies cruzioseptins, a new family of potent antimicrobial peptides in the splendid leaf frog, Cruziohyla calcarifer. | J Proteomics | 2016
Evidence 11 Activity

Activity

50% Cytotoxicity
Toxicity
119.82±1.4 µM
Cytotoxic
50% Cytotoxicity | 119.82±1.4 | µM | target cell: Bone marrow-derived macrophages (BMDMs)

Target

Bone marrow-derived macrophages (BMDMs)

Source & Reference

NA
DBAASP
Cruzioseptins, antibacterial peptides from Cruziohyla calcarifer skin, as promising leishmanicidal agents. | Pathog Dis | 2020
Evidence 12 Hemolysis

Source & Reference

APD_complete PD_Hemolysis
APD_complete PD_Hemolysis

Other

Source Activity Label Source Definition
Hemolysis
APD_complete APD-derived hemolytic peptide annotation.