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Peptide record

TPDB10204

Antibacterial Antifungal Toxicity standard
23 amino acids
Basic Information
3D PDB MODEL
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TPDB10204
Antibacterial Antifungal Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia AFP-GFuse Antifungipept CAFPdb
standard
No
A 23-aa standard-residue multi-activity (Antibacterial, Antifungal, and Toxicity) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
TWLPAVIKIQAHWRGYRQRKIYL
Physicochemical Analysis

Sequence-only estimates for a linear peptide with free termini, not experimentally measured molecular properties. Mass and formula exclude cyclization and disulfide formation. The optical estimates assume paired cysteines, 280 nm, 1 g/L and a 1 cm path. The N-end rule estimate is not a measured plasma half-life.

C138H214N40O29
NDCEMFS
RI
2897.47
11.45
6
0
12
+5
1.59
-0.422
106.09
Mammalian: 7.2 hour Yeast: >20 hour E.coli: >10 hour
13980
4.82
5
Residue Composition
number
2
A
3
R
0
N
0
D
0
C
0
E
2
Q
1
G
1
H
3
I
2
L
2
K
0
M
0
F
1
P
0
S
1
T
2
W
2
Y
1
V
Amino Acid Distribution
A: 2 R: 3 N: 0 D: 0 C: 0 E: 0 Q: 2 G: 1 H: 1 I: 3 L: 2 K: 2 M: 0 F: 0 P: 1 S: 0 T: 1 W: 2 Y: 2 V: 1
Chemical Descriptors
23 reviewed residue count
C138H214N40O29 sequence-only estimate (linear, free termini)
2897.47 sequence-only estimate (linear, free termini)
11.45 sequence-only estimate (linear, free termini)
+5 sequence-only estimate (linear, free termini)
1.59 sequence-only estimate (linear, free termini)
-0.422 sequence-only estimate (linear, free termini)
Evidence Records 2 records
Evidence 1 Activity

Activity

4% Hemolysis
Toxicity
100 µg/mL
Hemolytic Cytotoxic
4% Hemolysis | 100 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
IQ-motif peptides as novel anti-microbial agents. | Biochimie | 2013
Evidence 2 Activity

Activity

7% Hemolysis
Toxicity
200 µg/mL
Hemolytic Cytotoxic
7% Hemolysis | 200 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
IQ-motif peptides as novel anti-microbial agents. | Biochimie | 2013