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Peptide record

TPDB10199

Antibacterial Toxicity standard
23 amino acids
Basic Information
3D PDB MODEL
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TPDB10199
Antibacterial Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 dbAMP Peptipedia
standard
No
A 23-aa standard natural multi-activity (Antibacterial and Toxicity) peptide sequence curated from AntiBP3, dbAMP, and Peptipedia, with an available 3D structural model.
Sequence
GSKKPVPIIYCNRRAATGKCQRM
Physicochemical Analysis
C109H189N37O29S3
DEHLFW
RK
2578.11
10.88
6
0
7
+6
5.05
-0.665
55.22
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
1615
62.64
7
Residue Composition
number
2
A
3
R
1
N
0
D
2
C
0
E
1
Q
2
G
0
H
2
I
0
L
3
K
1
M
0
F
2
P
1
S
1
T
0
W
1
Y
1
V
Amino Acid Distribution
A: 2 R: 3 N: 1 D: 0 C: 2 E: 0 Q: 1 G: 2 H: 0 I: 2 L: 0 K: 3 M: 1 F: 0 P: 2 S: 1 T: 1 W: 0 Y: 1 V: 1
Chemical Descriptors
23
C109H189N37O29S3
2578.11
10.88
+6
5.05
-0.665
Evidence Records 5 records
Evidence 1 Activity

Activity

MIC
Antibacterial
2.6 µM

Target

Escherichia coli HB 101

Source & Reference

dbAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class.
active against E. coli HB 101 (MIC 2.6 uM), S. typhimurium (MIC 2.6 uM), P. aeruginosa (MIC 5.2-10.4 uM), B. subtilis (MIC 20.8 uM),
Evidence 2 Activity

Activity

MIC
Antibacterial
2.6 µM

Target

S. typhimurium

Source & Reference

dbAMP

Other

active against E. coli HB 101 (MIC 2.6 uM), S. typhimurium (MIC 2.6 uM), P. aeruginosa (MIC 5.2-10.4 uM), B. subtilis (MIC 20.8 uM), and S-aureus (MIC >20.8 uM).
Evidence 3 Activity

Activity

MIC
Antibacterial
5.2-10.4 µM

Target

Pseudomonas aeruginosa

Source & Reference

dbAMP

Other

active against E. coli HB 101 (MIC 2.6 uM), S. typhimurium (MIC 2.6 uM), P. aeruginosa (MIC 5.2-10.4 uM), B. subtilis (MIC 20.8 uM), and S-aureus (MIC >20.8 uM).
Evidence 4 Activity

Activity

MIC
Antibacterial
20.8 µM

Target

B. subtilis

Source & Reference

dbAMP

Other

. coli HB 101 (MIC 2.6 uM), S. typhimurium (MIC 2.6 uM), P. aeruginosa (MIC 5.2-10.4 uM), B. subtilis (MIC 20.8 uM), and S-aureus (MIC >20.8 uM).
Evidence 5 Activity

Activity

0% Hemolysis
Toxicity
200 µg/mL
Hemolytic Cytotoxic
0% Hemolysis | 200 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Role of amino acid residues within the disulfide loop of thanatin, a potent antibiotic peptide. | J Biochem Mol Biol | 2002