Back to search

Peptide record

TPDB10198

Antibacterial Antifungal Antiparasitic Toxicity standard
23 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB10198
Antibacterial Antifungal Antiparasitic Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 DRAMP Peptipedia AFP-GFuse Antifungipept CAFPdb dbAMP dbAMP 3.0 i2APP
standard
No
A 23-aa standard natural multi-activity (Antibacterial, Antifungal, Antiparasitic, and other sources) peptide sequence curated from AntiBP3, DRAMP, Peptipedia, and other sources, with an available 3D structural model.
Sequence
GLKEVAHSAKKFAKGFISGLTGS
Physicochemical Analysis
C106H173N29O30
RNDCQMPWY
GK
2333.72
10.55
5
1
9
+3
3.38
0.013
76.52
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
0
0.00
4
Residue Composition
number
3
A
0
R
0
N
0
D
0
C
1
E
0
Q
4
G
1
H
1
I
2
L
4
K
0
M
2
F
0
P
3
S
1
T
0
W
0
Y
1
V
Amino Acid Distribution
A: 3 R: 0 N: 0 D: 0 C: 0 E: 1 Q: 0 G: 4 H: 1 I: 1 L: 2 K: 4 M: 0 F: 2 P: 0 S: 3 T: 1 W: 0 Y: 0 V: 1
Chemical Descriptors
23
C106H173N29O30
2333.72
10.55
+3
3.38
0.013
Evidence Records 19 records
Evidence 1 Activity

Activity

MIC
Antibacterial
64 µM

Target

Escherichia coli

Source & Reference

dbAMP DRAMP

Other

Source Activity Label Source Definition
Antibacterial
DRAMP antibacterial activity supported by MIC records against bacterial target organisms. dbAMP classified as Antibacterial under the Anti-bacterial function class.
Active against Gram- E. coli (MIC 64 uM), P.aeruginosa (MIC >256 uM), Gram+ S.aureus (MIC >256 uM), M. luteus (MIC 32 uM), yeast S
Evidence 2 Activity

Activity

MIC
Antibacterial
>256 µM

Target

P.aeruginosa

Source & Reference

dbAMP DRAMP

Other

Active against Gram- E. coli (MIC 64 uM), P.aeruginosa (MIC >256 uM), Gram+ S.aureus (MIC >256 uM), M. luteus (MIC 32 uM), yeast S.cerevisiae (MIC 128 uM), an
Evidence 3 Activity

Activity

MIC
Antibacterial
>256 µM

Target

S.aureus

Source & Reference

dbAMP DRAMP

Other

Active against Gram- E. coli (MIC 64 uM), P.aeruginosa (MIC >256 uM), Gram+ S.aureus (MIC >256 uM), M. luteus (MIC 32 uM), yeast S.cerevisiae (MIC 128 uM), and parasite T. brucei (LC95 8-
Evidence 4 Activity

Activity

MIC
Antibacterial
32 µM

Target

M. luteus

Source & Reference

dbAMP DRAMP

Other

inst Gram- E. coli (MIC 64 uM), P.aeruginosa (MIC >256 uM), Gram+ S.aureus (MIC >256 uM), M. luteus (MIC 32 uM), yeast S.cerevisiae (MIC 128 uM), and parasite T. brucei (LC95 8- >256 uM).
Evidence 5 Activity

Activity

MIC
Antibacterial
128 µM

Target

S.cerevisiae

Source & Reference

dbAMP DRAMP

Other

), P.aeruginosa (MIC >256 uM), Gram+ S.aureus (MIC >256 uM), M. luteus (MIC 32 uM), yeast S.cerevisiae (MIC 128 uM), and parasite T. brucei (LC95 8- >256 uM).
Evidence 6 Activity

Activity

MIC
Antifungal
64 µM

Target

Escherichia coli

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Source Activity Label Source Definition
Antifungal
DRAMP antifungal activity supported by activity records against fungal target organisms. dbAMP classified under the Anti-fungal function class.
Active against Gram- E. coli (MIC 64 uM), P.aeruginosa (MIC >256 uM), Gram+ S.aureus (MIC >256 uM), M. luteus (MIC 32 uM), yeast S
Evidence 7 Activity

Activity

MIC
Antifungal
>256 µM

Target

P.aeruginosa

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Active against Gram- E. coli (MIC 64 uM), P.aeruginosa (MIC >256 uM), Gram+ S.aureus (MIC >256 uM), M. luteus (MIC 32 uM), yeast S.cerevisiae (MIC 128 uM), an
Evidence 8 Activity

Activity

MIC
Antifungal
>256 µM

Target

S.aureus

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Active against Gram- E. coli (MIC 64 uM), P.aeruginosa (MIC >256 uM), Gram+ S.aureus (MIC >256 uM), M. luteus (MIC 32 uM), yeast S.cerevisiae (MIC 128 uM), and parasite T. brucei (LC95 8-
Evidence 9 Activity

Activity

MIC
Antifungal
32 µM

Target

M. luteus

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

inst Gram- E. coli (MIC 64 uM), P.aeruginosa (MIC >256 uM), Gram+ S.aureus (MIC >256 uM), M. luteus (MIC 32 uM), yeast S.cerevisiae (MIC 128 uM), and parasite T. brucei (LC95 8- >256 uM).
Evidence 10 Activity

Activity

MIC
Antifungal
128 µM

Target

S.cerevisiae

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

), P.aeruginosa (MIC >256 uM), Gram+ S.aureus (MIC >256 uM), M. luteus (MIC 32 uM), yeast S.cerevisiae (MIC 128 uM), and parasite T. brucei (LC95 8- >256 uM).
Evidence 11 Activity

Activity

MIC
Antiparasitic
64 µM

Target

Escherichia coli

Source & Reference

dbAMP 3.0 DRAMP

Other

Source Activity Label Source Definition
Antiparasitic
DRAMP antiparasitic activity supported by activity records against parasitic targets. dbAMP 3.0 classified under the Anti-parasitic function class.
Active against Gram- E. coli (MIC 64 uM), P.aeruginosa (MIC >256 uM), Gram+ S.aureus (MIC >256 uM), M. luteus (MIC 32 uM), yeast S
Evidence 12 Activity

Activity

MIC
Antiparasitic
>256 µM

Target

P.aeruginosa

Source & Reference

dbAMP 3.0 DRAMP

Other

Active against Gram- E. coli (MIC 64 uM), P.aeruginosa (MIC >256 uM), Gram+ S.aureus (MIC >256 uM), M. luteus (MIC 32 uM), yeast S.cerevisiae (MIC 128 uM), an
Evidence 13 Activity

Activity

MIC
Antiparasitic
>256 µM

Target

S.aureus

Source & Reference

dbAMP 3.0 DRAMP

Other

Active against Gram- E. coli (MIC 64 uM), P.aeruginosa (MIC >256 uM), Gram+ S.aureus (MIC >256 uM), M. luteus (MIC 32 uM), yeast S.cerevisiae (MIC 128 uM), and parasite T. brucei (LC95 8-
Evidence 14 Activity

Activity

MIC
Antiparasitic
32 µM

Target

M. luteus

Source & Reference

dbAMP 3.0 DRAMP

Other

inst Gram- E. coli (MIC 64 uM), P.aeruginosa (MIC >256 uM), Gram+ S.aureus (MIC >256 uM), M. luteus (MIC 32 uM), yeast S.cerevisiae (MIC 128 uM), and parasite T. brucei (LC95 8- >256 uM).
Evidence 15 Activity

Activity

MIC
Antiparasitic
128 µM

Target

S.cerevisiae

Source & Reference

dbAMP 3.0 DRAMP

Other

), P.aeruginosa (MIC >256 uM), Gram+ S.aureus (MIC >256 uM), M. luteus (MIC 32 uM), yeast S.cerevisiae (MIC 128 uM), and parasite T. brucei (LC95 8- >256 uM).
Evidence 16 Activity

Activity

50% Hemolysis
Toxicity
>256 µM
Hemolytic Cytotoxic
50% Hemolysis | >256 | µM | target cell: Mouse erythrocytes

Target

Mouse erythrocytes

Source & Reference

NA
DBAASP
Origin and functional diversification of an amphibian defense peptide arsenal. | PLoS Genet | 2013
Evidence 17 Activity

Activity

IC50
Toxicity
>256 µM
Cytotoxic
IC50 | >256 | µM | target cell: Mouse splenocytes

Target

Mouse splenocytes

Source & Reference

NA
DBAASP
Origin and functional diversification of an amphibian defense peptide arsenal. | PLoS Genet | 2013
Evidence 18 Activity

Activity

0% Hemolysis
Toxicity
20 µM
Hemolytic Cytotoxic
0% Hemolysis | 20 | µM | target cell: Rat erythrocytes

Target

Rat erythrocytes

Source & Reference

NA
DBAASP
Identification of novel peptides from amphibian (Xenopus tropicalis) skin by direct tissue MALDI-MS analysis. | FEBS J | 2015
Evidence 19 Activity

Activity

HC50
Toxicity
256 µm
Hemolytic Cytotoxic
Hemolytic_activity: [Ref.25312021]0.2% Hemolysis against Rat erythrocytes at 20 µM.##[Ref.23935531] Hemolysis against Mouse erythrocytes (HC50>256 µm). | Cytotoxicity: [Ref.23935531]Cytotoxicity against T-lymphocytes(IC50>256 µM).

Target

erythrocytes

Source & Reference

NA
DRAMP
FEBS J. 2015 Jan 282(1):102-13.##PLoS Genet. 2013 9(8):e1003662.