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Peptide record

TPDB10188

Antibacterial Anticancer Antifungal Antiviral Hemolysis Toxicity standard
23 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB10188
Antibacterial Anticancer Antifungal Antiviral Hemolysis Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 dbAMP Peptipedia dbACP Antifungipept CAFPdb AI4AVP AVPpred-BWR dbAMP 3.0 DRAVP 2.0 APD_complete APD_hemolytic PD_Hemolysis ToxinPred 3.0
standard
No
A 23-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, Peptipedia, and other sources, with an available 3D structural model.
Sequence
FIHHIIGGLFSVGKHIHSLIHGH
Physicochemical Analysis
C121H182N36O26
ARNDCEQMPTWY
H
2557.00
10.10
7
0
10
+2
2.19
0.591
131.30
Mammalian: 1.1 hour Yeast: 3 min E.coli: 2 min
0
0.00
2
Residue Composition
number
0
A
0
R
0
N
0
D
0
C
0
E
0
Q
4
G
6
H
5
I
2
L
1
K
0
M
2
F
0
P
2
S
0
T
0
W
0
Y
1
V
Amino Acid Distribution
A: 0 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 4 H: 6 I: 5 L: 2 K: 1 M: 0 F: 2 P: 0 S: 2 T: 0 W: 0 Y: 0 V: 1
Chemical Descriptors
23
C121H182N36O26
2557.00
10.10
+2
2.19
0.591
Evidence Records 20 records
Evidence 1 Activity

Activity

MIC
Antibacterial
2.44 µg/mL

Target

V. vulnificus 204

Source & Reference

dbAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class.
Active against Gram-negative V. vulnificus 204 (MIC 2.44 ug/ml), A-hydrophila BCRC 13018 (MIC>19.55 ug/ml), V. alginolyticus (MIC 2.44 ug/ml), P-aerugino
Evidence 2 Activity

Activity

MIC
Antibacterial
2.44 µg/mL

Target

V. alginolyticus

Source & Reference

dbAMP

Other

m-negative V. vulnificus 204 (MIC 2.44 ug/ml), A-hydrophila BCRC 13018 (MIC>19.55 ug/ml), V. alginolyticus (MIC 2.44 ug/ml), P-aeruginosa ATCC 19660 (MIC>19.55ug/ml), Gram-positive bacteria S. agalactiae 819 (MIC
Evidence 3 Activity

Activity

MIC
Antibacterial
9.78 µg/mL

Target

Streptococcus agalactiae 819

Source & Reference

dbAMP

Other

yticus (MIC 2.44 ug/ml), P-aeruginosa ATCC 19660 (MIC>19.55ug/ml), Gram-positive bacteria S. agalactiae 819 (MIC 9.78 ug/ml), E. faecalis BCRC 10066 (MIC 19.55 ug/ml), and S. agalactiae BCRC 10787 (MIC: 0.61 ug/ml)
Evidence 4 Activity

Activity

MIC
Antibacterial
19.55 µg/mL

Target

Enterococcus faecalis BCRC 10066

Source & Reference

dbAMP

Other

a ATCC 19660 (MIC>19.55ug/ml), Gram-positive bacteria S. agalactiae 819 (MIC 9.78 ug/ml), E. faecalis BCRC 10066 (MIC 19.55 ug/ml), and S. agalactiae BCRC 10787 (MIC: 0.61 ug/ml).
Evidence 5 Activity

Activity

MIC
Antifungal
2.44 µg/mL

Target

V. vulnificus 204

Source & Reference

dbAMP CAFPdb Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class.
Active against Gram-negative V. vulnificus 204 (MIC 2.44 ug/ml), A-hydrophila BCRC 13018 (MIC>19.55 ug/ml), V. alginolyticus (MIC 2.44 ug/ml), P-aerugino
Evidence 6 Activity

Activity

MIC
Antifungal
2.44 µg/mL

Target

V. alginolyticus

Source & Reference

dbAMP CAFPdb Antifungipept

Other

m-negative V. vulnificus 204 (MIC 2.44 ug/ml), A-hydrophila BCRC 13018 (MIC>19.55 ug/ml), V. alginolyticus (MIC 2.44 ug/ml), P-aeruginosa ATCC 19660 (MIC>19.55ug/ml), Gram-positive bacteria S. agalactiae 819 (MIC
Evidence 7 Activity

Activity

MIC
Antifungal
9.78 µg/mL

Target

Streptococcus agalactiae 819

Source & Reference

dbAMP CAFPdb Antifungipept

Other

yticus (MIC 2.44 ug/ml), P-aeruginosa ATCC 19660 (MIC>19.55ug/ml), Gram-positive bacteria S. agalactiae 819 (MIC 9.78 ug/ml), E. faecalis BCRC 10066 (MIC 19.55 ug/ml), and S. agalactiae BCRC 10787 (MIC: 0.61 ug/ml)
Evidence 8 Activity

Activity

MIC
Antifungal
19.55 µg/mL

Target

Enterococcus faecalis BCRC 10066

Source & Reference

dbAMP CAFPdb Antifungipept

Other

a ATCC 19660 (MIC>19.55ug/ml), Gram-positive bacteria S. agalactiae 819 (MIC 9.78 ug/ml), E. faecalis BCRC 10066 (MIC 19.55 ug/ml), and S. agalactiae BCRC 10787 (MIC: 0.61 ug/ml).
Evidence 9 Activity

Activity

MIC
Antiviral
2.44 µg/mL

Target

V. vulnificus 204

Source & Reference

dbAMP 3.0 DRAVP 2.0

Other

Source Activity Label Source Definition
Antiviral
dbAMP 3.0 classified under the Anti-viral function class.
Active against Gram-negative V. vulnificus 204 (MIC 2.44 ug/ml), A-hydrophila BCRC 13018 (MIC>19.55 ug/ml), V. alginolyticus (MIC 2.44 ug/ml), P-aerugino
Evidence 10 Activity

Activity

MIC
Antiviral
2.44 µg/mL

Target

V. alginolyticus

Source & Reference

dbAMP 3.0 DRAVP 2.0

Other

m-negative V. vulnificus 204 (MIC 2.44 ug/ml), A-hydrophila BCRC 13018 (MIC>19.55 ug/ml), V. alginolyticus (MIC 2.44 ug/ml), P-aeruginosa ATCC 19660 (MIC>19.55ug/ml), Gram-positive bacteria S. agalactiae 819 (MIC
Evidence 11 Activity

Activity

MIC
Antiviral
9.78 µg/mL

Target

Streptococcus agalactiae 819

Source & Reference

dbAMP 3.0 DRAVP 2.0

Other

yticus (MIC 2.44 ug/ml), P-aeruginosa ATCC 19660 (MIC>19.55ug/ml), Gram-positive bacteria S. agalactiae 819 (MIC 9.78 ug/ml), E. faecalis BCRC 10066 (MIC 19.55 ug/ml), and S. agalactiae BCRC 10787 (MIC: 0.61 ug/ml)
Evidence 12 Activity

Activity

MIC
Antiviral
19.55 µg/mL

Target

Enterococcus faecalis BCRC 10066

Source & Reference

dbAMP 3.0 DRAVP 2.0

Other

a ATCC 19660 (MIC>19.55ug/ml), Gram-positive bacteria S. agalactiae 819 (MIC 9.78 ug/ml), E. faecalis BCRC 10066 (MIC 19.55 ug/ml), and S. agalactiae BCRC 10787 (MIC: 0.61 ug/ml).
Evidence 13 Activity

Activity

50% Hemolysis
Toxicity
25 µg/mL
Hemolytic Cytotoxic
50% Hemolysis | 25 | µg/mL | target cell: Mouse erythrocytes

Target

Mouse erythrocytes

Source & Reference

NA
DBAASP
Hydrophobic residues are critical for the helix-forming, hemolytic and bactericidal activities of amphipathic antimicrobial peptide TP4. | PLoS One | 2017
Evidence 14 Activity

Activity

42% Hemolysis
Toxicity
100 µg/mL
Hemolytic Cytotoxic
42% Hemolysis | 100 | µg/mL | target cell: Tilapia erythrocytes

Target

Tilapia erythrocytes

Source & Reference

NA
DBAASP
Five different piscidins from Nile tilapia, Oreochromis niloticus: analysis of their expressions and biological functions. | PLoS One | 2012
Evidence 15 Activity

Activity

100% Hemolysis
Toxicity
25 µg/mL
Hemolytic Cytotoxic
100% Hemolysis | 25 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Five different piscidins from Nile tilapia, Oreochromis niloticus: analysis of their expressions and biological functions. | PLoS One | 2012
Evidence 16 Activity

Activity

50% Cell death
Toxicity
80 µg/mL
Cytotoxic
50% Cell death | 80 | µg/mL | target cell: Tilapia ovary TO2 cells

Target

Tilapia ovary TO2 cells

Source & Reference

NA
DBAASP
Five different piscidins from Nile tilapia, Oreochromis niloticus: analysis of their expressions and biological functions. | PLoS One | 2012
Evidence 17 Activity

Activity

20% Cell death
Toxicity
40 µg/mL
Cytotoxic
20% Cell death | 40 | µg/mL | target cell: Human fibroblasts MRC-5

Target

Human fibroblasts MRC-5

Source & Reference

NA
DBAASP
Five different piscidins from Nile tilapia, Oreochromis niloticus: analysis of their expressions and biological functions. | PLoS One | 2012
Evidence 18 Activity

Activity

50% Cytotoxicity
Toxicity
39.0±1.2 µg/mL
Cytotoxic
50% Cytotoxicity | 39.0±1.2 | µg/mL | target cell: Baby Hamster Kidney cells BHK-21

Target

Baby Hamster Kidney cells BHK-21

Source & Reference

NA
DBAASP
Grouper (Epinephelus coioides) antimicrobial peptide epinecidin-1 exhibits antiviral activity against foot-and-mouth disease virus in vitro. | Peptides | 2018
Evidence 19 Activity

Activity

Toxicity
Cytotoxic
Cytotoxicity: [Ref.30012343]Baby Hamster Kidney cells BHK-21:CC50=39.0±1.2 µg/ml.

Source & Reference

NA
DRAMP
Peptides. 2018 Aug 106:91-95.
Evidence 20 Hemolysis

Source & Reference

APD_complete APD_hemolytic PD_Hemolysis
APD_complete APD_hemolytic PD_Hemolysis

Other

Source Activity Label Source Definition
Hemolysis
APD_complete APD-derived hemolytic peptide annotation. APD_hemolytic APD hemolytic peptide annotation.