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Peptide record

TPDB10178

Antibacterial Anticancer Hemolysis Toxicity standard
23 amino acids
Basic Information
3D PDB MODEL
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TPDB10178
Antibacterial Anticancer Hemolysis Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 Peptipedia HemoPI Hemolytic2 PD_Hemolysis ToxinPred 3.0
standard
No
A 23-aa standard natural multi-activity (Antibacterial, Anticancer, Hemolysis, and other sources) peptide sequence curated from AntiBP3, Peptipedia, HemoPI, and other sources, with an available 3D structural model.
Sequence
KILRGVSKKIMRTFLRRILTGKK
Physicochemical Analysis
C124H228N40O27S1
ANDCEQHPWY
K
2743.49
12.89
9
0
9
+9
4.72
-0.291
114.35
Mammalian: 1.3 hour Yeast: 3 min E.coli: 2 min
0
0.00
3
Residue Composition
number
0
A
4
R
0
N
0
D
0
C
0
E
0
Q
2
G
0
H
3
I
3
L
5
K
1
M
1
F
0
P
1
S
2
T
0
W
0
Y
1
V
Amino Acid Distribution
A: 0 R: 4 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 2 H: 0 I: 3 L: 3 K: 5 M: 1 F: 1 P: 0 S: 1 T: 2 W: 0 Y: 0 V: 1
Chemical Descriptors
23
C124H228N40O27S1
2743.49
12.89
+9
4.72
-0.291
Evidence Records 4 records
Evidence 1 Activity

Activity

% Hemolysis
Hemolysis
15 %
Human erythrocytes: 15% Hemolysis=100 µg/ml

Target

Human erythrocytes

Source & Reference

Hemolytik PD_Hemolysis
DRAMP4
J Biol Chem. 2007 May 18 282(20):14719-28.

Other

Source Activity Label Source Definition
Hemolysis
Hemolytik experimentally validated hemolytic peptide annotation.
Evidence 2 Activity

Activity

15% Hemolysis
Toxicity
100 µg/mL
Hemolytic Cytotoxic
15% Hemolysis | 100 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Rationale for the design of shortened derivatives of the NK-lysin-derived antimicrobial peptide NK-2 with improved activity against Gram-negative pathogens. | J Biol Chem | 2007
Evidence 3 Activity

Activity

% Hemolysis
Toxicity
15 %
Hemolytic Cytotoxic
Hemolytic_activity: Human erythrocytes: 15% Hemolysis=100 µg/ml | Cytotoxicity: Not available

Target

erythrocytes

Source & Reference

NA
DRAMP
J Biol Chem. 2007 May 18 282(20):14719-28.
Evidence 4 Hemolysis

Activity

15 %
% Hemolysis
Human erythrocytes: 15% Hemolysis=100 µg/ml
Hemolysis

Target

Human erythrocytes

Source & Reference

HemoPI PD_Hemolysis
J Biol Chem. 2007 May 18 282(20):14719-28.
DRAMP4
PD_Hemolysis