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Peptide record

TPDB10177

Antibacterial Antifungal Antiparasitic Hemolysis Toxicity standard

23 amino acids

3D PDB MODEL

Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.

TPDB ID TPDB10177

Activity

Antibacterial Antifungal Antiparasitic Hemolysis Toxicity

Activity_category_statistics

Anti-infective peptides Toxicity and safety peptides

Database_Source

AntiBP3 Peptipedia AFP-GFuse Antifungipept CAFPdb dbAMP dbAMP 3.0 i2APP APD_complete PD_Hemolysis

Sequence_Type

standard

Has_Modification No

Description A 23-aa standard natural multi-activity (Antibacterial, Antifungal, Antiparasitic, and other sources) peptide sequence curated from AntiBP3, Peptipedia, AFP-GFuse, and other sources, with an available 3D structural model.

Sequence

IFGLLLHGAIHVGKLIHGLVRRH

FASTA

>TPDB10177|Antibacterial;Antifungal;Antiparasitic;Hemolysis;Toxicity|length=23
IFGLLLHGAIHVGKLIHGLVRRH

Formula C120H198N38O24

Absent Amino Acids NDCEQMPSTWY

Common Amino Acids L

Mass 2557.13

PI 12.41

Basic Residues 7

Acidic Residues 0

Hydrophobic Residues 12

Net Charge +3

Boman Index 1.60

Hydrophobicity 0.791

Aliphatic Index 165.22

Half Life

Mammalian: 20 hour Yeast: 30 min E.coli: >10 hour

Extinction Coefficient Cystines 0

Absorbance 280nm 0.00

Polar Residues 0

number

Amino Acid Distribution

A: 1 R: 2 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 4 H: 4 I: 3 L: 5 K: 1 M: 0 F: 1 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 2

Length

Formula

C120H198N38O24

Mass

2557.13

12.41

Net Charge

Boman Index

1.60

Hydrophobicity

0.791

Evidence 1 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 2.5-5 µM

Target

Target Organism P. pastoris

Source & Reference

Database Source dbAMP

Other

Source Activity Label	Source Definition
Antibacterial	dbAMP classified as Antibacterial under the Anti-bacterial function class.

Evidence Text

Active against E. coli, S. aureus (MIC 10-20), V. parahaemolyticus, and P. pastoris (MIC 2.5-5 uM). Remarkably, it is also active against fish parasite C. irritans in the infective stage (

Evidence 2 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 2.5-5 µM

Target

Target Organism P. pastoris

Source & Reference

Database Source dbAMP CAFPdb Antifungipept

Other

Source Activity Label	Source Definition
Antifungal	dbAMP classified under the Anti-fungal function class.

Evidence Text

Active against E. coli, S. aureus (MIC 10-20), V. parahaemolyticus, and P. pastoris (MIC 2.5-5 uM). Remarkably, it is also active against fish parasite C. irritans in the infective stage (

Evidence 3 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 2.5-5 µM

Target

Target Organism P. pastoris

Source & Reference

Database Source dbAMP 3.0

Other

Source Activity Label	Source Definition
Antiparasitic	dbAMP 3.0 classified under the Anti-parasitic function class.

Evidence Text

Active against E. coli, S. aureus (MIC 10-20), V. parahaemolyticus, and P. pastoris (MIC 2.5-5 uM). Remarkably, it is also active against fish parasite C. irritans in the infective stage (

Evidence 4 Activity

Activity

Activity Endpoint 0.22±0.06% Hemolysis

Detail Source Activity Toxicity

Activity Measurement 1.25 µM

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

0.22±0.06% Hemolysis | 1.25 | µM | target cell: Rabbit erythrocytes

Target

Target Cell Rabbit erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Three new piscidins from orange-spotted grouper (Epinephelus coioides): Phylogeny, expression and functional characterization. | Fish Shellfish Immunol | 2017

Evidence 5 Activity

Activity

Activity Endpoint 8.05±0.33% Hemolysis

Detail Source Activity Toxicity

Activity Measurement 2.5 µM

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

8.05±0.33% Hemolysis | 2.5 | µM | target cell: Rabbit erythrocytes

Target

Target Cell Rabbit erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Three new piscidins from orange-spotted grouper (Epinephelus coioides): Phylogeny, expression and functional characterization. | Fish Shellfish Immunol | 2017

Evidence 6 Activity

Activity

Activity Endpoint 30.48±1.86% Hemolysis

Detail Source Activity Toxicity

Activity Measurement 5 µM

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

30.48±1.86% Hemolysis | 5 | µM | target cell: Rabbit erythrocytes

Target

Target Cell Rabbit erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Three new piscidins from orange-spotted grouper (Epinephelus coioides): Phylogeny, expression and functional characterization. | Fish Shellfish Immunol | 2017

Evidence 7 Activity

Activity

Activity Endpoint 38.99±0.97% Hemolysis

Detail Source Activity Toxicity

Activity Measurement 10 µM

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

38.99±0.97% Hemolysis | 10 | µM | target cell: Rabbit erythrocytes

Target

Target Cell Rabbit erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Three new piscidins from orange-spotted grouper (Epinephelus coioides): Phylogeny, expression and functional characterization. | Fish Shellfish Immunol | 2017

Evidence 8 Activity

Activity

Activity Endpoint 50.84±1.38% Hemolysis

Detail Source Activity Toxicity

Activity Measurement 20 µM

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

50.84±1.38% Hemolysis | 20 | µM | target cell: Rabbit erythrocytes

Target

Target Cell Rabbit erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Three new piscidins from orange-spotted grouper (Epinephelus coioides): Phylogeny, expression and functional characterization. | Fish Shellfish Immunol | 2017

Evidence 9 Hemolysis

Source & Reference

source APD_complete PD_Hemolysis

Database Source APD_complete PD_Hemolysis

Other

Source Activity Label	Source Definition
Hemolysis	APD_complete APD-derived hemolytic peptide annotation.