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Peptide record

TPDB10167

Antibacterial Hemolysis Toxicity standard
23 amino acids
Basic Information
3D PDB MODEL
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TPDB10167
Antibacterial Hemolysis Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 dbAMP Peptipedia HemoPI Hemolytic2 PD_Hemolysis
standard
No
A 23-aa standard natural multi-activity (Antibacterial, Hemolysis, and Toxicity) peptide sequence curated from AntiBP3, dbAMP, Peptipedia, and other sources, with an available 3D structural model.
Sequence
GIGKFIHAAKKFGKLFIGEIMNS
Physicochemical Analysis
C118H188N30O28S1
RDCQPTWYV
GIK
2507.03
10.55
5
1
11
+3
1.77
0.326
93.48
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
0
0.00
2
Residue Composition
number
2
A
0
R
1
N
0
D
0
C
1
E
0
Q
4
G
1
H
4
I
1
L
4
K
1
M
3
F
0
P
1
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 2 R: 0 N: 1 D: 0 C: 0 E: 1 Q: 0 G: 4 H: 1 I: 4 L: 1 K: 4 M: 1 F: 3 P: 0 S: 1 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
23
C118H188N30O28S1
2507.03
10.55
+3
1.77
0.326
Evidence Records 3 records
Evidence 1 Activity

Activity

50% Hemolysis
Toxicity
32 µM
Hemolytic Cytotoxic
50% Hemolysis | 32 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Hydrophobicity, hydrophobic moment and angle subtended by charged residues modulate antibacterial and haemolytic activity of amphipathic helical peptides | FEBS Lett | 1997
Evidence 2 Activity

Activity

98% Hemolysis
Toxicity
150 µM
Hemolytic Cytotoxic
98% Hemolysis | 150 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Peptide hydrophobicity controls the activity and selectivity of magainin 2 amide in interaction with membranes. | Biochemistry | 1997
Evidence 3 Hemolysis

Source & Reference

HemoPI PD_Hemolysis
PD_Hemolysis