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Peptide record

TPDB10159

Antibacterial Anticancer Antifungal Toxicity standard
23 amino acids
Basic Information
3D PDB MODEL
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TPDB10159
Antibacterial Anticancer Antifungal Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 Peptipedia dbACP CAFPdb dbAMP ToxinPred 3.0
standard
No
A 23-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, Peptipedia, dbACP, and other sources, with an available 3D structural model.
Sequence
ALWKEVLKNAGKAALNEINNLVQ
Physicochemical Analysis
C114H190N32O33
RDCHMFPSTY
ANL
2536.96
9.76
3
2
12
+1
4.34
-0.096
127.39
Mammalian: 4.4 hour Yeast: >20 hour E.coli: >10 hour
5500
216.80
5
Residue Composition
number
4
A
0
R
4
N
0
D
0
C
2
E
1
Q
1
G
0
H
1
I
4
L
3
K
0
M
0
F
0
P
0
S
0
T
1
W
0
Y
2
V
Amino Acid Distribution
A: 4 R: 0 N: 4 D: 0 C: 0 E: 2 Q: 1 G: 1 H: 0 I: 1 L: 4 K: 3 M: 0 F: 0 P: 0 S: 0 T: 0 W: 1 Y: 0 V: 2
Chemical Descriptors
23
C114H190N32O33
2536.96
9.76
+1
4.34
-0.096
Evidence Records 7 records
Evidence 1 Activity

Activity

IC50
Toxicity
4.85 µM
Cytotoxic
IC50 | 4.85 | µM | target cell: Human microvascular endothelial cells HMEC-1

Target

Human microvascular endothelial cells HMEC-1

Source & Reference

NA
DBAASP
Dermaseptin-PH: A Novel Peptide with Antimicrobial and Anticancer Activities from the Skin Secretion of the South American Orange-Legged Leaf Frog, Pithecopus (Phyllomedusa) hypochondrialis. | Molecules | 2017
Evidence 2 Activity

Activity

1% Hemolysis
Toxicity
16 µM
Hemolytic Cytotoxic
1% Hemolysis | 16 | µM | target cell: Horse erythrocytes

Target

Horse erythrocytes

Source & Reference

NA
DBAASP
Dermaseptin-PH: A Novel Peptide with Antimicrobial and Anticancer Activities from the Skin Secretion of the South American Orange-Legged Leaf Frog, Pithecopus (Phyllomedusa) hypochondrialis. | Molecules | 2017
Evidence 3 Activity

Activity

3% Hemolysis
Toxicity
64 µM
Hemolytic Cytotoxic
3% Hemolysis | 64 | µM | target cell: Horse erythrocytes

Target

Horse erythrocytes

Source & Reference

NA
DBAASP
Dermaseptin-PH: A Novel Peptide with Antimicrobial and Anticancer Activities from the Skin Secretion of the South American Orange-Legged Leaf Frog, Pithecopus (Phyllomedusa) hypochondrialis. | Molecules | 2017
Evidence 4 Activity

Activity

10% Hemolysis
Toxicity
128 µM
Hemolytic Cytotoxic
10% Hemolysis | 128 | µM | target cell: Horse erythrocytes

Target

Horse erythrocytes

Source & Reference

NA
DBAASP
Dermaseptin-PH: A Novel Peptide with Antimicrobial and Anticancer Activities from the Skin Secretion of the South American Orange-Legged Leaf Frog, Pithecopus (Phyllomedusa) hypochondrialis. | Molecules | 2017
Evidence 5 Activity

Activity

45% Hemolysis
Toxicity
256 µM
Hemolytic Cytotoxic
45% Hemolysis | 256 | µM | target cell: Horse erythrocytes

Target

Horse erythrocytes

Source & Reference

NA
DBAASP
Dermaseptin-PH: A Novel Peptide with Antimicrobial and Anticancer Activities from the Skin Secretion of the South American Orange-Legged Leaf Frog, Pithecopus (Phyllomedusa) hypochondrialis. | Molecules | 2017
Evidence 6 Activity

Activity

100% Hemolysis
Toxicity
512 µM
Hemolytic Cytotoxic
100% Hemolysis | 512 | µM | target cell: Horse erythrocytes

Target

Horse erythrocytes

Source & Reference

NA
DBAASP
Dermaseptin-PH: A Novel Peptide with Antimicrobial and Anticancer Activities from the Skin Secretion of the South American Orange-Legged Leaf Frog, Pithecopus (Phyllomedusa) hypochondrialis. | Molecules | 2017
Evidence 7 Activity

Activity

IC50
Toxicity
4.85 µM
Hemolytic Cytotoxic
Hemolytic_activity: Horse erythrocytes: 1% Hemolysis=16µM 3% Hemolysis=64µM 10% Hemolysis=128µM 45% Hemolysis=256µM 100% Hemolysis=512µM | Cytotoxicity: HMEC-1: IC50=4.85µM

Target

erythrocytes

Source & Reference

NA
DRAMP
Molecules. 2017 Oct 24 22(10):1805.