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Peptide record

TPDB10159

Antibacterial Anticancer Antifungal Toxicity standard
23 amino acids
Basic Information
3D PDB MODEL
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TPDB10159
Antibacterial Anticancer Antifungal Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 Peptipedia dbACP CAFPdb dbAMP ToxinPred 3.0
standard
No
A 23-aa standard-residue multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, Peptipedia, dbACP, and other sources, with an available 3D structural model.
Sequence
ALWKEVLKNAGKAALNEINNLVQ
Physicochemical Analysis

Sequence-only estimates for a linear peptide with free termini, not experimentally measured molecular properties. Mass and formula exclude cyclization and disulfide formation. The optical estimates assume paired cysteines, 280 nm, 1 g/L and a 1 cm path. The N-end rule estimate is not a measured plasma half-life.

C114H190N32O33
RDCHMFPSTY
ANL
2536.96
9.76
3
2
12
+1
0.83
-0.096
127.39
Mammalian: 4.4 hour Yeast: >20 hour E.coli: >10 hour
5500
2.17
5
Residue Composition
number
4
A
0
R
4
N
0
D
0
C
2
E
1
Q
1
G
0
H
1
I
4
L
3
K
0
M
0
F
0
P
0
S
0
T
1
W
0
Y
2
V
Amino Acid Distribution
A: 4 R: 0 N: 4 D: 0 C: 0 E: 2 Q: 1 G: 1 H: 0 I: 1 L: 4 K: 3 M: 0 F: 0 P: 0 S: 0 T: 0 W: 1 Y: 0 V: 2
Chemical Descriptors
23 reviewed residue count
C114H190N32O33 sequence-only estimate (linear, free termini)
2536.96 sequence-only estimate (linear, free termini)
9.76 sequence-only estimate (linear, free termini)
+1 sequence-only estimate (linear, free termini)
0.83 sequence-only estimate (linear, free termini)
-0.096 sequence-only estimate (linear, free termini)
Evidence Records 7 records
Evidence 1 Activity

Activity

IC50
Toxicity
4.85 µM
Cytotoxic
IC50 | 4.85 | µM | target cell: Human microvascular endothelial cells HMEC-1

Target

Human microvascular endothelial cells HMEC-1

Source & Reference

NA
DBAASP
Dermaseptin-PH: A Novel Peptide with Antimicrobial and Anticancer Activities from the Skin Secretion of the South American Orange-Legged Leaf Frog, Pithecopus (Phyllomedusa) hypochondrialis. | Molecules | 2017
Evidence 2 Activity

Activity

1% Hemolysis
Toxicity
16 µM
Hemolytic Cytotoxic
1% Hemolysis | 16 | µM | target cell: Horse erythrocytes

Target

Horse erythrocytes

Source & Reference

NA
DBAASP
Dermaseptin-PH: A Novel Peptide with Antimicrobial and Anticancer Activities from the Skin Secretion of the South American Orange-Legged Leaf Frog, Pithecopus (Phyllomedusa) hypochondrialis. | Molecules | 2017
Evidence 3 Activity

Activity

3% Hemolysis
Toxicity
64 µM
Hemolytic Cytotoxic
3% Hemolysis | 64 | µM | target cell: Horse erythrocytes

Target

Horse erythrocytes

Source & Reference

NA
DBAASP
Dermaseptin-PH: A Novel Peptide with Antimicrobial and Anticancer Activities from the Skin Secretion of the South American Orange-Legged Leaf Frog, Pithecopus (Phyllomedusa) hypochondrialis. | Molecules | 2017
Evidence 4 Activity

Activity

10% Hemolysis
Toxicity
128 µM
Hemolytic Cytotoxic
10% Hemolysis | 128 | µM | target cell: Horse erythrocytes

Target

Horse erythrocytes

Source & Reference

NA
DBAASP
Dermaseptin-PH: A Novel Peptide with Antimicrobial and Anticancer Activities from the Skin Secretion of the South American Orange-Legged Leaf Frog, Pithecopus (Phyllomedusa) hypochondrialis. | Molecules | 2017
Evidence 5 Activity

Activity

45% Hemolysis
Toxicity
256 µM
Hemolytic Cytotoxic
45% Hemolysis | 256 | µM | target cell: Horse erythrocytes

Target

Horse erythrocytes

Source & Reference

NA
DBAASP
Dermaseptin-PH: A Novel Peptide with Antimicrobial and Anticancer Activities from the Skin Secretion of the South American Orange-Legged Leaf Frog, Pithecopus (Phyllomedusa) hypochondrialis. | Molecules | 2017
Evidence 6 Activity

Activity

100% Hemolysis
Toxicity
512 µM
Hemolytic Cytotoxic
100% Hemolysis | 512 | µM | target cell: Horse erythrocytes

Target

Horse erythrocytes

Source & Reference

NA
DBAASP
Dermaseptin-PH: A Novel Peptide with Antimicrobial and Anticancer Activities from the Skin Secretion of the South American Orange-Legged Leaf Frog, Pithecopus (Phyllomedusa) hypochondrialis. | Molecules | 2017
Evidence 7 Activity

Activity

IC50
Toxicity
4.85 µM
Hemolytic Cytotoxic
Hemolytic_activity: Horse erythrocytes: 1% Hemolysis=16µM 3% Hemolysis=64µM 10% Hemolysis=128µM 45% Hemolysis=256µM 100% Hemolysis=512µM | Cytotoxicity: HMEC-1: IC50=4.85µM

Target

erythrocytes

Source & Reference

NA
DRAMP
Molecules. 2017 Oct 24 22(10):1805.