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Peptide record

TPDB10158

Antibacterial Anticancer Antifungal Hemolysis Toxicity standard
23 amino acids
Basic Information
3D PDB MODEL
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TPDB10158
Antibacterial Anticancer Antifungal Hemolysis Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia CancerPPD 2.0 Antifungipept CAFPdb PD_Hemolysis
standard
No
A 23-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
ALWKDILKNLLKAALNEINQIVQ
Physicochemical Analysis
C122H206N32O33
RCGHMFPSTY
L
2649.17
9.76
3
2
13
+1
2.62
0.217
161.30
Mammalian: 4.4 hour Yeast: >20 hour E.coli: >10 hour
5500
207.61
5
Residue Composition
number
3
A
0
R
3
N
1
D
0
C
1
E
2
Q
0
G
0
H
3
I
5
L
3
K
0
M
0
F
0
P
0
S
0
T
1
W
0
Y
1
V
Amino Acid Distribution
A: 3 R: 0 N: 3 D: 1 C: 0 E: 1 Q: 2 G: 0 H: 0 I: 3 L: 5 K: 3 M: 0 F: 0 P: 0 S: 0 T: 0 W: 1 Y: 0 V: 1
Chemical Descriptors
23
C122H206N32O33
2649.17
9.76
+1
2.62
0.217
Evidence Records 4 records
Evidence 1 Activity

Activity

IC50
Toxicity
8.76 µM
Cytotoxic
IC50 | 8.76 | µM | target cell: Human microvascular endothelial cells HMEC-1

Target

Human microvascular endothelial cells HMEC-1

Source & Reference

NA
DBAASP
Biological Activities of Cationicity-Enhanced and Hydrophobicity-Optimized Analogues of an Antimicrobial Peptide, Dermaseptin-PS3, from the Skin Secretion of Phyllomedusa sauvagii. | Toxins (Basel) | 2018
Evidence 2 Activity

Activity

50% Hemolysis
Toxicity
3.44 µM
Hemolytic Cytotoxic
50% Hemolysis | 3.44 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Biological Activities of Cationicity-Enhanced and Hydrophobicity-Optimized Analogues of an Antimicrobial Peptide, Dermaseptin-PS3, from the Skin Secretion of Phyllomedusa sauvagii. | Toxins (Basel) | 2018
Evidence 3 Activity

Activity

IC50
Toxicity
0.12 µM
Hemolytic Cytotoxic
Hemolytic_activity: [Ref.30087268] 20% hemolysis at 0 µM , 70% hemolysis at 1 µM , 95% hemolysis at 2 µM against horse red blood cells | Cytotoxicity: [Ref.30087268] IC50 = 0.12 µM for H157. ##IC50 = 1.85 µM for PC3. ##IC50 = 8.76 µM for HMEC-1

Target

erythrocytes

Source & Reference

NA
DRAMP
Toxins (Basel). 2018 Aug 7 10(8). pii: E320. doi: 10.3390/toxins10080320.
Evidence 4 Hemolysis

Source & Reference

PD_Hemolysis
PD_Hemolysis