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Peptide record

TPDB10157

Antibacterial Toxicity standard
23 amino acids
Basic Information
3D PDB MODEL
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TPDB10157
Antibacterial Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia
standard
No
A 23-aa standard natural multi-activity (Antibacterial and Toxicity) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
AIGSILGRLAKGLPTLKSWIKNR
Physicochemical Analysis
C114H198N34O28
DCEQHMFYV
L
2493.04
12.43
5
0
10
+5
0.53
0.091
127.39
Mammalian: 4.4 hour Yeast: >20 hour E.coli: >10 hour
5500
220.61
4
Residue Composition
number
2
A
2
R
1
N
0
D
0
C
0
E
0
Q
3
G
0
H
3
I
4
L
3
K
0
M
0
F
1
P
2
S
1
T
1
W
0
Y
0
V
Amino Acid Distribution
A: 2 R: 2 N: 1 D: 0 C: 0 E: 0 Q: 0 G: 3 H: 0 I: 3 L: 4 K: 3 M: 0 F: 0 P: 1 S: 2 T: 1 W: 1 Y: 0 V: 0
Chemical Descriptors
23
C114H198N34O28
2493.04
12.43
+5
0.53
0.091
Evidence Records 2 records
Evidence 1 Activity

Activity

10% Hemolysis
Toxicity
100 µM
Hemolytic Cytotoxic
10% Hemolysis | 100 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Design of an ?-helical antimicrobial peptide with improved cell-selective and potent anti-biofilm activity. | Sci Rep | 2016
Evidence 2 Activity

Activity

% Hemolysis
Toxicity
2 %
Hemolytic Cytotoxic
Hemolytic_activity: [Ref.27271216] 2% hemolysis at 20 [Ref.27271216] 2% hemolysis at 20 µM , 5% hemolysis at 40 µM , 10% hemolysis at 60 µM , 20% hemolysis at 80 µM , 30% hemolysis at 100 µM against human red blood cells | Cytotoxicity: [Ref.27271216] In L929 cells, the cell viability is 100%, 99%, 92%, 64% and 21.1% at peptide concentrations of 3.12, 6.25, 12.5, 25 and 50 µM.

Target

erythrocytes

Source & Reference

NA
DRAMP
Sci Rep. 2016 Jun 8 6:27394. doi: 10.1038/srep27394.