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Peptide record

TPDB10153

Antibacterial Toxicity standard
23 amino acids
Basic Information
3D PDB MODEL
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TPDB10153
Antibacterial Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 Peptipedia
standard
No
A 23-aa standard natural multi-activity (Antibacterial and Toxicity) peptide sequence curated from AntiBP3 and Peptipedia, with an available 3D structural model.
Sequence
VCRTGRSRWRDVCRNFMRRYQSR
Physicochemical Analysis
C123H202N50O32S3
AEHILKP
R
2989.45
12.18
8
1
6
+7
4.63
-1.448
25.22
Mammalian: 100 hour Yeast: >20 hour E.coli: >10 hour
7115
238.00
8
Residue Composition
number
0
A
8
R
1
N
1
D
2
C
0
E
1
Q
1
G
0
H
0
I
0
L
0
K
1
M
1
F
0
P
2
S
1
T
1
W
1
Y
2
V
Amino Acid Distribution
A: 0 R: 8 N: 1 D: 1 C: 2 E: 0 Q: 1 G: 1 H: 0 I: 0 L: 0 K: 0 M: 1 F: 1 P: 0 S: 2 T: 1 W: 1 Y: 1 V: 2
Chemical Descriptors
23
C123H202N50O32S3
2989.45
12.18
+7
4.63
-1.448
Evidence Records 2 records
Evidence 1 Activity

Activity

50% Hemolysis
Toxicity
>300 µM
Hemolytic Cytotoxic
50% Hemolysis | >300 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Comparative analysis of internalisation, haemolytic, cytotoxic and antibacterial effect of membrane-active cationic peptides: aspects of experimental setup. | Amino Acids | 2017
Evidence 2 Activity

Activity

IC50
Toxicity
80.1±18.5 µM
Cytotoxic
IC50 | 80.1±18.5 | µM | target cell: Human PBMC

Target

Human PBMC

Source & Reference

NA
DBAASP
Comparative analysis of internalisation, haemolytic, cytotoxic and antibacterial effect of membrane-active cationic peptides: aspects of experimental setup. | Amino Acids | 2017