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Peptide record

TPDB10149

Antibacterial Antifungal Toxicity standard
23 amino acids
Basic Information
3D PDB MODEL
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TPDB10149
Antibacterial Antifungal Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 Peptipedia Antifungipept CAFPdb dbAMP
standard
No
A 23-aa standard-residue multi-activity (Antibacterial, Antifungal, and Toxicity) peptide sequence curated from AntiBP3, Peptipedia, Antifungipept, and other sources, with an available 3D structural model.
Sequence
DHNNEIVKIQSLLRANKARDDYK
Physicochemical Analysis

Sequence-only estimates for a linear peptide with free termini, not experimentally measured molecular properties. Mass and formula exclude cyclization and disulfide formation. The optical estimates assume paired cysteines, 280 nm, 1 g/L and a 1 cm path. The N-end rule estimate is not a measured plasma half-life.

C117H194N38O38
CGMFPTW
NDK
2741.06
9.58
6
4
8
+1
3.73
-1.287
89.13
Mammalian: 1.1 hour Yeast: 3 min E.coli: >10 hour
1490
0.54
6
Residue Composition
number
2
A
2
R
3
N
3
D
0
C
1
E
1
Q
0
G
1
H
2
I
2
L
3
K
0
M
0
F
0
P
1
S
0
T
0
W
1
Y
1
V
Amino Acid Distribution
A: 2 R: 2 N: 3 D: 3 C: 0 E: 1 Q: 1 G: 0 H: 1 I: 2 L: 2 K: 3 M: 0 F: 0 P: 0 S: 1 T: 0 W: 0 Y: 1 V: 1
Chemical Descriptors
23 reviewed residue count
C117H194N38O38 sequence-only estimate (linear, free termini)
2741.06 sequence-only estimate (linear, free termini)
9.58 sequence-only estimate (linear, free termini)
+1 sequence-only estimate (linear, free termini)
3.73 sequence-only estimate (linear, free termini)
-1.287 sequence-only estimate (linear, free termini)
Evidence Records 1 records
Evidence 1 Activity

Activity

2.5% Hemolysis
Toxicity
100-200 µg/mL
Hemolytic Cytotoxic
2.5% Hemolysis | 100-200 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
IQ-motif peptides as novel anti-microbial agents. | Biochimie | 2013