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Peptide record

TPDB10132

Antibacterial Toxicity standard
23 amino acids
Basic Information
3D PDB MODEL
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TPDB10132
Antibacterial Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 Peptipedia
standard
No
A 23-aa standard natural multi-activity (Antibacterial and Toxicity) peptide sequence curated from AntiBP3 and Peptipedia, with an available 3D structural model.
Sequence
YYHFWHRGVTKRSLSPHRPRHSR
Physicochemical Analysis
C134H198N48O30
ANDCEQIM
R
2961.35
12.24
10
0
6
+6
4.97
-1.678
29.57
Mammalian: 2.8 hour Yeast: 10 min E.coli: 2 min
8480
286.36
6
Residue Composition
number
0
A
5
R
0
N
0
D
0
C
0
E
0
Q
1
G
4
H
0
I
1
L
1
K
0
M
1
F
2
P
3
S
1
T
1
W
2
Y
1
V
Amino Acid Distribution
A: 0 R: 5 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 1 H: 4 I: 0 L: 1 K: 1 M: 0 F: 1 P: 2 S: 3 T: 1 W: 1 Y: 2 V: 1
Chemical Descriptors
23
C134H198N48O30
2961.35
12.24
+6
4.97
-1.678
Evidence Records 10 records
Evidence 1 Activity

Activity

MIC
Antibacterial
4 µM

Target

Escherichia coli

Source & Reference

NA

Other

Active against E. coli (MIC 4 uM), P. aeruginosa (MIC 4 uM) S. enterica (MIC 4 uM) K. pneumoniae (MIC 2 uM) S. aureus (M
Evidence 2 Activity

Activity

MIC
Antibacterial
4 µM

Target

Pseudomonas aeruginosa

Source & Reference

NA

Other

Active against E. coli (MIC 4 uM), P. aeruginosa (MIC 4 uM) S. enterica (MIC 4 uM) K. pneumoniae (MIC 2 uM) S. aureus (MIC 4 uM) B. subtilis (MIC
Evidence 3 Activity

Activity

MIC
Antibacterial
4 µM

Target

S. enterica

Source & Reference

NA

Other

Active against E. coli (MIC 4 uM), P. aeruginosa (MIC 4 uM) S. enterica (MIC 4 uM) K. pneumoniae (MIC 2 uM) S. aureus (MIC 4 uM) B. subtilis (MIC 4 uM) S. pyogenes (MIC
Evidence 4 Activity

Activity

MIC
Antibacterial
2 µM

Target

Klebsiella pneumoniae

Source & Reference

NA

Other

Active against E. coli (MIC 4 uM), P. aeruginosa (MIC 4 uM) S. enterica (MIC 4 uM) K. pneumoniae (MIC 2 uM) S. aureus (MIC 4 uM) B. subtilis (MIC 4 uM) S. pyogenes (MIC 6 uM) and E. faecalis (M
Evidence 5 Activity

Activity

MIC
Antibacterial
4 µM

Target

Staphylococcus aureus

Source & Reference

NA

Other

i (MIC 4 uM), P. aeruginosa (MIC 4 uM) S. enterica (MIC 4 uM) K. pneumoniae (MIC 2 uM) S. aureus (MIC 4 uM) B. subtilis (MIC 4 uM) S. pyogenes (MIC 6 uM) and E. faecalis (MIC 4 uM).
Evidence 6 Activity

Activity

MIC
Antibacterial
4 µM

Target

B. subtilis

Source & Reference

NA

Other

inosa (MIC 4 uM) S. enterica (MIC 4 uM) K. pneumoniae (MIC 2 uM) S. aureus (MIC 4 uM) B. subtilis (MIC 4 uM) S. pyogenes (MIC 6 uM) and E. faecalis (MIC 4 uM).
Evidence 7 Activity

Activity

MIC
Antibacterial
6 µM

Target

Streptococcus pyogenes

Source & Reference

NA

Other

erica (MIC 4 uM) K. pneumoniae (MIC 2 uM) S. aureus (MIC 4 uM) B. subtilis (MIC 4 uM) S. pyogenes (MIC 6 uM) and E. faecalis (MIC 4 uM).
Evidence 8 Activity

Activity

MIC
Antibacterial
4 µM

Target

Enterococcus faecalis

Source & Reference

NA

Other

iae (MIC 2 uM) S. aureus (MIC 4 uM) B. subtilis (MIC 4 uM) S. pyogenes (MIC 6 uM) and E. faecalis (MIC 4 uM).
Evidence 9 Activity

Activity

<5% Hemolysis
Toxicity
150 µM
Hemolytic Cytotoxic
<5% Hemolysis | 150 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Cell-Selective Pore Forming Antimicrobial Peptides of the Prodomain of Human Furin: A Conserved Aromatic/Cationic Sequence Mapping, Membrane Disruption, and Atomic-Resolution Structure and Dynamics. | ACS Omega | 2018
Evidence 10 Activity

Activity

5% Killing
Toxicity
100 µM
Cytotoxic
5% Killing | 100 | µM | target cell: Mouse fibroblasts NIH 3T3

Target

Mouse fibroblasts NIH 3T3

Source & Reference

NA
DBAASP
Cell-Selective Pore Forming Antimicrobial Peptides of the Prodomain of Human Furin: A Conserved Aromatic/Cationic Sequence Mapping, Membrane Disruption, and Atomic-Resolution Structure and Dynamics. | ACS Omega | 2018