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Peptide record

TPDB10129

Antibacterial Antifungal Toxicity standard
23 amino acids
Basic Information
3D PDB MODEL
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TPDB10129
Antibacterial Antifungal Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 Peptipedia Antifungipept CAFPdb dbAMP
standard
No
A 23-aa standard-residue multi-activity (Antibacterial, Antifungal, and Toxicity) peptide sequence curated from AntiBP3, Peptipedia, Antifungipept, and other sources, with an available 3D structural model.
Sequence
SRWPSPGRPRPFPGRPKPIFRPR
Physicochemical Analysis

Sequence-only estimates for a linear peptide with free termini, not experimentally measured molecular properties. Mass and formula exclude cyclization and disulfide formation. The optical estimates assume paired cysteines, 280 nm, 1 g/L and a 1 cm path. The N-end rule estimate is not a measured plasma half-life.

C127H197N43O26
ANDCEQHLMTYV
P
2742.23
13.10
7
0
4
+7
3.77
-1.604
16.96
Mammalian: 1.9 hour Yeast: >20 hour E.coli: >10 hour
5500
2.01
2
Residue Composition
number
0
A
6
R
0
N
0
D
0
C
0
E
0
Q
2
G
0
H
1
I
0
L
1
K
0
M
2
F
8
P
2
S
0
T
1
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 6 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 2 H: 0 I: 1 L: 0 K: 1 M: 0 F: 2 P: 8 S: 2 T: 0 W: 1 Y: 0 V: 0
Chemical Descriptors
23 reviewed residue count
C127H197N43O26 sequence-only estimate (linear, free termini)
2742.23 sequence-only estimate (linear, free termini)
13.10 sequence-only estimate (linear, free termini)
+7 sequence-only estimate (linear, free termini)
3.77 sequence-only estimate (linear, free termini)
-1.604 sequence-only estimate (linear, free termini)
Evidence Records 1 records
Evidence 1 Activity

Activity

Toxicity
Hemolytic Cytotoxic
- | NA | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Structure-activity relationships of the antimicrobial peptide arasin 1 - and mode of action studies of the N-terminal, proline-rich region. | PLoS One | 2013